tcf12_21972416_linnegflt3poscd127posly6dneg_bone_marrow_lof_mouse_gpl1261_gse27402 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27402
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Genes

269 genes differentially expressed following the tcf12_21972416_linnegflt3poscd127posly6dneg_bone_marrow_lof_mouse_gpl1261_gse27402 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
FBXW2 F-box and WD repeat domain containing 2 0.221315
THRAP3 thyroid hormone receptor associated protein 3 0.218418
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 0.217723
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.212257
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 0.210814
BRCA2 breast cancer 2, early onset 0.207695
EXOSC10 exosome component 10 0.207157
SIRT5 sirtuin 5 0.206197
PDIA5 protein disulfide isomerase family A, member 5 0.204127
PUS3 pseudouridylate synthase 3 0.199382
PIH1D2 PIH1 domain containing 2 0.199146
SCN1A sodium channel, voltage gated, type I alpha subunit 0.198749
RNASEH2B ribonuclease H2, subunit B 0.197734
MCPH1 microcephalin 1 0.192443
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.190343
MED14 mediator complex subunit 14 0.18882
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.188033
CDKL4 cyclin-dependent kinase-like 4 0.1877
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.187231
ALPK1 alpha-kinase 1 0.186084
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.185949
MRC2 mannose receptor, C type 2 0.182273
HEATR5B HEAT repeat containing 5B 0.176158
MAP2K4 mitogen-activated protein kinase kinase 4 0.17568
RECQL5 RecQ protein-like 5 0.173492
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.170963
CD22 CD22 molecule 0.170902
TYSND1 trypsin domain containing 1 0.164107
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.162781
SETD8 SET domain containing (lysine methyltransferase) 8 0.162235
AIM1 absent in melanoma 1 0.161669
KIAA1841 KIAA1841 0.158314
PRCP prolylcarboxypeptidase (angiotensinase C) 0.157651
ASCC2 activating signal cointegrator 1 complex subunit 2 0.152789
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.150509
USP34 ubiquitin specific peptidase 34 0.149734
VCAN versican 0.147732
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.14398
AEN apoptosis enhancing nuclease 0.136339
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.131938
EIF3I eukaryotic translation initiation factor 3, subunit I 0.126733
PROB1 proline-rich basic protein 1 0.124826
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.122111
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.119095
AHNAK2 AHNAK nucleoprotein 2 0.118333
SIN3A SIN3 transcription regulator family member A 0.111675
MCF2 MCF.2 cell line derived transforming sequence 0.110307
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.106282
ANXA2 annexin A2 0.105262
RHOBTB2 Rho-related BTB domain containing 2 0.102087
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.096782
ITFG1 integrin alpha FG-GAP repeat containing 1 0.09515
TRMT6 tRNA methyltransferase 6 0.091681
UGP2 UDP-glucose pyrophosphorylase 2 0.091517
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.091384
FAM213A family with sequence similarity 213, member A 0.091117
ARHGAP17 Rho GTPase activating protein 17 0.089402
IER2 immediate early response 2 0.084572
WNT2B wingless-type MMTV integration site family, member 2B 0.08217
PGRMC2 progesterone receptor membrane component 2 0.082039
GPR146 G protein-coupled receptor 146 0.081373
FAM170B family with sequence similarity 170, member B 0.079465
SDCCAG8 serologically defined colon cancer antigen 8 0.077167
OXT oxytocin/neurophysin I prepropeptide 0.077109
MRPL48 mitochondrial ribosomal protein L48 0.075922
RYR3 ryanodine receptor 3 0.074654
ALG6 ALG6, alpha-1,3-glucosyltransferase 0.072412
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.070129
CLSPN claspin 0.06497
TTC14 tetratricopeptide repeat domain 14 0.060205
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 0.056412
FAM104A family with sequence similarity 104, member A 0.056223
MBLAC1 metallo-beta-lactamase domain containing 1 0.05476
SOD2 superoxide dismutase 2, mitochondrial 0.053844
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.053694
FAM149A family with sequence similarity 149, member A 0.050947
PRKCD protein kinase C, delta 0.046483
RASL11B RAS-like, family 11, member B 0.045643
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.044522
MFN2 mitofusin 2 0.042717
PTCD3 pentatricopeptide repeat domain 3 0.042346
E2F6 E2F transcription factor 6 0.04226
PRR14 proline rich 14 0.041579
CS citrate synthase 0.038921
BEND7 BEN domain containing 7 0.038613
ZSWIM2 zinc finger, SWIM-type containing 2 0.038613
STAT5B signal transducer and activator of transcription 5B 0.031168
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.03046
NOL10 nucleolar protein 10 0.026925
KIAA1804 mixed lineage kinase 4 0.026285
SH2D3C SH2 domain containing 3C 0.024874
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.024714
ABHD12 abhydrolase domain containing 12 0.020513
JAM2 junctional adhesion molecule 2 0.019086
HTRA2 HtrA serine peptidase 2 0.018183
FAM183B acyloxyacyl hydrolase (neutrophil) 0.017722
DRAM1 DNA-damage regulated autophagy modulator 1 0.017696
C8B complement component 8, beta polypeptide 0.017235
NGFR nerve growth factor receptor 0.016493
ETV1 ets variant 1 0.014865
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.014007
MCOLN1 mucolipin 1 0.013982
THAP4 THAP domain containing 4 0.012623
GSTP1 glutathione S-transferase pi 1 0.012423
MAGOHB mago-nashi homolog B (Drosophila) 0.010853
VAMP8 vesicle-associated membrane protein 8 0.009222
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.008558
MICU2 mitochondrial calcium uptake 2 0.006072
SFMBT1 Scm-like with four mbt domains 1 0.001856
TRIM23 tripartite motif containing 23 0.001479
THY1 Thy-1 cell surface antigen 3.27E-4

decreased expression

Symbol Name Standardized Value
MPDZ multiple PDZ domain protein -1.28648
ESRRB estrogen-related receptor beta -1.28376
RPL35 ribosomal protein L35 -1.26208
BSPRY B-box and SPRY domain containing -1.25347
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -1.23472
SMIM7 small integral membrane protein 7 -1.22203
KLRC1 killer cell lectin-like receptor subfamily C, member 1 -1.21579
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 -1.18053
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 -1.17394
ERICH2 glutamate-rich 2 -1.16301
CCDC39 coiled-coil domain containing 39 -1.14832
TMEM139 transmembrane protein 139 -1.14349
FAM73B family with sequence similarity 73, member B -1.14265
PDE4B phosphodiesterase 4B, cAMP-specific -1.13708
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -1.10348
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -1.09198
MAP6 microtubule-associated protein 6 -1.07907
ARHGAP8 Rho GTPase activating protein 8 -1.07418
PPP1R15B protein phosphatase 1, regulatory subunit 15B -1.06628
IL17RC interleukin 17 receptor C -1.04251
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.971438
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 -0.970169
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 -0.964129
ENO1 enolase 1, (alpha) -0.951661
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -0.949326
SP8 Sp8 transcription factor -0.941783
RILPL2 Rab interacting lysosomal protein-like 2 -0.921616
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 -0.901945
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.901831
PRSS2 protease, serine, 2 (trypsin 2) -0.895626
KLHDC2 kelch domain containing 2 -0.885806
LIMCH1 LIM and calponin homology domains 1 -0.882851
HM13 histocompatibility (minor) 13 -0.84555
ANAPC10 anaphase promoting complex subunit 10 -0.844976
CDC73 cell division cycle 73 -0.842791
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.841496
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.83299
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.821706
PSAPL1 prosaposin-like 1 (gene/pseudogene) -0.817186
MAP2K7 mitogen-activated protein kinase kinase 7 -0.804206
MAP1A microtubule-associated protein 1A -0.802281
RGS9BP regulator of G protein signaling 9 binding protein -0.798601
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.785991
MPZL2 myelin protein zero-like 2 -0.779848
ZBTB20 zinc finger and BTB domain containing 20 -0.773562
LINGO1 leucine rich repeat and Ig domain containing 1 -0.770762
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.766105
ZFR zinc finger RNA binding protein -0.739538
EXOC6 exocyst complex component 6 -0.733904
HMG20A high mobility group 20A -0.732414
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -0.725529
SETD1A SET domain containing 1A -0.72346
AK5 adenylate kinase 5 -0.723379
ATAD2 ATPase family, AAA domain containing 2 -0.713626
ZBTB4 zinc finger and BTB domain containing 4 -0.7104
YTHDC1 YTH domain containing 1 -0.703406
RGN regucalcin -0.697672
TET2 tet methylcytosine dioxygenase 2 -0.693291
TMEM179B transmembrane protein 179B -0.676762
KIAA2022 KIAA2022 -0.670456
LAMB3 laminin, beta 3 -0.661102
NEUROD2 neuronal differentiation 2 -0.647474
CLDN7 claudin 7 -0.646011
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.631417
CERS3 ceramide synthase 3 -0.615307
MBNL2 muscleblind-like splicing regulator 2 -0.609242
CDK19 cyclin-dependent kinase 19 -0.603355
EDA ectodysplasin A -0.598213
APOL6 apolipoprotein L, 6 -0.598025
TM7SF3 transmembrane 7 superfamily member 3 -0.592913
RAB29 RAB29, member RAS oncogene family -0.589649
PAQR6 progestin and adipoQ receptor family member VI -0.586858
AFF4 AF4/FMR2 family, member 4 -0.585348
MRPL33 mitochondrial ribosomal protein L33 -0.568468
TCF12 transcription factor 12 -0.555974
ERO1LB ERO1-like beta (S. cerevisiae) -0.54546
RCOR3 REST corepressor 3 -0.544226
MTSS1 metastasis suppressor 1 -0.542382
LAMB1 laminin, beta 1 -0.531813
TSPAN8 tetraspanin 8 -0.530256
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -0.526187
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -0.525712
SPATA6 spermatogenesis associated 6 -0.525095
CIDEB cell death-inducing DFFA-like effector b -0.52462
LETMD1 LETM1 domain containing 1 -0.521864
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -0.520102
GJC1 gap junction protein, gamma 1, 45kDa -0.513566
MYLK2 myosin light chain kinase 2 -0.510646
GTPBP1 GTP binding protein 1 -0.508717
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -0.499586
CATSPER1 cation channel, sperm associated 1 -0.499258
JMJD4 jumonji domain containing 4 -0.496351
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.492496
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -0.490206
ATOH1 atonal homolog 1 (Drosophila) -0.485048
SAMD12 sterile alpha motif domain containing 12 -0.475688
EPHX3 epoxide hydrolase 3 -0.475511
MANEAL mannosidase, endo-alpha-like -0.474906
CAT catalase -0.473432
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.467858
ALB albumin -0.455835
AMMECR1L AMMECR1-like -0.452717
CENPE centromere protein E, 312kDa -0.448101
WDR43 WD repeat domain 43 -0.447654
RTP4 receptor (chemosensory) transporter protein 4 -0.444521
CDCA2 cell division cycle associated 2 -0.443876
SALL1 spalt-like transcription factor 1 -0.441706
ACE2 angiotensin I converting enzyme 2 -0.435034
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -0.434964
ZNF595 zinc finger protein 595 -0.433259
RBM20 RNA binding motif protein 20 -0.432543
MTMR4 myotubularin related protein 4 -0.432024
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.059651
MED31 mediator complex subunit 31 -0.055436
NONO non-POU domain containing, octamer-binding -0.053904
BRAP BRCA1 associated protein -0.049256
GRIP1 glutamate receptor interacting protein 1 -0.048325
SNX19 sorting nexin 19 -0.047537
YPEL1 yippee-like 1 (Drosophila) -0.047477
ALOX15 arachidonate 15-lipoxygenase -0.046603
KLHL28 kelch-like family member 28 -0.043621
MANBAL mannosidase, beta A, lysosomal-like -0.042875
PHB2 prohibitin 2 -0.041434
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -0.040261
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.038504
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -0.036906
SAP18 Sin3A-associated protein, 18kDa -0.035837
IL20RB interleukin 20 receptor beta -0.035193
SON SON DNA binding protein -0.034868
WHSC1 Wolf-Hirschhorn syndrome candidate 1 -0.030983
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -0.030304
NCEH1 neutral cholesterol ester hydrolase 1 -0.029995
SCUBE1 signal peptide, CUB domain, EGF-like 1 -0.029578
C1QL3 complement component 1, q subcomponent-like 3 -0.029072
TOM1 target of myb1 (chicken) -0.024438
SLN sarcolipin -0.023479
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -0.022941
NDOR1 NADPH dependent diflavin oxidoreductase 1 -0.022737
ELAC2 elaC ribonuclease Z 2 -0.022603
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) -0.02177
TBCB tubulin folding cofactor B -0.020351
C12ORF57 chromosome 12 open reading frame 57 -0.019649
CHN2 chimerin 2 -0.018384
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.018111
BCL2L13 BCL2-like 13 (apoptosis facilitator) -0.017884
IL11RA interleukin 11 receptor, alpha -0.016335
ALDOA aldolase A, fructose-bisphosphate -0.015492
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.011547
NME1 NME/NM23 nucleoside diphosphate kinase 1 -0.01111
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -0.01072
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -0.010142
CD83 CD83 molecule -0.009217
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.008318
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.007714
PKD1 polycystic kidney disease 1 (autosomal dominant) -0.007134
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -0.004974
ABLIM2 actin binding LIM protein family, member 2 -0.00488
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.00353
Funding