tert Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description telomerase reverse transcriptase|Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7015)
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Genes

73 genes co-occuring with the biological term tert in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACD adrenocortical dysplasia homolog (mouse)
ALOX15B arachidonate 15-lipoxygenase, type B
ATF7IP activating transcription factor 7 interacting protein
ATR ATR serine/threonine kinase
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CLPTM1L CLPTM1-like
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDB1 damage-specific DNA binding protein 1, 127kDa
DKC1 dyskeratosis congenita 1, dyskerin
DMRT1 doublesex and mab-3 related transcription factor 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGFR epidermal growth factor receptor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV1 ets variant 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSTP1 glutathione S-transferase pi 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL6 interleukin 6
JAK2 Janus kinase 2
MIR1207 microRNA 1207
MIR1266 microRNA 1266
MIR138-1 microRNA 138-1
MIR375 microRNA 375
MKI67 marker of proliferation Ki-67
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NONO non-POU domain containing, octamer-binding
NR5A2 nuclear receptor subfamily 5, group A, member 2
PITX1 paired-like homeodomain 1
POT1 protection of telomeres 1
PRKCA protein kinase C, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RMRP RNA component of mitochondrial RNA processing endoribonuclease
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SHH sonic hedgehog
SIRT1 sirtuin 1
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP1 Sp1 transcription factor
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TEP1 telomerase-associated protein 1
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TMSB10 thymosin beta 10
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP73 tumor protein p73
TRRAP transformation/transcription domain-associated protein
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VEGFA vascular endothelial growth factor A
VPRBP Vpr (HIV-1) binding protein
WT1 Wilms tumor 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB16 zinc finger and BTB domain containing 16