tanespimycin-5566 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tanespimycin-5566 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
AFF2 AF4/FMR2 family, member 2
AGMAT agmatine ureohydrolase (agmatinase)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMPD3 adenosine monophosphate deaminase 3
BAG2 BCL2-associated athanogene 2
BIN1 bridging integrator 1
BLZF1 basic leucine zipper nuclear factor 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CARD10 caspase recruitment domain family, member 10
CCNG2 cyclin G2
CCR9 chemokine (C-C motif) receptor 9
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC4E C-type lectin domain family 4, member E
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A1 collagen, type I, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPQ carboxypeptidase Q
CSRP2 cysteine and glycine-rich protein 2
DBF4B DBF4 zinc finger B
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DRD1 dopamine receptor D1
EGF epidermal growth factor
ERO1LB ERO1-like beta (S. cerevisiae)
FAM46C family with sequence similarity 46, member C
FGFR2 fibroblast growth factor receptor 2
FH fumarate hydratase
GALR3 galanin receptor 3
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFT27 intraflagellar transport 27
IL2RG interleukin 2 receptor, gamma
IL6R interleukin 6 receptor
MAP1B microtubule-associated protein 1B
MAPK10 mitogen-activated protein kinase 10
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL16 methyltransferase like 16
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSC musculin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
N4BP2L2 NEDD4 binding protein 2-like 2
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA4 protein disulfide isomerase family A, member 4
PGF placental growth factor
PLA2G3 phospholipase A2, group III
PRB1 proline-rich protein BstNI subfamily 1
PRSS16 protease, serine, 16 (thymus)
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RFPL2 ret finger protein-like 2
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35F5 solute carrier family 35, member F5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SRCAP Snf2-related CREBBP activator protein
STIP1 stress-induced phosphoprotein 1
STYK1 serine/threonine/tyrosine kinase 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TES testin LIM domain protein
TRBC1 T cell receptor beta constant 1
TREX1 three prime repair exonuclease 1
ULBP2 UL16 binding protein 2
UNC93A unc-93 homolog A (C. elegans)
VLDLR very low density lipoprotein receptor
WDR59 WD repeat domain 59
ZFP37 ZFP37 zinc finger protein
ZNF10 zinc finger protein 10
ZNF136 zinc finger protein 136
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235
ZNF280A zinc finger protein 280A

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
ANP32A-IT1 ANP32A intronic transcript 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG9A autophagy related 9A
B9D2 B9 protein domain 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C10ORF2 chromosome 10 open reading frame 2
C11ORF30 chromosome 11 open reading frame 30
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
CALHM2 calcium homeostasis modulator 2
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRYBG3 beta-gamma crystallin domain containing 3
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNAAF2 dynein, axonemal, assembly factor 2
DNMBP dynamin binding protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP2 dual specificity phosphatase 2
EGR3 early growth response 3
EPPK1 epiplakin 1
ERCC4 excision repair cross-complementation group 4
ESRP2 epithelial splicing regulatory protein 2
EXD3 exonuclease 3'-5' domain containing 3
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAS8 growth arrest-specific 8
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR19 G protein-coupled receptor 19
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HAUS6 HAUS augmin-like complex, subunit 6
HDAC4 histone deacetylase 4
HIST1H1D histone cluster 1, H1d
HOXA4 homeobox A4
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
JUNB jun B proto-oncogene
KRT13 keratin 13, type I
LAMP3 lysosomal-associated membrane protein 3
LIN7A lin-7 homolog A (C. elegans)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC37A3 leucine rich repeat containing 37, member A3
LYPD1 LY6/PLAUR domain containing 1
MAP1S microtubule-associated protein 1S
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPKBP1 mitogen-activated protein kinase binding protein 1
MATK megakaryocyte-associated tyrosine kinase
MID1IP1 MID1 interacting protein 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPIPB3 nuclear pore complex interacting protein family, member B3
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
POMT2 protein-O-mannosyltransferase 2
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKCD protein kinase C, delta
PRPH peripherin
PTDSS2 phosphatidylserine synthase 2
PTPRU protein tyrosine phosphatase, receptor type, U
PYCRL pyrroline-5-carboxylate reductase-like
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RPGR retinitis pigmentosa GTPase regulator
SLC12A8 solute carrier family 12, member 8
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMAD7 SMAD family member 7
SNHG3 small nucleolar RNA host gene 3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM180 transmembrane protein 180
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
ULK1 unc-51 like autophagy activating kinase 1
USP36 ubiquitin specific peptidase 36
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF747 zinc finger protein 747
ZXDC ZXD family zinc finger C