tacrine-1278 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tacrine-1278 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ADAM10 ADAM metallopeptidase domain 10
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APAF1 apoptotic peptidase activating factor 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP13A3 ATPase type 13A3
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTD biotinidase
C6ORF62 chromosome 6 open reading frame 62
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD46 CD46 molecule, complement regulatory protein
CDV3 CDV3 homolog (mouse)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSZ cathepsin Z
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBT dihydrolipoamide branched chain transacylase E2
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DLG1 discs, large homolog 1 (Drosophila)
DTNA dystrobrevin, alpha
ELL2 elongation factor, RNA polymerase II, 2
ENDOD1 endonuclease domain containing 1
ERLIN1 ER lipid raft associated 1
F12 coagulation factor XII (Hageman factor)
FBXW11 F-box and WD repeat domain containing 11
FNTB farnesyltransferase, CAAX box, beta
FST follistatin
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HCRP1 hepatocellular carcinoma-related HCRP1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIPK3 homeodomain interacting protein kinase 3
HSPA4 heat shock 70kDa protein 4
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDE insulin-degrading enzyme
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KCTD20 potassium channel tetramerization domain containing 20
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK14 mitogen-activated protein kinase 14
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MVD mevalonate (diphospho) decarboxylase
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFYA nuclear transcription factor Y, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
NXT2 nuclear transport factor 2-like export factor 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PCM1 pericentriolar material 1
PHACTR1 phosphatase and actin regulator 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLSCR3 phospholipid scramblase 3
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSEN1 presenilin 1
PTAFR platelet-activating factor receptor
PTBP1 polypyrimidine tract binding protein 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRA protein tyrosine phosphatase, receptor type, A
RAB6A RAB6A, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RALB v-ral simian leukemia viral oncogene homolog B
RASA3 RAS p21 protein activator 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RFXAP regulatory factor X-associated protein
RNF6 ring finger protein (C3H2C3 type) 6
SC5D sterol-C5-desaturase
SCARB2 scavenger receptor class B, member 2
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAP23 synaptosomal-associated protein, 23kDa
SNRPN small nuclear ribonucleoprotein polypeptide N
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STX16 syntaxin 16
TJAP1 tight junction associated protein 1 (peripheral)
TMEM259 transmembrane protein 259
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPMT thiopurine S-methyltransferase
TRAF3IP3 TRAF3 interacting protein 3
TRAIP TRAF interacting protein
TWISTNB TWIST neighbor
UTRN utrophin
ZBTB40 zinc finger and BTB domain containing 40
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD5 ATPase family, AAA domain containing 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C19ORF40 chromosome 19 open reading frame 40
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
C5AR1 complement component 5a receptor 1
C6ORF47 chromosome 6 open reading frame 47
CALCOCO1 calcium binding and coiled-coil domain 1
CHMP7 charged multivesicular body protein 7
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
COPS7B COP9 signalosome subunit 7B
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSAD cysteine sulfinic acid decarboxylase
CTDNEP1 CTD nuclear envelope phosphatase 1
DBR1 debranching RNA lariats 1
DEPDC1 DEP domain containing 1
DGKZ diacylglycerol kinase, zeta
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DPY19L2P2 DPY19L2 pseudogene 2
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM134C family with sequence similarity 134, member C
FAM53B family with sequence similarity 53, member B
FBXL15 F-box and leucine-rich repeat protein 15
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHOD1 formin homology 2 domain containing 1
FMNL1 formin-like 1
GGTLC1 gamma-glutamyltransferase light chain 1
GRAMD1B GRAM domain containing 1B
GTPBP6 GTP binding protein 6 (putative)
HHLA3 HERV-H LTR-associating 3
HPS6 Hermansky-Pudlak syndrome 6
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITPKB inositol-trisphosphate 3-kinase B
KAT2A K(lysine) acetyltransferase 2A
KIF13B kinesin family member 13B
KIF3B kinesin family member 3B
KPTN kaptin (actin binding protein)
LMBR1L limb development membrane protein 1-like
LZTR1 leucine-zipper-like transcription regulator 1
MAGOHB mago-nashi homolog B (Drosophila)
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1S microtubule-associated protein 1S
MBD5 methyl-CpG binding domain protein 5
MBTD1 mbt domain containing 1
MCRS1 microspherule protein 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MED15 mediator complex subunit 15
MED22 mediator complex subunit 22
MGC12488
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYBBP1A MYB binding protein (P160) 1a
MYO19 myosin XIX
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NRBP1 nuclear receptor binding protein 1
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P3H1 prolyl 3-hydroxylase 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PELP1 proline, glutamate and leucine rich protein 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RARS arginyl-tRNA synthetase
RPA4 replication protein A4, 30kDa
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSAD1 radical S-adenosyl methionine domain containing 1
SEC31B SEC31 homolog B (S. cerevisiae)
SFMBT1 Scm-like with four mbt domains 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIPA1 signal-induced proliferation-associated 1
SIRT2 sirtuin 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STIM1 stromal interaction molecule 1
STK16 serine/threonine kinase 16
THEM6 thioesterase superfamily member 6
TMEM127 transmembrane protein 127
TMEM159 transmembrane protein 159
TPCN1 two pore segment channel 1
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM26 tripartite motif containing 26
TSSC4 tumor suppressing subtransferable candidate 4
UBQLN4 ubiquilin 4
XPA xeroderma pigmentosum, complementation group A
ZBTB48 zinc finger and BTB domain containing 48
ZFP30 ZFP30 zinc finger protein
ZNF16 zinc finger protein 16
ZNF250 zinc finger protein 250
ZNF629 zinc finger protein 629
ZNF787 zinc finger protein 787
ZNF862 zinc finger protein 862