|Dataset||HPO Gene-Disease Associations|
|Category||disease or phenotype associations|
|Description||During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord. (Human Phenotype Ontology, HP_0002144)|
|Downloads & Tools|
4 genes associated with the tethered cord phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.