tanespimycin-1225 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tanespimycin-1225 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDOB aldolase B, fructose-bisphosphate
APOE apolipoprotein E
BAG3 BCL2-associated athanogene 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BTBD7 BTB (POZ) domain containing 7
C17ORF80 chromosome 17 open reading frame 80
CA5BP1 carbonic anhydrase VB pseudogene 1
CABIN1 calcineurin binding protein 1
CALR calreticulin
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREBZF CREB/ATF bZIP transcription factor
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIDO1 death inducer-obliterator 1
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EML2 echinoderm microtubule associated protein like 2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ESRRG estrogen-related receptor gamma
FBN2 fibrillin 2
FKBP4 FK506 binding protein 4, 59kDa
FN1 fibronectin 1
FOXJ3 forkhead box J3
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR4 G protein-coupled receptor 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA4 homeobox A4
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IL7R interleukin 7 receptor
ITSN1 intersectin 1 (SH3 domain protein)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRT6A keratin 6A, type II
LAMA4 laminin, alpha 4
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K7CL MAP3K7 C-terminal like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NACA nascent polypeptide-associated complex alpha subunit
NAGLU N-acetylglucosaminidase, alpha
NAP1L2 nucleosome assembly protein 1-like 2
NPR3 natriuretic peptide receptor 3
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OASL 2'-5'-oligoadenylate synthetase-like
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE12 phosphodiesterase 12
PDZD2 PDZ domain containing 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G10 phospholipase A2, group X
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTGES prostaglandin E synthase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RFPL3 ret finger protein-like 3
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RPL10 ribosomal protein L10
SAT1 spermidine/spermine N1-acetyltransferase 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STIP1 stress-induced phosphoprotein 1
STX16 syntaxin 16
STX7 syntaxin 7
SYNGR1 synaptogyrin 1
TGFB2 transforming growth factor, beta 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM231 transmembrane protein 231
TMEM63A transmembrane protein 63A
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
UGT8 UDP glycosyltransferase 8
VWA8 von Willebrand factor A domain containing 8
WDR25 WD repeat domain 25
WWOX WW domain containing oxidoreductase
ZBED2 zinc finger, BED-type containing 2
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
ANKRD36B ankyrin repeat domain 36B
ATAD2 ATPase family, AAA domain containing 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BBS7 Bardet-Biedl syndrome 7
BCORL1 BCL6 corepressor-like 1
BMP4 bone morphogenetic protein 4
C1ORF106 chromosome 1 open reading frame 106
C1ORF56 chromosome 1 open reading frame 56
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CARD8 caspase recruitment domain family, member 8
CLDN14 claudin 14
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTSK cathepsin K
DENND4B DENN/MADD domain containing 4B
DHRS11 dehydrogenase/reductase (SDR family) member 11
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSN1 DSN1, MIS12 kinetochore complex component
E2F8 E2F transcription factor 8
EGLN1 egl-9 family hypoxia-inducible factor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FAM222B family with sequence similarity 222, member B
FGF1 fibroblast growth factor 1 (acidic)
FZD3 frizzled class receptor 3
GBX2 gastrulation brain homeobox 2
GRAMD4 GRAM domain containing 4
HIST1H2AM histone cluster 1, H2am
HLA-J major histocompatibility complex, class I, J (pseudogene)
HLX H2.0-like homeobox
HMGA2 high mobility group AT-hook 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KIAA0895 KIAA0895
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT4 keratin 4, type II
LOC100127972 uncharacterized LOC100127972
LRRC6 leucine rich repeat containing 6
MCM3AP-AS1 MCM3AP antisense RNA 1
MEX3C mex-3 RNA binding family member C
MFSD12 major facilitator superfamily domain containing 12
MICALL2 MICAL-like 2
MOXD1 monooxygenase, DBH-like 1
MXRA8 matrix-remodelling associated 8
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOL12 nucleolar protein 12
NRGN neurogranin (protein kinase C substrate, RC3)
OVGP1 oviductal glycoprotein 1, 120kDa
PAQR4 progestin and adipoQ receptor family member IV
PCF11 PCF11 cleavage and polyadenylation factor subunit
PEX13 peroxisomal biogenesis factor 13
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POMT1 protein-O-mannosyltransferase 1
PRKX protein kinase, X-linked
PRPH peripherin
PRR15L proline rich 15-like
PTK6 protein tyrosine kinase 6
RBM14 RNA binding motif protein 14
RECQL4 RecQ protein-like 4
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPAP2 RNA polymerase II associated protein 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SFT2D2 SFT2 domain containing 2
SIM2 single-minded family bHLH transcription factor 2
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SOWAHC sosondowah ankyrin repeat domain family member C
SPATA2L spermatogenesis associated 2-like
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STIM1 stromal interaction molecule 1
TDRD7 tudor domain containing 7
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMBIM1 transmembrane BAX inhibitor motif containing 1
TRIM9 tripartite motif containing 9
TTLL12 tubulin tyrosine ligase-like family member 12
TUFT1 tuftelin 1
USP18 ubiquitin specific peptidase 18
XYLT2 xylosyltransferase II
ZBTB44 zinc finger and BTB domain containing 44
ZMYM3 zinc finger, MYM-type 3
ZNF107 zinc finger protein 107
ZNF143 zinc finger protein 143
ZNF189 zinc finger protein 189
ZNF232 zinc finger protein 232
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF354A zinc finger protein 354A
ZNF84 zinc finger protein 84
ZSCAN5A zinc finger and SCAN domain containing 5A