tanespimycin-5586 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tanespimycin-5586 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADCY7 adenylate cyclase 7
AMPD3 adenosine monophosphate deaminase 3
ANG angiogenin, ribonuclease, RNase A family, 5
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ATAT1 alpha tubulin acetyltransferase 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BST2 bone marrow stromal cell antigen 2
CA4 carbonic anhydrase IV
CALCR calcitonin receptor
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCA1 chloride channel accessory 1
CNN1 calponin 1, basic, smooth muscle
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP2 cysteine and glycine-rich protein 2
DBF4B DBF4 zinc finger B
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EDNRA endothelin receptor type A
EGF epidermal growth factor
FAM46C family with sequence similarity 46, member C
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GGT1 gamma-glutamyltransferase 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IL2RB interleukin 2 receptor, beta
IL6R interleukin 6 receptor
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIFC3 kinesin family member C3
KLK12 kallikrein-related peptidase 12
LDB3 LIM domain binding 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MORC1 MORC family CW-type zinc finger 1
MPPE1 metallophosphoesterase 1
NMBR neuromedin B receptor
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDHGA10 protocadherin gamma subfamily A, 10
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PGF placental growth factor
PLA2G3 phospholipase A2, group III
PNPLA3 patatin-like phospholipase domain containing 3
POPDC3 popeye domain containing 3
PQBP1 polyglutamine binding protein 1
PRB1 proline-rich protein BstNI subfamily 1
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTCRA pre T-cell antigen receptor alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDC1 PX domain containing 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RETN resistin
RFPL2 ret finger protein-like 2
RGS2 regulator of G-protein signaling 2
RPLP2 ribosomal protein, large, P2
SAMD4A sterile alpha motif domain containing 4A
SCARF1 scavenger receptor class F, member 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH2D3A SH2 domain containing 3A
SH3BGR SH3 domain binding glutamate-rich protein
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STS steroid sulfatase (microsomal), isozyme S
TBX3 T-box 3
THSD4 thrombospondin, type I, domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNK2 tyrosine kinase, non-receptor, 2
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTLL7 tubulin tyrosine ligase-like family member 7
TUBA3C tubulin, alpha 3c
UPK1B uroplakin 1B
YY2 YY2 transcription factor
ZNF10 zinc finger protein 10
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD36 ankyrin repeat domain 36
ANP32A-IT1 ANP32A intronic transcript 1
AXIN1 axin 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C11ORF30 chromosome 11 open reading frame 30
C1ORF56 chromosome 1 open reading frame 56
C4ORF19 chromosome 4 open reading frame 19
C9ORF3 chromosome 9 open reading frame 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNO cyclin O
CD302 CD302 molecule
CDR2L cerebellar degeneration-related protein 2-like
CENPT centromere protein T
CFAP44 cilia and flagella associated protein 44
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNMBP dynamin binding protein
DUSP2 dual specificity phosphatase 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGR3 early growth response 3
ERCC4 excision repair cross-complementation group 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F8 coagulation factor VIII, procoagulant component
FBRS fibrosin
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR19 G protein-coupled receptor 19
HOXA4 homeobox A4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL17RB interleukin 17 receptor B
ITPKB inositol-trisphosphate 3-kinase B
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LIN7A lin-7 homolog A (C. elegans)
LINC00115 long intergenic non-protein coding RNA 115
LINC00339 long intergenic non-protein coding RNA 339
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
METTL1 methyltransferase like 1
MNT MAX network transcriptional repressor
MOAP1 modulator of apoptosis 1
MOGS mannosyl-oligosaccharide glucosidase
MTHFSD methenyltetrahydrofolate synthetase domain containing
MVD mevalonate (diphospho) decarboxylase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY5R neuropeptide Y receptor Y5
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCYOX1L prenylcysteine oxidase 1 like
PGBD5 piggyBac transposable element derived 5
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKCD protein kinase C, delta
PUS1 pseudouridylate synthase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RECQL4 RecQ protein-like 4
RGS16 regulator of G-protein signaling 16
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIC8B RIC8 guanine nucleotide exchange factor B
RPL23AP32 ribosomal protein L23a pseudogene 32
SACS sacsin molecular chaperone
SCO2 SCO2 cytochrome c oxidase assembly protein
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SHROOM2 shroom family member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMAD7 SMAD family member 7
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM62 transmembrane protein 62
TRIB1 tribbles pseudokinase 1
TRMT61B tRNA methyltransferase 61B
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF286A zinc finger protein 286A
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862
ZSCAN5A zinc finger and SCAN domain containing 5A
ZXDC ZXD family zinc finger C