tbk1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TANK-binding kinase 1|The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 29110)
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Genes

39 genes co-occuring with the biological term tbk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CALCOCO2 calcium binding and coiled-coil domain 2
CHUK conserved helix-loop-helix ubiquitous kinase
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DTX4 deltex 4, E3 ubiquitin ligase
ESR1 estrogen receptor 1
GSK3B glycogen synthase kinase 3 beta
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFN1@ interferon, type 1, cluster
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1A interleukin 1, alpha
IL23A interleukin 23, alpha subunit p19
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
KRAS Kirsten rat sarcoma viral oncogene homolog
MAVS mitochondrial antiviral signaling protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NLRP4 NLR family, pyrin domain containing 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
OPTN optineurin
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIOK3 RIO kinase 3
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TMEM173 transmembrane protein 173
TREX1 three prime repair exonuclease 1
TRIM11 tripartite motif containing 11
USP2 ubiquitin specific peptidase 2
ZEB1 zinc finger E-box binding homeobox 1