tanespimycin-505 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tanespimycin-505 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AGTR2 angiotensin II receptor, type 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AMT aminomethyltransferase
ANKMY2 ankyrin repeat and MYND domain containing 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BAG3 BCL2-associated athanogene 3
BID BH3 interacting domain death agonist
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CACYBP calcyclin binding protein
CALB2 calbindin 2
CCPG1 cell cycle progression 1
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CDK19 cyclin-dependent kinase 19
CEP41 centrosomal protein 41kDa
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CINP cyclin-dependent kinase 2 interacting protein
CLIC5 chloride intracellular channel 5
CLK1 CDC-like kinase 1
COG5 component of oligomeric golgi complex 5
CRBN cereblon
CRYZ crystallin, zeta (quinone reductase)
CTSZ cathepsin Z
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EGF epidermal growth factor
FBXO2 F-box protein 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FST follistatin
FXR2 fragile X mental retardation, autosomal homolog 2
GPN1 GPN-loop GTPase 1
GSTCD glutathione S-transferase, C-terminal domain containing
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL17RC interleukin 17 receptor C
IL2RA interleukin 2 receptor, alpha
KIAA0040 KIAA0040
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLK6 kallikrein-related peptidase 6
KPNB1 karyopherin (importin) beta 1
LMAN1 lectin, mannose-binding, 1
LPP LIM domain containing preferred translocation partner in lipoma
LRIF1 ligand dependent nuclear receptor interacting factor 1
LUZP1 leucine zipper protein 1
LUZP4 leucine zipper protein 4
MAST4 microtubule associated serine/threonine kinase family member 4
MBNL2 muscleblind-like splicing regulator 2
MICB MHC class I polypeptide-related sequence B
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MST1 macrophage stimulating 1
MSX1 msh homeobox 1
NACA nascent polypeptide-associated complex alpha subunit
NADK NAD kinase
NDRG2 NDRG family member 2
NEU3 sialidase 3 (membrane sialidase)
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NPAT nuclear protein, ataxia-telangiectasia locus
OSBPL1A oxysterol binding protein-like 1A
PDE4DIP phosphodiesterase 4D interacting protein
PRB1 proline-rich protein BstNI subfamily 1
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCQ protein kinase C, theta
PRSS16 protease, serine, 16 (thymus)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RBKS ribokinase
RBM4B RNA binding motif protein 4B
RBM5 RNA binding motif protein 5
RFPL2 ret finger protein-like 2
RGR retinal G protein coupled receptor
RGS2 regulator of G-protein signaling 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
SEC23B Sec23 homolog B (S. cerevisiae)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STK25 serine/threonine kinase 25
SYNGR2 synaptogyrin 2
SYT2 synaptotagmin II
TUBBP5 tubulin, beta pseudogene 5
VASP vasodilator-stimulated phosphoprotein
WASL Wiskott-Aldrich syndrome-like
YIPF2 Yip1 domain family, member 2
ZC3H7B zinc finger CCCH-type containing 7B
ZNF227 zinc finger protein 227
ZNF419 zinc finger protein 419
ZNF460 zinc finger protein 460
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
AHCTF1 AT hook containing transcription factor 1
ANXA2P3 annexin A2 pseudogene 3
APOC2 apolipoprotein C-II
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATXN2 ataxin 2
BCL7C B-cell CLL/lymphoma 7C
BCL9 B-cell CLL/lymphoma 9
C19ORF40 chromosome 19 open reading frame 40
C5ORF30 chromosome 5 open reading frame 30
C9ORF40 chromosome 9 open reading frame 40
CAMKV CaM kinase-like vesicle-associated
CCP110 centriolar coiled coil protein 110kDa
CDKL3 cyclin-dependent kinase-like 3
CDKN2AIP CDKN2A interacting protein
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CLDN15 claudin 15
CYBRD1 cytochrome b reductase 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DLX2 distal-less homeobox 2
EFNA1 ephrin-A1
EGR3 early growth response 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOSC9 exosome component 9
EYA3 EYA transcriptional coactivator and phosphatase 3
FBRS fibrosin
FJX1 four jointed box 1 (Drosophila)
FOLR2 folate receptor 2 (fetal)
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
HELLS helicase, lymphoid-specific
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFNA7 interferon, alpha 7
IGFLR1 IGF-like family receptor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0319L KIAA0319-like
KIFC1 kinesin family member C1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAMA1 laminin, alpha 1
LIMS2 LIM and senescent cell antigen-like domains 2
LRP3 low density lipoprotein receptor-related protein 3
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MEX3C mex-3 RNA binding family member C
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC3 myosin binding protein C, cardiac
NCKAP1L NCK-associated protein 1-like
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPDC1 neural proliferation, differentiation and control, 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR6 progestin and adipoQ receptor family member VI
PF4 platelet factor 4
PHF21A PHD finger protein 21A
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PODXL podocalyxin-like
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
RAB3A RAB3A, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RFWD3 ring finger and WD repeat domain 3
RND3 Rho family GTPase 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SH2B2 SH2B adaptor protein 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SNAI2 snail family zinc finger 2
SOBP sine oculis binding protein homolog (Drosophila)
SOD3 superoxide dismutase 3, extracellular
SPRY2 sprouty homolog 2 (Drosophila)
SPX spexin hormone
STAB2 stabilin 2
STXBP2 syntaxin binding protein 2
SURF2 surfeit 2
TBC1D31 TBC1 domain family, member 31
TBP TATA box binding protein
TMEM8B transmembrane protein 8B
TMPRSS5 transmembrane protease, serine 5
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
TRIM8 tripartite motif containing 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTR transthyretin
UBE2O ubiquitin-conjugating enzyme E2O
ZNF408 zinc finger protein 408
ZXDC ZXD family zinc finger C