syrosingopine-2753 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the syrosingopine-2753 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD12 ankyrin repeat domain 12
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMC8 armadillo repeat containing 8
ASIC1 acid sensing (proton gated) ion channel 1
ATF3 activating transcription factor 3
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BEX4 brain expressed, X-linked 4
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLGN calmegin
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DTNA dystrobrevin, alpha
EFNB3 ephrin-B3
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
EPOR erythropoietin receptor
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GMPR guanosine monophosphate reductase
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ICAM1 intercellular adhesion molecule 1
IL21R interleukin 21 receptor
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
KIF5C kinesin family member 5C
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LOC157562 uncharacterized LOC157562
LPIN1 lipin 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP4 latent transforming growth factor beta binding protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MED6 mediator complex subunit 6
MFAP3L microfibrillar-associated protein 3-like
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MST1 macrophage stimulating 1
MTSS1 metastasis suppressor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NDE1 nudE neurodevelopment protein 1
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE9A phosphodiesterase 9A
PER1 period circadian clock 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRSS8 protease, serine, 8
QPCTL glutaminyl-peptide cyclotransferase-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE4 ribonuclease, RNase A family, 4
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIRT4 sirtuin 4
SLC35E2 solute carrier family 35, member E2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRCAP Snf2-related CREBBP activator protein
SSBP1 single-stranded DNA binding protein 1, mitochondrial
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNGR3 synaptogyrin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX19 T-box 19
THAP3 THAP domain containing, apoptosis associated protein 3
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TXNIP thioredoxin interacting protein
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WDR59 WD repeat domain 59
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF277 zinc finger protein 277
ZNF821 zinc finger protein 821
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
AGR2 anterior gradient 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
B9D2 B9 protein domain 2
BCAS1 breast carcinoma amplified sequence 1
BFSP1 beaded filament structural protein 1, filensin
C19ORF40 chromosome 19 open reading frame 40
C2ORF27A chromosome 2 open reading frame 27A
C2ORF54 chromosome 2 open reading frame 54
C4ORF19 chromosome 4 open reading frame 19
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CCNE2 cyclin E2
CENPO centromere protein O
CFAP44 cilia and flagella associated protein 44
CNGB3 cyclic nucleotide gated channel beta 3
CNR2 cannabinoid receptor 2 (macrophage)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAF1 DEAF1 transcription factor
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
FAM189A2 family with sequence similarity 189, member A2
FASTKD5 FAST kinase domains 5
FRS2 fibroblast growth factor receptor substrate 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HDAC4 histone deacetylase 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H4F histone cluster 1, H4f
HOXC13 homeobox C13
HPS6 Hermansky-Pudlak syndrome 6
IFT22 intraflagellar transport 22
IL17RB interleukin 17 receptor B
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IQCG IQ motif containing G
JMJD4 jumonji domain containing 4
KIAA0125 KIAA0125
KITLG KIT ligand
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MEPCE methylphosphate capping enzyme
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPHOSPH8 M-phase phosphoprotein 8
MTERF4 mitochondrial transcription termination factor 4
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NPY5R neuropeptide Y receptor Y5
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PC pyruvate carboxylase
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
POLH polymerase (DNA directed), eta
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RIBC2 RIB43A domain with coiled-coils 2
RIC8B RIC8 guanine nucleotide exchange factor B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPAP1 RNA polymerase II associated protein 1
SAYSD1 SAYSVFN motif domain containing 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SIDT1 SID1 transmembrane family, member 1
SLC12A9 solute carrier family 12, member 9
SLIT2 slit homolog 2 (Drosophila)
SPINK5 serine peptidase inhibitor, Kazal type 5
STARD13 StAR-related lipid transfer (START) domain containing 13
TET3 tet methylcytosine dioxygenase 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM209 transmembrane protein 209
TMPRSS3 transmembrane protease, serine 3
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOE1 target of EGR1, member 1 (nuclear)
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TWISTNB TWIST neighbor
UBIAD1 UbiA prenyltransferase domain containing 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USP36 ubiquitin specific peptidase 36
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED8 zinc finger, BED-type containing 8
ZBTB38 zinc finger and BTB domain containing 38
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF480 zinc finger protein 480
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNHIT2 zinc finger, HIT-type containing 2
ZXDC ZXD family zinc finger C