tanespimycin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A 19-membered macrocyle comprising geldanamycin with its 17-methoxy substituent replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumor effects. (Chemical Entities of Biological Interest Ontology, CHEBI_64153)
External Link http://ctdbase.org/detail.go?type=chem&acc=C112765
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Genes

47 genes/proteins interacting with the chemical tanespimycin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALK anaplastic lymphoma receptor tyrosine kinase
APAF1 apoptotic peptidase activating factor 1
AR androgen receptor
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDK8 cyclin-dependent kinase 8
COMMD1 copper metabolism (Murr1) domain containing 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR3 fibroblast growth factor receptor 3
FLT3 fms-related tyrosine kinase 3
GSK3B glycogen synthase kinase 3 beta
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
PGR progesterone receptor
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RPS6 ribosomal protein S6
SOD2 superoxide dismutase 2, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TYMS thymidylate synthetase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase