tetrahydroalstonine-2748 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the tetrahydroalstonine-2748 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARTN artemin
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF12 chromosome 10 open reading frame 12
C1ORF56 chromosome 1 open reading frame 56
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC71 coiled-coil domain containing 71
CD34 CD34 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CTNS cystinosin, lysosomal cystine transporter
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNM1 dynamin 1
DOK2 docking protein 2, 56kDa
EDNRB endothelin receptor type B
ETAA1 Ewing tumor-associated antigen 1
ETV7 ets variant 7
FAM49B family with sequence similarity 49, member B
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS glutaminase
GMPR guanosine monophosphate reductase
GRPR gastrin-releasing peptide receptor
GSN gelsolin
HCRP1 hepatocellular carcinoma-related HCRP1
HDAC5 histone deacetylase 5
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER3 homer scaffolding protein 3
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
INHBE inhibin, beta E
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JADE2 jade family PHD finger 2
KCTD17 potassium channel tetramerization domain containing 17
KIAA1107 KIAA1107
LMCD1 LIM and cysteine-rich domains 1
LRRC14 leucine rich repeat containing 14
MAP4 microtubule-associated protein 4
MEGF6 multiple EGF-like-domains 6
MLANA melan-A
MMP11 matrix metallopeptidase 11
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NLRX1 NLR family member X1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD4 OTU deubiquitinase 4
PALM paralemmin
PGBD5 piggyBac transposable element derived 5
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PVT1 Pvt1 oncogene (non-protein coding)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHBG Rh family, B glycoprotein (gene/pseudogene)
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAG S-antigen; retina and pineal gland (arrestin)
SH3BP2 SH3-domain binding protein 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A44 solute carrier family 25, member 44
SLPI secretory leukocyte peptidase inhibitor
SNW1 SNW domain containing 1
SNX13 sorting nexin 13
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
STC1 stanniocalcin 1
STON1 stonin 1
TEX15 testis expressed 15
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
UBE3A ubiquitin protein ligase E3A
USB1 U6 snRNA biogenesis 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPR2 vasoactive intestinal peptide receptor 2
WNT16 wingless-type MMTV integration site family, member 16
YIPF2 Yip1 domain family, member 2
ZCCHC14 zinc finger, CCHC domain containing 14
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC14 zinc finger, DHHC-type containing 14
ZER1 zyg-11 related, cell cycle regulator
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF446 zinc finger protein 446
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ACTL8 actin-like 8
ADM adrenomedullin
AEN apoptosis enhancing nuclease
AHDC1 AT hook, DNA binding motif, containing 1
ALPK1 alpha-kinase 1
ARRB1 arrestin, beta 1
C11ORF30 chromosome 11 open reading frame 30
C4ORF29 chromosome 4 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CCNO cyclin O
CHKB choline kinase beta
CHPF chondroitin polymerizing factor
CLSPN claspin
CNR2 cannabinoid receptor 2 (macrophage)
COQ6 coenzyme Q6 monooxygenase
CRY2 cryptochrome circadian clock 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAL4 dynein, axonemal, light chain 4
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FAM212B family with sequence similarity 212, member B
FBRS fibrosin
FGGY FGGY carbohydrate kinase domain containing
FKBP5 FK506 binding protein 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HAUS2 HAUS augmin-like complex, subunit 2
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HMOX1 heme oxygenase 1
HPS6 Hermansky-Pudlak syndrome 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL22 interleukin 22
IQCG IQ motif containing G
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0894 KIAA0894 protein
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
LYRM9 LYR motif containing 9
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAMLD1 mastermind-like domain containing 1
MT1H metallothionein 1H
NCALD neurocalcin delta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NRGN neurogranin (protein kinase C substrate, RC3)
ONECUT2 one cut homeobox 2
PACS1 phosphofurin acidic cluster sorting protein 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHA6 protocadherin alpha 6
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
ROM1 retinal outer segment membrane protein 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCAI suppressor of cancer cell invasion
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD7 SMAD family member 7
SPRYD7 SPRY domain containing 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCTA T-cell leukemia translocation altered
TMEM121 transmembrane protein 121
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF2 TNF receptor-associated factor 2
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VASH2 vasohibin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEZT vezatin, adherens junctions transmembrane protein
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF652 zinc finger protein 652
ZNF862 zinc finger protein 862