tertiary granule Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. (Gene Ontology, GO_0070820)
External Link http://amigo.geneontology.org/amigo/term/GO:0070820
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Genes

164 proteins localized to the tertiary granule cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM8 ADAM metallopeptidase domain 8
ADGRE3 adhesion G protein-coupled receptor E3
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
ALDOC aldolase C, fructose-bisphosphate
ANO6 anoctamin 6
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARL8A ADP-ribosylation factor-like 8A
ARMC8 armadillo repeat containing 8
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATAD3B ATPase family, AAA domain containing 3B
ATP11A ATPase, class VI, type 11A
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP8B4 ATPase, class I, type 8B, member 4
B2M beta-2-microglobulin
CANT1 calcium activated nucleotidase 1
CD177 CD177 molecule
CD300A CD300a molecule
CD33 CD33 molecule
CD47 CD47 molecule
CD53 CD53 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD93 CD93 molecule
CDA cytidine deaminase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CFP complement factor properdin
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHIT1 chitinase 1 (chitotriosidase)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLEC12A C-type lectin domain family 12, member A
CLEC4C C-type lectin domain family 4, member C
CLEC4D C-type lectin domain family 4, member D
CLEC5A C-type lectin domain family 5, member A
CNN2 calponin 2
COPB1 coatomer protein complex, subunit beta 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRISP3 cysteine-rich secretory protein 3
CST3 cystatin C
CSTB cystatin B (stefin B)
CTSD cathepsin D
CTSH cathepsin H
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYSTM1 cysteine-rich transmembrane module containing 1
DBNL drebrin-like
DIAPH1 diaphanous-related formin 1
DLC1 DLC1 Rho GTPase activating protein
DOK3 docking protein 3
DSG1 desmoglein 1
DSPP dentin sialophosphoprotein
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FCAR Fc fragment of IgA receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLG2 filaggrin family member 2
FOLR3 folate receptor 3 (gamma)
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FRMPD3 FERM and PDZ domain containing 3
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA7 golgin A7
GPR84 G protein-coupled receptor 84
GSDMD gasdermin D
HBB hemoglobin, beta
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
ILF2 interleukin enhancer binding factor 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LGALS3 lectin, galactoside-binding, soluble, 3
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOC112694756 uncharaterized LOC112694756
LRG1 leucine-rich alpha-2-glycoprotein 1
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
LYZ lysozyme
MCEMP1 mast cell-expressed membrane protein 1
MGAM maltase-glucoamylase
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
NBEAL2 neurobeachin-like 2
NCKAP1L NCK-associated protein 1-like
NFASC neurofascin
NIT2 nitrilase family, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
ORM1 orosomucoid 1
OSCAR osteoclast associated, immunoglobulin-like receptor
PGLYRP1 peptidoglycan recognition protein 1
PGM1 phosphoglucomutase 1
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKCSH protein kinase C substrate 80K-H
PRSS3 protease, serine, 3
PTAFR platelet-activating factor receptor
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB14 RAB14, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RCAN1 regulator of calcineurin 1
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SIGLEC14 sialic acid binding Ig-like lectin 14
SIGLEC5 sialic acid binding Ig-like lectin 5
SIRPA signal-regulatory protein alpha
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP23 synaptosomal-associated protein, 23kDa
SNAP25 synaptosomal-associated protein, 25kDa
SPTAN1 spectrin, alpha, non-erythrocytic 1
STBD1 starch binding domain 1
STOM stomatin
STX7 syntaxin 7
STXBP2 syntaxin binding protein 2
STXBP3 syntaxin binding protein 3
SVIP small VCP/p97-interacting protein
TARM1 T cell-interacting, activating receptor on myeloid cells 1
TBC1D10C TBC1 domain family, member 10C
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP2 TIMP metallopeptidase inhibitor 2
TMC6 transmembrane channel-like 6
TMEM179B transmembrane protein 179B
TMEM63A transmembrane protein 63A
TMT1A thiol methyltransferase 1A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN14 tetraspanin 14
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VPS35L VPS35 endosomal protein sorting factor like
YPEL5 yippee-like 5 (Drosophila)