tanespimycin-5215 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tanespimycin-5215 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADCY7 adenylate cyclase 7
ADM adrenomedullin
ATXN1 ataxin 1
BAG2 BCL2-associated athanogene 2
BIN1 bridging integrator 1
BLZF1 basic leucine zipper nuclear factor 1
BMP4 bone morphogenetic protein 4
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BST2 bone marrow stromal cell antigen 2
C11ORF73 chromosome 11 open reading frame 73
CA4 carbonic anhydrase IV
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC81 coiled-coil domain containing 81
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRY2 cryptochrome circadian clock 2
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIDO1 death inducer-obliterator 1
DIO2 deiodinase, iodothyronine, type II
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK10 dedicator of cytokinesis 10
EDRF1 erythroid differentiation regulatory factor 1
FASTKD2 FAST kinase domains 2
FGFR2 fibroblast growth factor receptor 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSF2 heat shock transcription factor 2
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICA1 islet cell autoantigen 1, 69kDa
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLK6 kallikrein-related peptidase 6
KRT16 keratin 16, type I
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICB MHC class I polypeptide-related sequence B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NF1 neurofibromin 1
NLRX1 NLR family member X1
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGF placental growth factor
PLCD1 phospholipase C, delta 1
PPID peptidylprolyl isomerase D
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAI2 retinoic acid induced 2
RCAN1 regulator of calcineurin 1
RFPL2 ret finger protein-like 2
RFPL3 ret finger protein-like 3
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SEC24D SEC24 family member D
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3GL3 SH3-domain GRB2-like 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNAP23 synaptosomal-associated protein, 23kDa
SRCAP Snf2-related CREBBP activator protein
SRSF5 serine/arginine-rich splicing factor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STIP1 stress-induced phosphoprotein 1
STYK1 serine/threonine/tyrosine kinase 1
TES testin LIM domain protein
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM2 tripartite motif containing 2
TUBA3C tubulin, alpha 3c
ULBP2 UL16 binding protein 2
VLDLR very low density lipoprotein receptor
YY2 YY2 transcription factor
ZEB1 zinc finger E-box binding homeobox 1
ZFP37 ZFP37 zinc finger protein
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ANKRD36B ankyrin repeat domain 36B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATF3 activating transcription factor 3
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C9ORF3 chromosome 9 open reading frame 3
CBX7 chromobox homolog 7
CCDC88C coiled-coil domain containing 88C
CD3EAP CD3e molecule, epsilon associated protein
CDR2L cerebellar degeneration-related protein 2-like
CFAP44 cilia and flagella associated protein 44
CHPF chondroitin polymerizing factor
CISH cytokine inducible SH2-containing protein
CLCN2 chloride channel, voltage-sensitive 2
CLDN9 claudin 9
COA7 cytochrome c oxidase assembly factor 7 (putative)
CUL9 cullin 9
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP8 dual specificity phosphatase 8
DVL1 dishevelled segment polarity protein 1
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGR3 early growth response 3
EPN3 epsin 3
ERCC4 excision repair cross-complementation group 4
ESRP2 epithelial splicing regulatory protein 2
EVPL envoplakin
FAM155B family with sequence similarity 155, member B
GPR19 G protein-coupled receptor 19
HIST1H2AJ histone cluster 1, H2aj
HOXC10 homeobox C10
HOXC13 homeobox C13
HS1BP3 HCLS1 binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL17RB interleukin 17 receptor B
JUNB jun B proto-oncogene
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLF10 Kruppel-like factor 10
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMA3 laminin, alpha 3
LIN7B lin-7 homolog B (C. elegans)
LINC00115 long intergenic non-protein coding RNA 115
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LYPD1 LY6/PLAUR domain containing 1
MBNL3 muscleblind-like splicing regulator 3
MICALL2 MICAL-like 2
MID1IP1 MID1 interacting protein 1
MNX1 motor neuron and pancreas homeobox 1
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPL2 nucleoporin like 2
NXT1 nuclear transport factor 2-like export factor 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARD6A par-6 family cell polarity regulator alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PRKCD protein kinase C, delta
RBM14 RNA binding motif protein 14
RGS16 regulator of G-protein signaling 16
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SLC12A9 solute carrier family 12, member 9
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SMAD7 SMAD family member 7
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOWAHC sosondowah ankyrin repeat domain family member C
SPATA2L spermatogenesis associated 2-like
SPHK1 sphingosine kinase 1
SPIDR scaffolding protein involved in DNA repair
SPRY2 sprouty homolog 2 (Drosophila)
SYTL2 synaptotagmin-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM120B transmembrane protein 120B
TMEM159 transmembrane protein 159
TMEM180 transmembrane protein 180
TRAPPC12 trafficking protein particle complex 12
ULK1 unc-51 like autophagy activating kinase 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF205 zinc finger protein 205
ZNF446 zinc finger protein 446
ZNF580 zinc finger protein 580
ZNF669 zinc finger protein 669
ZNF692 zinc finger protein 692
ZXDC ZXD family zinc finger C