tRNA Aminoacylation Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. (Gene Ontology, GO_0043039)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-379724
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Genes

42 proteins participating in the tRNA Aminoacylation pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AARS1 alanyl-tRNA synthetase 1
AARS2 alanyl-tRNA synthetase 2, mitochondrial
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
CARS1 cysteinyl-tRNA synthetase 1
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
DARS1 aspartyl-tRNA synthetase 1
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EPRS1 glutamyl-prolyl-tRNA synthetase 1
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FARSB phenylalanyl-tRNA synthetase, beta subunit
GARS1 glycyl-tRNA synthetase 1
HARS1 histidyl-tRNA synthetase 1
HARS2 histidyl-tRNA synthetase 2, mitochondrial
IARS1 isoleucyl-tRNA synthetase 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KARS1 lysyl-tRNA synthetase 1
LARS1 leucyl-tRNA synthetase 1
LARS2 leucyl-tRNA synthetase 2, mitochondrial
MARS1 methionyl-tRNA synthetase 1
MARS2 methionyl-tRNA synthetase 2, mitochondrial
NARS1 asparaginyl-tRNA synthetase 1
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PPA1 pyrophosphatase (inorganic) 1
PPA2 pyrophosphatase (inorganic) 2
QARS1 glutaminyl-tRNA synthetase 1
RARS1 arginyl-tRNA synthetase 1
RARS2 arginyl-tRNA synthetase 2, mitochondrial
SARS1 seryl-tRNA synthetase 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
TARS1 threonyl-tRNA synthetase 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
VARS1 valyl-tRNA synthetase 1
VARS2 valyl-tRNA synthetase 2, mitochondrial
WARS1 tryptophanyl-tRNA synthetase 1
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
YARS1 tyrosyl-tRNA synthetase 1
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial