tanespimycin-1650 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tanespimycin-1650 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABHD17B abhydrolase domain containing 17B
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOE apolipoprotein E
APOLD1 apolipoprotein L domain containing 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARTN artemin
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF7IP activating transcription factor 7 interacting protein
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAHCC1 BAH domain and coiled-coil containing 1
BAIAP2 BAI1-associated protein 2
BMP10 bone morphogenetic protein 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
CNOT4 CCR4-NOT transcription complex, subunit 4
CORT cortistatin
CTNS cystinosin, lysosomal cystine transporter
DBT dihydrolipoamide branched chain transacylase E2
DFNB31 deafness, autosomal recessive 31
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
EFHD1 EF-hand domain family, member D1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERO1L ERO1-like (S. cerevisiae)
EVA1B eva-1 homolog B (C. elegans)
FAM134B family with sequence similarity 134, member B
FBXO22 F-box protein 22
FLOT1 flotillin 1
FSCN1 fascin actin-bundling protein 1
GLP1R glucagon-like peptide 1 receptor
GOLGA2 golgin A2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRPR gastrin-releasing peptide receptor
HIP1 huntingtin interacting protein 1
HIST1H4D histone cluster 1, H4d
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOMER3 homer scaffolding protein 3
HOXC10 homeobox C10
ICAM1 intercellular adhesion molecule 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIF2A kinesin heavy chain member 2A
KLF3 Kruppel-like factor 3 (basic)
KRT6B keratin 6B, type II
LIMK2 LIM domain kinase 2
LRP5L low density lipoprotein receptor-related protein 5-like
LYPD1 LY6/PLAUR domain containing 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP6D1 MAP6 domain containing 1
MAPK8 mitogen-activated protein kinase 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
METTL5 methyltransferase like 5
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MORN1 MORN repeat containing 1
MPPED2 metallophosphoesterase domain containing 2
MSL3 male-specific lethal 3 homolog (Drosophila)
NEB nebulin
NFIB nuclear factor I/B
NOX1 NADPH oxidase 1
PALM paralemmin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFB platelet-derived growth factor beta polypeptide
PHF21A PHD finger protein 21A
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POFUT1 protein O-fucosyltransferase 1
POLL polymerase (DNA directed), lambda
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
RBM5 RNA binding motif protein 5
RIN2 Ras and Rab interactor 2
SASH1 SAM and SH3 domain containing 1
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SMIM14 small integral membrane protein 14
SNX2 sorting nexin 2
SREBF2 sterol regulatory element binding transcription factor 2
SRPR signal recognition particle receptor (docking protein)
TMCC2 transmembrane and coiled-coil domain family 2
TOX4 TOX high mobility group box family member 4
TUBA3C tubulin, alpha 3c
TUBGCP3 tubulin, gamma complex associated protein 3
TWF1 twinfilin actin binding protein 1
VGF VGF nerve growth factor inducible
WDHD1 WD repeat and HMG-box DNA binding protein 1
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP36L2 ZFP36 ring finger protein-like 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF276 zinc finger protein 276
ZNF287 zinc finger protein 287
ZNF3 zinc finger protein 3
ZNF442 zinc finger protein 442
ZNF446 zinc finger protein 446
ZNF701 zinc finger protein 701

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACAD10 acyl-CoA dehydrogenase family, member 10
AFF4 AF4/FMR2 family, member 4
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANP32A-IT1 ANP32A intronic transcript 1
ASB9 ankyrin repeat and SOCS box containing 9
BAHD1 bromo adjacent homology domain containing 1
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C11ORF80 chromosome 11 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
C2ORF44 chromosome 2 open reading frame 44
CALCOCO1 calcium binding and coiled-coil domain 1
CAMTA2 calmodulin binding transcription activator 2
CCDC9 coiled-coil domain containing 9
CEP170B centrosomal protein 170B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRY2 cryptochrome circadian clock 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSC cathepsin C
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTX4 deltex 4, E3 ubiquitin ligase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FANCE Fanconi anemia, complementation group E
FCHO1 FCH domain only 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALK1 galactokinase 1
GDAP2 ganglioside induced differentiation associated protein 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMHA1 histocompatibility (minor) HA-1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IGFBP6 insulin-like growth factor binding protein 6
IL15RA interleukin 15 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IP6K1 inositol hexakisphosphate kinase 1
IRF2 interferon regulatory factor 2
KIAA0556 KIAA0556
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MIS18BP1 MIS18 binding protein 1
MVD mevalonate (diphospho) decarboxylase
MYO1E myosin IE
NBEAL2 neurobeachin-like 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
ODF2 outer dense fiber of sperm tails 2
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PARD6A par-6 family cell polarity regulator alpha
PLD3 phospholipase D family, member 3
POLH polymerase (DNA directed), eta
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRMT7 protein arginine methyltransferase 7
RANBP17 RAN binding protein 17
RFTN1 raftlin, lipid raft linker 1
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF123 ring finger protein 123
RNF170 ring finger protein 170
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP2 RNA polymerase II associated protein 2
RWDD2A RWD domain containing 2A
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SIL1 SIL1 nucleotide exchange factor
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35F5 solute carrier family 35, member F5
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SNUPN snurportin 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG4 sperm associated antigen 4
SUN2 Sad1 and UNC84 domain containing 2
TCTN1 tectonic family member 1
THRAP3 thyroid hormone receptor associated protein 3
TLN1 talin 1
TMEM110 transmembrane protein 110
TPST1 tyrosylprotein sulfotransferase 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XAB2 XPA binding protein 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC3H3 zinc finger CCCH-type containing 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF747 zinc finger protein 747