t-tubule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. (Gene Ontology, GO_0030315)
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Genes

221 proteins co-occuring with the t-tubule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.64009
QDPR quinoid dihydropteridine reductase 2.183
RYR1 ryanodine receptor 1 (skeletal) 2.07069
JPH2 junctophilin 2 1.82186
CASQ2 calsequestrin 2 (cardiac muscle) 1.78583
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 1.7695
TRDN triadin 1.73247
CAV3 caveolin 3 1.70137
BIN1 bridging integrator 1 1.40746
JPH1 junctophilin 1 1.40075
SYPL2 synaptophysin-like 2 1.28516
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.27133
DNAH8 dynein, axonemal, heavy chain 8 1.23348
MTM1 myotubularin 1 1.05741
RYR3 ryanodine receptor 3 1.0413
DYSF dysferlin 1.0253
DMD dystrophin 1.01833
INS insulin 1.00153
AMPH amphiphysin 0.858473
ANK2 ankyrin 2, neuronal 0.858473
AHNAK2 AHNAK nucleoprotein 2 0.85388
KAAG1 kidney associated antigen 1 0.843778
SLMAP sarcolemma associated protein 0.841482
AKAP7 A kinase (PRKA) anchor protein 7 0.839646
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.804772
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.799728
RYR2 ryanodine receptor 2 (cardiac) 0.795604
DRD4 dopamine receptor D4 0.769995
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.751357
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.741867
TAAR6 trace amine associated receptor 6 0.728389
MGAM maltase-glucoamylase 0.719906
GLE1 GLE1 RNA export mediator 0.715458
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.711908
AHNAK AHNAK nucleoprotein 0.709693
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.706156
IRF6 interferon regulatory factor 6 0.70439
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.690764
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.690764
ZNF189 zinc finger protein 189 0.672026
FKBP1A FK506 binding protein 1A, 12kDa 0.664232
TGFA transforming growth factor, alpha 0.660345
VAX1 ventral anterior homeobox 1 0.656464
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.64958
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.640573
ASPH aspartate beta-hydroxylase 0.638861
TBX10 T-box 10 0.634159
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.632451
FER1L5 fer-1-like family member 5 0.630745
CAPN3 calpain 3, (p94) 0.626057
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.617982
SLITRK1 SLIT and NTRK-like family, member 1 0.601909
DUSP27 dual specificity phosphatase 27 (putative) 0.598538
PLN phospholamban 0.583849
GRIK3 glutamate receptor, ionotropic, kainate 3 0.574662
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 0.570496
MYOF myoferlin 0.555559
SLC22A24 solute carrier family 22, member 24 0.555559
MTMR12 myotubularin related protein 12 0.548122
LRRC10 leucine rich repeat containing 10 0.541117
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.532898
FHIT fragile histidine triad 0.525522
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.521841
SCN1B sodium channel, voltage gated, type I beta subunit 0.515716
ACHE acetylcholinesterase (Yt blood group) 0.512862
ALX3 ALX homeobox 3 0.512047
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.51164
ANK1 ankyrin 1, erythrocytic 0.509197
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.503506
SETD7 SET domain containing (lysine methyltransferase) 7 0.500664
GJA1 gap junction protein, alpha 1, 43kDa 0.492966
ZIC2 Zic family member 2 0.485693
ATP11A ATPase, class VI, type 11A 0.483676
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.476429
ANXA6 annexin A6 0.47442
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.472813
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.471208
FTO fat mass and obesity associated 0.470005
PANX1 pannexin 1 0.457606
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.457208
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.45641
ADCY2 adenylate cyclase 2 (brain) 0.452029
F2 coagulation factor II (thrombin) 0.449245
TFDP3 transcription factor Dp family, member 3 0.447656
TCAP titin-cap 0.442104
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.43617
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.434591
CD58 CD58 molecule 0.433801
MKX mohawk homeobox 0.432618
COMT catechol-O-methyltransferase 0.431435
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.429465
FXYD1 FXYD domain containing ion transport regulator 1 0.427891
RAB6B RAB6B, member RAS oncogene family 0.413773
SEPN1 selenoprotein N, 1 0.408309
MTMR14 myotubularin related protein 14 0.406361
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.403637
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.401693
TTN titin 0.400916
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.398587
STAC3 SH3 and cysteine rich domain 3 0.397035
STBD1 starch binding domain 1 0.396648
GPR88 G protein-coupled receptor 88 0.395098
MBNL1 muscleblind-like splicing regulator 1 0.393549
ART3 ADP-ribosyltransferase 3 0.385051
MSX1 msh homeobox 1 0.378891
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.378122
CBLN4 cerebellin 4 precursor 0.378122
CNTN3 contactin 3 (plasmacytoma associated) 0.377738
ATF7IP activating transcription factor 7 interacting protein 0.374283
ARHGAP29 Rho GTPase activating protein 29 0.372749
SRL sarcalumenin 0.366241
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 0.364331
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.363567
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.362422
VCL vinculin 0.355563
PVALB parvalbumin 0.352142
NT5E 5'-nucleotidase, ecto (CD73) 0.349105
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.345314
DCDC2 doublecortin domain containing 2 0.340773
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.340773
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.336619
GSTP1 glutathione S-transferase pi 1 0.333979
MMD monocyte to macrophage differentiation-associated 0.330213
DTNA dystrobrevin, alpha 0.330213
IRX4 iroquois homeobox 4 0.322325
LHX8 LIM homeobox 8 0.322325
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.320826
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.319328
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.313344
TBX4 T-box 4 0.309986
BHMT betaine--homocysteine S-methyltransferase 0.30924
DCPS decapping enzyme, scavenger 0.30626
FTL ferritin, light polypeptide 0.304771
FTH1 ferritin, heavy polypeptide 1 0.302912
GSTM4 glutathione S-transferase mu 4 0.302168
C1ORF167 chromosome 1 open reading frame 167 0.300682
MURC muscle-related coiled-coil protein 0.299197
JSRP1 junctional sarcoplasmic reticulum protein 1 0.298826
CD320 CD320 molecule 0.297713
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.292897
GNS glucosamine (N-acetyl)-6-sulfatase 0.290308
CBLN2 cerebellin 2 precursor 0.289938
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 0.285876
FGF11 fibroblast growth factor 11 0.284032
FRMD7 FERM domain containing 7 0.283295
CELF1 CUGBP, Elav-like family member 1 0.282189
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.281085
AVPR2 arginine vasopressin receptor 2 0.278509
TGFB3 transforming growth factor, beta 3 0.274468
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.273
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.271167
DOC2B double C2-like domains, beta 0.268603
FGF17 fibroblast growth factor 17 0.265677
SSPN sarcospan 0.264946
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.264215
ZDHHC8 zinc finger, DHHC-type containing 8 0.259109
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.256925
CD276 CD276 molecule 0.256197
VAMP5 vesicle-associated membrane protein 5 0.253291
EDNRA endothelin receptor type A 0.247854
ADRB2 adrenoceptor beta 2, surface 0.245685
INTU inturned planar cell polarity protein 0.242797
BAG2 BCL2-associated athanogene 2 0.241716
FGF13 fibroblast growth factor 13 0.239916
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.238837
FGF12 fibroblast growth factor 12 0.234174
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.233817
ADRB3 adrenoceptor beta 3 0.231672
SLN sarcolipin 0.230601
CLCN1 chloride channel, voltage-sensitive 1 0.225267
WDR92 WD repeat domain 92 0.222083
SDF4 stromal cell derived factor 4 0.22173
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.219265
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.218914
BSN bassoon presynaptic cytomatrix protein 0.21681
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 0.215412
SACS sacsin molecular chaperone 0.21124
ZIC3 Zic family member 3 0.209513
SPRY4 sprouty homolog 4 (Drosophila) 0.208825
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.207451
GPANK1 G patch domain and ankyrin repeats 1 0.203361
ANXA7 annexin A7 0.202684
FOXE1 forkhead box E1 0.202009
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.202009
TCN2 transcobalamin II 0.196999
DNM2 dynamin 2 0.196339
AGTRAP angiotensin II receptor-associated protein 0.196339
WRAP73 WD repeat containing, antisense to TP73 0.195353
KIF3C kinesin family member 3C 0.195025
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.194045
SCN5A sodium channel, voltage gated, type V alpha subunit 0.190495
ETV5 ets variant 5 0.190175
STIM1 stromal interaction molecule 1 0.190175
SLC16A4 solute carrier family 16, member 4 0.189539
PRKD1 protein kinase D1 0.18796
CALCA calcitonin-related polypeptide alpha 0.187646
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.187646
AKAP5 A kinase (PRKA) anchor protein 5 0.18516
CAV1 caveolin 1, caveolae protein, 22kDa 0.184853
FN1 fibronectin 1 0.184547
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.181524
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.180634
NPAS2 neuronal PAS domain protein 2 0.179752
PDCD1LG2 programmed cell death 1 ligand 2 0.177154
MIR22 microRNA 22 0.176587
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.175466
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.170371
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.169604
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.168847
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.167125
EPHA2 EPH receptor A2 0.164542
PREP prolyl endopeptidase 0.164315
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.163641
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.159658
BVES blood vessel epicardial substance 0.158315
ERBB4 erb-b2 receptor tyrosine kinase 4 0.15776
GLRA2 glycine receptor, alpha 2 0.157578
ALPP alkaline phosphatase, placental 0.157397
SDPR serum deprivation response 0.156863
ALB albumin 0.156513
PARP6 poly (ADP-ribose) polymerase family, member 6 0.156513