tRNA modification Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. (Gene Ontology, GO_0006400)
External Link http://amigo.geneontology.org/amigo/term/GO:0006400
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Genes

72 genes participating in the tRNA modification biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AARS1 alanyl-tRNA synthetase 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH8 alkB, alkylation repair homolog 8 (E. coli)
ANKRD16 ankyrin repeat domain 16
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCDIN3D BCDIN3 domain containing
C9ORF64 chromosome 9 open reading frame 64
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CTU1 cytosolic thiouridylase subunit 1
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe)
DTWD1 DTW domain containing 1
DTWD2 DTW domain containing 2
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
DUS2 dihydrouridine synthase 2
DUS3L dihydrouridine synthase 3-like (S. cerevisiae)
DUS4L dihydrouridine synthase 4-like (S. cerevisiae)
ELP5 elongator acetyltransferase complex subunit 5
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GON7 GON7 subunit of KEOPS complex
GTDC1 glycosyltransferase-like domain containing 1
GTPBP3 GTP binding protein 3 (mitochondrial)
LCMT2 leucine carboxyl methyltransferase 2
METTL1 methyltransferase like 1
METTL2A methyltransferase like 2A
METTL2B methyltransferase like 2B
METTL6 methyltransferase like 6
METTL8 methyltransferase like 8
MOCS3 molybdenum cofactor synthesis 3
MTO1 mitochondrial tRNA translation optimization 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NSUN6 NOP2/Sun domain family, member 6
OSGEP O-sialoglycoprotein endopeptidase
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PUS1 pseudouridylate synthase 1
PUS10 pseudouridylate synthase 10
PUS3 pseudouridylate synthase 3
PUS7 pseudouridylate synthase 7 (putative)
PUSL1 pseudouridylate synthase-like 1
QTRT1 queuine tRNA-ribosyltransferase 1
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2
SARS1 seryl-tRNA synthetase 1
SSB Sjogren syndrome antigen B (autoantigen La)
TARBP1 TAR (HIV-1) RNA binding protein 1
THADA thyroid adenoma associated
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
THUMPD1 THUMP domain containing 1
THUMPD2 THUMP domain containing 2
THUMPD3 THUMP domain containing 3
TP53RK TP53 regulating kinase
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIT1 tRNA isopentenyltransferase 1
TRMO tRNA methyltransferase O
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae)
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRMT61A tRNA methyltransferase 61A
TRMT61B tRNA methyltransferase 61B
TRMT9B tRNA methyltransferase 9B (putative)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRUB1 TruB pseudouridine (psi) synthase family member 1
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
TYW5 tRNA-yW synthesizing protein 5
URM1 ubiquitin related modifier 1
WDR4 WD repeat domain 4
WDR6 WD repeat domain 6
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing