tanespimycin-428 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tanespimycin-428 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ADORA2B adenosine A2b receptor
ARRB2 arrestin, beta 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C1D C1D nuclear receptor corepressor
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CACYBP calcyclin binding protein
CADM3 cell adhesion molecule 3
CD44 CD44 molecule (Indian blood group)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CORT cortistatin
DCAF8 DDB1 and CUL4 associated factor 8
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DUSP3 dual specificity phosphatase 3
EHBP1L1 EH domain binding protein 1-like 1
EID1 EP300 interacting inhibitor of differentiation 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM134B family with sequence similarity 134, member B
FNDC3A fibronectin type III domain containing 3A
FURIN furin (paired basic amino acid cleaving enzyme)
GABPB1 GA binding protein transcription factor, beta subunit 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IDUA iduronidase, alpha-L-
JOSD1 Josephin domain containing 1
KIAA1598
MED13L mediator complex subunit 13-like
MFAP2 microfibrillar-associated protein 2
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRC2 mannose receptor, C type 2
MRPS31 mitochondrial ribosomal protein S31
MYT1 myelin transcription factor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NDC80 NDC80 kinetochore complex component
NFIB nuclear factor I/B
NIPBL Nipped-B homolog (Drosophila)
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPOLA poly(A) polymerase alpha
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNPLA6 patatin-like phospholipase domain containing 6
PPP1R8 protein phosphatase 1, regulatory subunit 8
PSPH phosphoserine phosphatase
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RBM26 RNA binding motif protein 26
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPS11 ribosomal protein S11
RPS2 ribosomal protein S2
RRAS related RAS viral (r-ras) oncogene homolog
RRBP1 ribosome binding protein 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC23A Sec23 homolog A (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPC surfactant protein C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP23 synaptosomal-associated protein, 23kDa
SSR1 signal sequence receptor, alpha
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
T T, brachyury homolog (mouse)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TMED5 transmembrane emp24 protein transport domain containing 5
TMED7 transmembrane emp24 protein transport domain containing 7
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2A tubulin, beta 2A class IIa
VPS33B vacuolar protein sorting 33 homolog B (yeast)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YIPF6 Yip1 domain family, member 6
YLPM1 YLP motif containing 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF117 zinc finger protein 117
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAM15 ADAM metallopeptidase domain 15
ADAM23 ADAM metallopeptidase domain 23
ADAMTSL4 ADAMTS-like 4
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARRB1 arrestin, beta 1
BAHD1 bromo adjacent homology domain containing 1
C1ORF35 chromosome 1 open reading frame 35
C4ORF19 chromosome 4 open reading frame 19
CA5A carbonic anhydrase VA, mitochondrial
CA7 carbonic anhydrase VII
CCDC64 coiled-coil domain containing 64
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD82 CD82 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEP70 centrosomal protein 70kDa
CFAP70 cilia and flagella associated protein 70
CHRM4 cholinergic receptor, muscarinic 4
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLDN7 claudin 7
CLEC10A C-type lectin domain family 10, member A
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CSAD cysteine sulfinic acid decarboxylase
DCAF16 DDB1 and CUL4 associated factor 16
DSCAM Down syndrome cell adhesion molecule
EFCAB1 EF-hand calcium binding domain 1
EGLN1 egl-9 family hypoxia-inducible factor 1
ELP3 elongator acetyltransferase complex subunit 3
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM155B family with sequence similarity 155, member B
FJX1 four jointed box 1 (Drosophila)
GPA33 glycoprotein A33 (transmembrane)
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRWD1 glutamate-rich WD repeat containing 1
HOXA4 homeobox A4
HS1BP3 HCLS1 binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFNA10 interferon, alpha 10
JUNB jun B proto-oncogene
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KIAA0509 uncharacterized LOC57242
KLF15 Kruppel-like factor 15
LENEP lens epithelial protein
LGALS13 lectin, galactoside-binding, soluble, 13
LOC642236 FSHD region gene 1 pseudogene
MAN2C1 mannosidase, alpha, class 2C, member 1
MAPK3 mitogen-activated protein kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCHR1 melanin-concentrating hormone receptor 1
MMP3 matrix metallopeptidase 3
MNX1 motor neuron and pancreas homeobox 1
MVD mevalonate (diphospho) decarboxylase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOL6 nucleolar protein 6 (RNA-associated)
NUP93 nucleoporin 93kDa
NXPH3 neurexophilin 3
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCDHB6 protocadherin beta 6
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU4F2 POU class 4 homeobox 2
PRKCD protein kinase C, delta
PTPRT protein tyrosine phosphatase, receptor type, T
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L RAD54-like (S. cerevisiae)
RDH8 retinol dehydrogenase 8 (all-trans)
REEP4 receptor accessory protein 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RPS4Y1 ribosomal protein S4, Y-linked 1
SCIN scinderin
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC26A10 solute carrier family 26, member 10
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SYTL2 synaptotagmin-like 2
TEFM transcription elongation factor, mitochondrial
TFRC transferrin receptor
TMPRSS5 transmembrane protease, serine 5
TPST2 tyrosylprotein sulfotransferase 2
TRAV8-3 T cell receptor alpha variable 8-3
TSNAXIP1 translin-associated factor X interacting protein 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR46 WD repeat domain 46
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF747 zinc finger protein 747