tetracycline-2080 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tetracycline-2080 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ADRBK1 adrenergic, beta, receptor kinase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATP11A ATPase, class VI, type 11A
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BMP4 bone morphogenetic protein 4
CHD1L chromodomain helicase DNA binding protein 1-like
CISH cytokine inducible SH2-containing protein
CNOT4 CCR4-NOT transcription complex, subunit 4
CREM cAMP responsive element modulator
CRYGD crystallin, gamma D
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP2 dual specificity phosphatase 2
EFNA3 ephrin-A3
EHD1 EH-domain containing 1
EPS8L1 EPS8-like 1
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FCMR Fc fragment of IgM receptor
FNBP1 formin binding protein 1
GLRB glycine receptor, beta
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLGA1 golgin A1
GOSR2 golgi SNAP receptor complex member 2
GPSM3 G-protein signaling modulator 3
HCRP1 hepatocellular carcinoma-related HCRP1
HHEX hematopoietically expressed homeobox
HOMER3 homer scaffolding protein 3
HOXA4 homeobox A4
HPS4 Hermansky-Pudlak syndrome 4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL27RA interleukin 27 receptor, alpha
IL32 interleukin 32
INHBA inhibin, beta A
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCTD14 potassium channel tetramerization domain containing 14
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM6A lysine (K)-specific demethylase 6A
KIFC3 kinesin family member C3
KRT17 keratin 17, type I
LAMP1 lysosomal-associated membrane protein 1
LINC00094 long intergenic non-protein coding RNA 94
LMAN1 lectin, mannose-binding, 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCL1 myeloid cell leukemia 1
MFN2 mitofusin 2
MTM1 myotubularin 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NADK NAD kinase
OXLD1 oxidoreductase-like domain containing 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCOLCE procollagen C-endopeptidase enhancer
PDS5A PDS5 cohesin associated factor A
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODNL1 podocan-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM19 RNA binding motif protein 19
RBMS2 RNA binding motif, single stranded interacting protein 2
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RTEL1 regulator of telomere elongation helicase 1
SCAPER S-phase cyclin A-associated protein in the ER
SCUBE3 signal peptide, CUB domain, EGF-like 3
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMAD5 SMAD family member 5
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX12 SRY (sex determining region Y)-box 12
STON1 stonin 1
TFEB transcription factor EB
TLN2 talin 2
TMEM120B transmembrane protein 120B
TRIM23 tripartite motif containing 23
TRIM29 tripartite motif containing 29
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USB1 U6 snRNA biogenesis 1
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR1 WD repeat domain 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF43 zinc finger protein 43
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACYP2 acylphosphatase 2, muscle type
AFAP1 actin filament associated protein 1
ALPK1 alpha-kinase 1
ANKRD40 ankyrin repeat domain 40
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BDNF brain-derived neurotrophic factor
BHLHE41 basic helix-loop-helix family, member e41
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C19ORF40 chromosome 19 open reading frame 40
C3ORF52 chromosome 3 open reading frame 52
C7ORF69 chromosome 7 open reading frame 69
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN15 calpain 15
CAPN5 calpain 5
CDA cytidine deaminase
CHST10 carbohydrate sulfotransferase 10
CINP cyclin-dependent kinase 2 interacting protein
CLCN5 chloride channel, voltage-sensitive 5
CNGB3 cyclic nucleotide gated channel beta 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CYC1 cytochrome c-1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
EFCAB2 EF-hand calcium binding domain 2
EGF epidermal growth factor
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM155A family with sequence similarity 155, member A
FBP1 fructose-1,6-bisphosphatase 1
FBXO2 F-box protein 2
FLCN folliculin
FXN frataxin
GPX4 glutathione peroxidase 4
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HMOX1 heme oxygenase 1
IL17RA interleukin 17 receptor A
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISL1 ISL LIM homeobox 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KDM7A lysine (K)-specific demethylase 7A
KIAA1549L KIAA1549-like
LINS lines homolog (Drosophila)
LYRM1 LYR motif containing 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MON1B MON1 secretory trafficking family member B
MSL2 male-specific lethal 2 homolog (Drosophila)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NCS1 neuronal calcium sensor 1
NGF nerve growth factor (beta polypeptide)
P3H2 prolyl 3-hydroxylase 2
PDGFRL platelet-derived growth factor receptor-like
PEX26 peroxisomal biogenesis factor 26
PISD phosphatidylserine decarboxylase
POLM polymerase (DNA directed), mu
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSKH1 protein serine kinase H1
PTK7 protein tyrosine kinase 7 (inactive)
RAB33B RAB33B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RBX1 ring-box 1, E3 ubiquitin protein ligase
RPS21 ribosomal protein S21
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SH2D2A SH2 domain containing 2A
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNHG20 small nucleolar RNA host gene 20
SNPH syntaphilin
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TESK1 testis-specific kinase 1
TLN1 talin 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPK1 thiamin pyrophosphokinase 1
TSKU tsukushi, small leucine rich proteoglycan
VASP vasodilator-stimulated phosphoprotein
VKORC1 vitamin K epoxide reductase complex, subunit 1
WNT5B wingless-type MMTV integration site family, member 5B
ZBTB3 zinc finger and BTB domain containing 3
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF394 zinc finger protein 394
ZNF574 zinc finger protein 574
ZNF8 zinc finger protein 8
ZNF804A zinc finger protein 804A