tetanus Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli. (Experimental Factor Ontology, EFO_0005593)
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Genes

349 genes co-occuring with the disease tetanus in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DPT dermatopontin 2.58446
VAMP3 vesicle-associated membrane protein 3 2.21644
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.20149
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.12072
CD4 CD4 molecule 2.10424
NSF N-ethylmaleimide-sensitive factor 1.90335
CD79A CD79a molecule, immunoglobulin-associated alpha 1.82549
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 1.68816
IL2 interleukin 2 1.50403
CD86 CD86 molecule 1.44123
SNAP23 synaptosomal-associated protein, 23kDa 1.43464
STX3 syntaxin 3 1.35071
CD80 CD80 molecule 1.33676
STX4 syntaxin 4 1.29571
CD40 CD40 molecule, TNF receptor superfamily member 5 1.27257
PVALB parvalbumin 1.26516
CD83 CD83 molecule 1.24037
ALB albumin 1.23863
LGALS4 lectin, galactoside-binding, soluble, 4 1.23169
IL4 interleukin 4 1.20915
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 1.20483
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.17808
CD58 CD58 molecule 1.16949
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.1524
CD19 CD19 molecule 1.05639
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 1.05471
SYN1 synapsin I 1.05219
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.0484
MGAM maltase-glucoamylase 1.04335
NELFCD negative elongation factor complex member C/D 1.03914
NGF nerve growth factor (beta polypeptide) 1.0383
SYPL2 synaptophysin-like 2 1.02945
TNF tumor necrosis factor 1.01976
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.01385
CENPV centromere protein V 1.01343
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 1.0109
HLA-A major histocompatibility complex, class I, A 1.00077
CD69 CD69 molecule 0.97002
CD300C CD300c molecule 0.967083
CD40LG CD40 ligand 0.960797
NANP N-acetylneuraminic acid phosphatase 0.936629
MBP myelin basic protein 0.927105
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.920911
HTRA1 HtrA serine peptidase 1 0.920498
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.920085
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.919261
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.913903
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.912668
CD27 CD27 molecule 0.901156
LGMN legumain 0.895
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.891308
SV2A synaptic vesicle glycoprotein 2A 0.88393
IGHV3-30 immunoglobulin heavy variable 3-30 0.880243
CCR7 chemokine (C-C motif) receptor 7 0.879014
HLA-B major histocompatibility complex, class I, B 0.861818
IL1B interleukin 1, beta 0.861818
IL10 interleukin 10 0.860999
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.86018
CHAT choline O-acetyltransferase 0.852811
ERVW-1 endogenous retrovirus group W, member 1 0.833968
ICAM1 intercellular adhesion molecule 1 0.831918
CD276 CD276 molecule 0.824128
NPTXR neuronal pentraxin receptor 0.812232
BCHE butyrylcholinesterase 0.806077
STX1A syntaxin 1A (brain) 0.804846
DNAH8 dynein, axonemal, heavy chain 8 0.804026
LYZ lysozyme 0.800333
MNT MAX network transcriptional repressor 0.765127
VAMP8 vesicle-associated membrane protein 8 0.76431
SYT1 synaptotagmin I 0.755749
THY1 Thy-1 cell surface antigen 0.748424
TRAC T cell receptor alpha constant 0.736649
CD2 CD2 molecule 0.729762
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.729762
BDNF brain-derived neurotrophic factor 0.725311
TSPO translocator protein (18kDa) 0.716828
CD38 CD38 molecule 0.709572
CD300E CD300e molecule 0.707157
EPN1 epsin 1 0.703134
TG thyroglobulin 0.699517
SYP synaptophysin 0.693499
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.687091
PRPF18 pre-mRNA processing factor 18 0.678701
STX1B syntaxin 1B 0.672722
GLB1 galactosidase, beta 1 0.669936
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.663975
IGHV6-1 immunoglobulin heavy variable 6-1 0.656441
INS insulin 0.656046
SV2B synaptic vesicle glycoprotein 2B 0.653276
ACE2 angiotensin I converting enzyme 2 0.641827
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.639463
MYBPC1 myosin binding protein C, slow type 0.639463
PLCG1 phospholipase C, gamma 1 0.634349
RAB3A RAB3A, member RAS oncogene family 0.629242
FOXP3 forkhead box P3 0.622967
PCSK4 proprotein convertase subtilisin/kexin type 4 0.619442
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.617486
FN1 fibronectin 1 0.612401
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.608885
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.607323
IL2RA interleukin 2 receptor, alpha 0.597181
CPNE6 copine VI (neuronal) 0.594064
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.593674
TIMELESS timeless circadian clock 0.591337
CSN1S1 casein alpha s1 0.581606
TET1 tet methylcytosine dioxygenase 1 0.580439
SORBS3 sorbin and SH3 domain containing 3 0.579661
TOX thymocyte selection-associated high mobility group box 0.578494
IFNA1 interferon, alpha 1 0.577327
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.571495
C19ORF70 chromosome 19 open reading frame 70 0.568775
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.562169
SNHG12 small nucleolar RNA host gene 12 0.558674
TFRC transferrin receptor 0.555956
RHD Rh blood group, D antigen 0.555568
MYLK myosin light chain kinase 0.55518
IGHV3-9 immunoglobulin heavy variable 3-9 0.554015
HLA-C major histocompatibility complex, class I, C 0.552075
NCAM1 neural cell adhesion molecule 1 0.547419
ACHE acetylcholinesterase (Yt blood group) 0.546256
ATP11A ATPase, class VI, type 11A 0.54393
CD5 CD5 molecule 0.540055
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.535796
LTA lymphotoxin alpha 0.535409
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.532314
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.531928
TXN thioredoxin 0.529994
SYT7 synaptotagmin VII 0.52536
TFDP3 transcription factor Dp family, member 3 0.524588
MUC1 mucin 1, cell surface associated 0.522659
IL6 interleukin 6 0.518805
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.517265
LTB lymphotoxin beta (TNF superfamily, member 3) 0.515725
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.513802
AGFG1 ArfGAP with FG repeats 1 0.511496
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.511112
CD1B CD1b molecule 0.511112
TEPP testis, prostate and placenta expressed 0.507273
CTSE cathepsin E 0.506123
RHCE Rh blood group, CcEe antigens 0.499614
AHNAK AHNAK nucleoprotein 0.495793
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.491597
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.491597
HES5 hes family bHLH transcription factor 5 0.490072
TLR9 toll-like receptor 9 0.490072
MYLK2 myosin light chain kinase 2 0.485885
IL5 interleukin 5 0.484364
GRIP1 glutamate receptor interacting protein 1 0.482844
ICAM3 intercellular adhesion molecule 3 0.474877
DAZAP2 DAZ associated protein 2 0.472982
CCL28 chemokine (C-C motif) ligand 28 0.470332
TGFB1 transforming growth factor, beta 1 0.468063
GTPBP6 GTP binding protein 6 (putative) 0.465038
TNNT1 troponin T type 1 (skeletal, slow) 0.462016
GRM5 glutamate receptor, metabotropic 5 0.458619
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.458241
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.457487
SDC3 syndecan 3 0.448817
ADCY2 adenylate cyclase 2 (brain) 0.448441
TF transferrin 0.447311
SOS1 son of sevenless homolog 1 (Drosophila) 0.446558
SYT3 synaptotagmin III 0.446182
TDRD6 tudor domain containing 6 0.428516
FAM57A family with sequence similarity 57, member A 0.426265
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.425139
CTSS cathepsin S 0.424389
DPP4 dipeptidyl-peptidase 4 0.42139
FBXO3 F-box protein 3 0.421016
IL13 interleukin 13 0.419892
IL7R interleukin 7 receptor 0.416147
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.41596
ZFPM1 zinc finger protein, FOG family member 1 0.41465
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.41465
ADGRL2 adhesion G protein-coupled receptor L2 0.414276
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.412031
PRRC2A proline-rich coiled-coil 2A 0.411283
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.407919
GFAP glial fibrillary acidic protein 0.401572
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.398962
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.398962
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.398216
WDR11 WD repeat domain 11 0.397098
CFP complement factor properdin 0.39598
RBM15 RNA binding motif protein 15 0.395608
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.394863
CTF1 cardiotrophin 1 0.394118
NPR1 natriuretic peptide receptor 1 0.393001
GUCY2C guanylate cyclase 2C 0.391885
TLR4 toll-like receptor 4 0.390769
RRM1 ribonucleotide reductase M1 0.390769
CLDN11 claudin 11 0.390025
PRF1 perforin 1 (pore forming protein) 0.388166
GRM1 glutamate receptor, metabotropic 1 0.387423
RAB21 RAB21, member RAS oncogene family 0.386308
RYR1 ryanodine receptor 1 (skeletal) 0.386308
STMN2 stathmin 2 0.383708
CD34 CD34 molecule 0.380739
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.374438
ZNF185 zinc finger protein 185 (LIM domain) 0.371107
CCDC27 coiled-coil domain containing 27 0.368888
ICA1 islet cell autoantigen 1, 69kDa 0.368149
TLR2 toll-like receptor 2 0.366301
SPA17 sperm autoantigenic protein 17 0.363347
TCTEX1D4 Tctex1 domain containing 4 0.362978
CHRM5 cholinergic receptor, muscarinic 5 0.36187
MYO1G myosin IG 0.357446
RYR3 ryanodine receptor 3 0.357077
QDPR quinoid dihydropteridine reductase 0.352291
LATS1 large tumor suppressor kinase 1 0.35082
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.348981
C3 complement component 3 0.347879
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.342739
HEXA hexosaminidase A (alpha polypeptide) 0.341272
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.340173
SNAP25 synaptosomal-associated protein, 25kDa 0.337975
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.336876
CSN2 casein beta 0.336144
TGM1 transglutaminase 1 0.335778
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.326281
LPO lactoperoxidase 0.325552
PMEL premelanosome protein 0.323365
GDNF glial cell derived neurotrophic factor 0.320817
SOD1 superoxide dismutase 1, soluble 0.320454
C5AR1 complement component 5a receptor 1 0.32009
BICD1 bicaudal D homolog 1 (Drosophila) 0.317182
IL1A interleukin 1, alpha 0.315366
GML glycosylphosphatidylinositol anchored molecule like 0.314278
MAP1S microtubule-associated protein 1S 0.309928
PARP1 poly (ADP-ribose) polymerase 1 0.308842
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.307033
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.30631
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.304142
SGSM3 small G protein signaling modulator 3 0.300173
PDE4A phosphodiesterase 4A, cAMP-specific 0.298371
APOH apolipoprotein H (beta-2-glycoprotein I) 0.298371
PRDX5 peroxiredoxin 5 0.296211
NTS neurotensin 0.296211
NBAS neuroblastoma amplified sequence 0.292975
IGHV5-51 immunoglobulin heavy variable 5-51 0.291898
OXTR oxytocin receptor 0.290821
GPHN gephyrin 0.289744
IL7 interleukin 7 0.287235
CGA glycoprotein hormones, alpha polypeptide 0.284013
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.283655
TAC1 tachykinin, precursor 1 0.28151
SCD5 stearoyl-CoA desaturase 5 0.280439
CRLF1 cytokine receptor-like factor 1 0.277405
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.275801
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.272241
OPRM1 opioid receptor, mu 1 0.26993
CD300A CD300a molecule 0.268687
TMPO thymopoietin 0.268332
ERBB2 erb-b2 receptor tyrosine kinase 2 0.264077
CXCR3 chemokine (C-X-C motif) receptor 3 0.263722
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.263014
NGFR nerve growth factor receptor 0.261952
IFNG interferon, gamma 0.25877
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.258417
SP110 SP110 nuclear body protein 0.256652
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.256299
STX2 syntaxin 2 0.256299
CEMP1 cementum protein 1 0.250663
ASIP agouti signaling protein 0.250311
CIITA class II, major histocompatibility complex, transactivator 0.247501
CD1D CD1d molecule 0.246799
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.246098
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.245046
F2 coagulation factor II (thrombin) 0.245046
PRAMEF9 PRAME family member 9 0.241196
INA internexin neuronal intermediate filament protein, alpha 0.240847
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.238054
TAT tyrosine aminotransferase 0.237706
CETP cholesteryl ester transfer protein, plasma 0.237009
NPS neuropeptide S 0.236312
PLA2G1B phospholipase A2, group IB (pancreas) 0.234573
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 0.233183
GBP2 guanylate binding protein 2, interferon-inducible 0.228333
FYN FYN proto-oncogene, Src family tyrosine kinase 0.228333
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.226607
NRGN neurogranin (protein kinase C substrate, RC3) 0.226262
UNC13B unc-13 homolog B (C. elegans) 0.225229
ALPP alkaline phosphatase, placental 0.218715
FOS FBJ murine osteosarcoma viral oncogene homolog 0.218715
MRC1 mannose receptor, C type 1 0.218715
ZP4 zona pellucida glycoprotein 4 0.218374
CNR1 cannabinoid receptor 1 (brain) 0.218374
ADGRL1 adhesion G protein-coupled receptor L1 0.217352
TYR tyrosinase 0.217352
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.217012
AVPR2 arginine vasopressin receptor 2 0.216842
SST somatostatin 0.216332
MDH1 malate dehydrogenase 1, NAD (soluble) 0.215653
ACKR3 atypical chemokine receptor 3 0.213621
CASZ1 castor zinc finger 1 0.213621
HIAT1 hippocampus abundant transcript 1 0.213283
ADORA1 adenosine A1 receptor 0.212945
CTSD cathepsin D 0.209583
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.207245
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.206913
ENO2 enolase 2 (gamma, neuronal) 0.206913
SELL selectin L 0.206913
CXCL12 chemokine (C-X-C motif) ligand 12 0.204923
PTN pleiotrophin 0.203933
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.202618
TNNI2 troponin I type 2 (skeletal, fast) 0.200331
HMHA1 histocompatibility (minor) HA-1 0.199681
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.196139
CNTF ciliary neurotrophic factor 0.195979
MAP4 microtubule-associated protein 4 0.192971
UMOD uromodulin 0.192657
GLUL glutamate-ammonia ligase 0.191719
PRDM1 PR domain containing 1, with ZNF domain 0.190786
CD209 CD209 molecule 0.190476
ALPPL2 alkaline phosphatase, placental-like 2 0.188632
UNC13A unc-13 homolog A (C. elegans) 0.188326
LAG3 lymphocyte-activation gene 3 0.188022
RAB8A RAB8A, member RAS oncogene family 0.187719
ALPL alkaline phosphatase, liver/bone/kidney 0.187719
AKAP5 A kinase (PRKA) anchor protein 5 0.185612
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.182375
DEGS1 delta(4)-desaturase, sphingolipid 1 0.180084
NTF3 neurotrophin 3 0.179802
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.178682
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.178126
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.177851
IMMT inner membrane protein, mitochondrial 0.177301
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 0.177029
HSPA4 heat shock 70kDa protein 4 0.174093
TBX21 T-box 21 0.173571
PLP1 proteolipid protein 1 0.171785
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.170054
LPP LIM domain containing preferred translocation partner in lipoma 0.169091
ALCAM activated leukocyte cell adhesion molecule 0.168381
CD6 CD6 molecule 0.168381
C1S complement component 1, s subcomponent 0.167915
CD93 CD93 molecule 0.167915
B3GAT1 beta-1,3-glucuronyltransferase 1 0.166544
DES desmin 0.165874
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.164571
ZNF224 zinc finger protein 224 0.163523
SNAP91 synaptosomal-associated protein, 91kDa 0.161912
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.161523
MAP1B microtubule-associated protein 1B 0.161331
CD1C CD1c molecule 0.161139
LSM1 LSM1, U6 small nuclear RNA associated 0.161139
F9 coagulation factor IX 0.160948
GUSB glucuronidase, beta 0.160574
TSKU tsukushi, small leucine rich proteoglycan 0.15948
PER1 period circadian clock 1 0.14765