tacrine-2633 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tacrine-2633 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB1 adhesion G protein-coupled receptor B1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK1 ankyrin 1, erythrocytic
ANPEP alanyl (membrane) aminopeptidase
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BMP6 bone morphogenetic protein 6
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
C11ORF63 chromosome 11 open reading frame 63
C1ORF61 chromosome 1 open reading frame 61
CA4 carbonic anhydrase IV
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD84 CD84 molecule
CFAP74 cilia and flagella associated protein 74
CLTA clathrin, light chain A
CPLX2 complexin 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSF cathepsin F
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DTX2 deltex 2, E3 ubiquitin ligase
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ETNK2 ethanolamine kinase 2
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FOXI1 forkhead box I1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPSM3 G-protein signaling modulator 3
GSDMB gasdermin B
GSTTP1 glutathione S-transferase theta pseudogene 1
HABP4 hyaluronan binding protein 4
HDAC11 histone deacetylase 11
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HLA-C major histocompatibility complex, class I, C
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGFBP3 insulin-like growth factor binding protein 3
INADL InaD-like (Drosophila)
IPO9 importin 9
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KITLG KIT ligand
KRT24 keratin 24, type I
LARP7 La ribonucleoprotein domain family, member 7
LIME1 Lck interacting transmembrane adaptor 1
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MARK4 MAP/microtubule affinity-regulating kinase 4
MKL1 megakaryoblastic leukemia (translocation) 1
MST1 macrophage stimulating 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MTM1 myotubularin 1
MXRA8 matrix-remodelling associated 8
MYF5 myogenic factor 5
NCAPH2 non-SMC condensin II complex, subunit H2
NCR2 natural cytotoxicity triggering receptor 2
NDN necdin, melanoma antigen (MAGE) family member
NOL12 nucleolar protein 12
NOP16 NOP16 nucleolar protein
NOS1 nitric oxide synthase 1 (neuronal)
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRG2 neuregulin 2
OMG oligodendrocyte myelin glycoprotein
PARVA parvin, alpha
PDAP1 PDGFA associated protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLAU plasminogen activator, urokinase
PLD2 phospholipase D2
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
QPCTL glutaminyl-peptide cyclotransferase-like
RAB30 RAB30, member RAS oncogene family
RBM5 RNA binding motif protein 5
RND1 Rho family GTPase 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS4Y1 ribosomal protein S4, Y-linked 1
SCHIP1 schwannomin interacting protein 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SIX1 SIX homeobox 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SND1-IT1 SND1 intronic transcript 1
SNTA1 syntrophin, alpha 1
SPAG8 sperm associated antigen 8
SPTAN1 spectrin, alpha, non-erythrocytic 1
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
UTRN utrophin
VEZT vezatin, adherens junctions transmembrane protein
WNT16 wingless-type MMTV integration site family, member 16
ZNF154 zinc finger protein 154

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ANKRD40 ankyrin repeat domain 40
ARHGAP10 Rho GTPase activating protein 10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
C11ORF30 chromosome 11 open reading frame 30
C2ORF54 chromosome 2 open reading frame 54
CBR3 carbonyl reductase 3
CCDC9 coiled-coil domain containing 9
CD79B CD79b molecule, immunoglobulin-associated beta
CDK20 cyclin-dependent kinase 20
CEP97 centrosomal protein 97kDa
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EGLN2 egl-9 family hypoxia-inducible factor 2
EML4 echinoderm microtubule associated protein like 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EXOC5 exocyst complex component 5
FAN1 FANCD2/FANCI-associated nuclease 1
FBXL4 F-box and leucine-rich repeat protein 4
FKBP14 FK506 binding protein 14, 22 kDa
FKBP5 FK506 binding protein 5
FSD1 fibronectin type III and SPRY domain containing 1
GAMT guanidinoacetate N-methyltransferase
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GRPR gastrin-releasing peptide receptor
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H2BO histone cluster 1, H2bo
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC10 homeobox C10
IFI35 interferon-induced protein 35
KLF11 Kruppel-like factor 11
KLHL25 kelch-like family member 25
KREMEN2 kringle containing transmembrane protein 2
LHFPL2 lipoma HMGIC fusion partner-like 2
LOC390998 ribosomal protein L10 pseudogene
MBTPS2 membrane-bound transcription factor peptidase, site 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP9 matrix metallopeptidase 9
MOCS3 molybdenum cofactor synthesis 3
MRPL2 mitochondrial ribosomal protein L2
MT1HL1 metallothionein 1H-like 1
MXD3 MAX dimerization protein 3
MYLIP myosin regulatory light chain interacting protein
MYO1F myosin IF
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NEK11 NIMA-related kinase 11
NPM3 nucleophosmin/nucleoplasmin 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PARP12 poly (ADP-ribose) polymerase family, member 12
PCSK7 proprotein convertase subtilisin/kexin type 7
PHC1 polyhomeotic homolog 1 (Drosophila)
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PMP22 peripheral myelin protein 22
PPAP2C phosphatidic acid phosphatase type 2C
PRSS22 protease, serine, 22
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RPAP2 RNA polymerase II associated protein 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX3 SRY (sex determining region Y)-box 3
SPIDR scaffolding protein involved in DNA repair
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
TICAM1 toll-like receptor adaptor molecule 1
TMC7 transmembrane channel-like 7
TMEM180 transmembrane protein 180
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
TSPYL2 TSPY-like 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
ULBP2 UL16 binding protein 2
USP20 ubiquitin specific peptidase 20
VAX2 ventral anterior homeobox 2
VWA1 von Willebrand factor A domain containing 1
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF250 zinc finger protein 250
ZNF446 zinc finger protein 446
ZNF669 zinc finger protein 669
ZNF767P zinc finger family member 767, pseudogene