tetracycline-5757 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tetracycline-5757 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACAN aggrecan
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK2 aarF domain containing kinase 2
ADD2 adducin 2 (beta)
AFF1 AF4/FMR2 family, member 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARPIN actin-related protein 2/3 complex inhibitor
ARTN artemin
ATAD5 ATPase family, AAA domain containing 5
ATP9A ATPase, class II, type 9A
ATXN2L ataxin 2-like
C7ORF26 chromosome 7 open reading frame 26
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CDC25C cell division cycle 25C
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CREBZF CREB/ATF bZIP transcription factor
CRH corticotropin releasing hormone
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTN2 dynactin 2 (p50)
DGKA diacylglycerol kinase, alpha 80kDa
DZIP1 DAZ interacting zinc finger protein 1
EPS8L1 EPS8-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FRZB frizzled-related protein
GALR3 galanin receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR17 G protein-coupled receptor 17
GPR19 G protein-coupled receptor 19
HEMK1 HemK methyltransferase family member 1
HIC2 hypermethylated in cancer 2
HOOK1 hook microtubule-tethering protein 1
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
INO80D INO80 complex subunit D
ISYNA1 inositol-3-phosphate synthase 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KRT6A keratin 6A, type II
LAMA2 laminin, alpha 2
LGALS9 lectin, galactoside-binding, soluble, 9
LINC00472 long intergenic non-protein coding RNA 472
LOC100287590 uncharacterized LOC100287590
LOC399491
LPCAT4 lysophosphatidylcholine acyltransferase 4
MECOM MDS1 and EVI1 complex locus
MMP3 matrix metallopeptidase 3
MOBP myelin-associated oligodendrocyte basic protein
MRC2 mannose receptor, C type 2
MST1L macrophage stimulating 1-like
MTMR8 myotubularin related protein 8
NEK11 NIMA-related kinase 11
NFIB nuclear factor I/B
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
OTOR otoraplin
PAOX polyamine oxidase (exo-N4-amino)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDCD2 programmed cell death 2
PDE4A phosphodiesterase 4A, cAMP-specific
PHOX2A paired-like homeobox 2a
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRUNE2 prune homolog 2 (Drosophila)
RAB26 RAB26, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASAL2 RAS protein activator like 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RIMS3 regulating synaptic membrane exocytosis 3
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHOX2 short stature homeobox 2
SIRT4 sirtuin 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC25A30 solute carrier family 25, member 30
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMG7-AS1 SMG7 antisense RNA 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
TBX2 T-box 2
TPM1 tropomyosin 1 (alpha)
TSKS testis-specific serine kinase substrate
TUBB1 tubulin, beta 1 class VI
UPK1B uroplakin 1B
VAV1 vav 1 guanine nucleotide exchange factor
WTAP Wilms tumor 1 associated protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF549 zinc finger protein 549
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P1 annexin A2 pseudogene 1
ASIC3 acid sensing (proton gated) ion channel 3
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BAHD1 bromo adjacent homology domain containing 1
C11ORF30 chromosome 11 open reading frame 30
C16ORF59 chromosome 16 open reading frame 59
C1ORF159 chromosome 1 open reading frame 159
C1R complement component 1, r subcomponent
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CCNJL cyclin J-like
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP295 centrosomal protein 295kDa
CES3 carboxylesterase 3
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CISH cytokine inducible SH2-containing protein
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPA4 carboxypeptidase A4
CPED1 cadherin-like and PC-esterase domain containing 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DENND2D DENN/MADD domain containing 2D
DLL3 delta-like 3 (Drosophila)
DOK5 docking protein 5
DPF3 D4, zinc and double PHD fingers, family 3
DTX2 deltex 2, E3 ubiquitin ligase
EDAR ectodysplasin A receptor
EFNB1 ephrin-B1
EN2 engrailed homeobox 2
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
FGF13 fibroblast growth factor 13
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJC1 gap junction protein, gamma 1, 45kDa
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HIST1H2BC histone cluster 1, H2bc
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXA4 homeobox A4
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL12A interleukin 12A
IL15RA interleukin 15 receptor, alpha
IL20RA interleukin 20 receptor, alpha
IL4R interleukin 4 receptor
ITGA10 integrin, alpha 10
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
KIAA1462 KIAA1462
KLF3 Kruppel-like factor 3 (basic)
KLHL3 kelch-like family member 3
LIFR leukemia inhibitory factor receptor alpha
LIPG lipase, endothelial
LOC257152 uncharacterized LOC257152
LOC730101 uncharacterized LOC730101
LRRC6 leucine rich repeat containing 6
MAGEB2 melanoma antigen family B2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MRPL44 mitochondrial ribosomal protein L44
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NID2 nidogen 2 (osteonidogen)
NME5 NME/NM23 family member 5
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPM3 nucleophosmin/nucleoplasmin 3
ODF2 outer dense fiber of sperm tails 2
PRAMEF11 PRAME family member 11
PXMP4 peroxisomal membrane protein 4, 24kDa
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RWDD2A RWD domain containing 2A
SCN9A sodium channel, voltage gated, type IX alpha subunit
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETD1A SET domain containing 1A
SLC35F6 solute carrier family 35, member F6
SLC46A3 solute carrier family 46, member 3
STEAP4 STEAP family member 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNS2 tensin 2
UNC119 unc-119 homolog (C. elegans)
WFDC2 WAP four-disulfide core domain 2
ZFHX2 zinc finger homeobox 2
ZNF10 zinc finger protein 10
ZNF253 zinc finger protein 253
ZNF286A zinc finger protein 286A
ZNF573 zinc finger protein 573
ZNF668 zinc finger protein 668