tetrandrine-2520 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tetrandrine-2520 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADCK2 aarF domain containing kinase 2
AHNAK AHNAK nucleoprotein
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOXE3 arachidonate lipoxygenase 3
ANGPTL2 angiopoietin-like 2
APAF1 apoptotic peptidase activating factor 1
ATF7IP activating transcription factor 7 interacting protein
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BTF3 basic transcription factor 3
C17ORF53 chromosome 17 open reading frame 53
C19ORF73 chromosome 19 open reading frame 73
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3ORF18 chromosome 3 open reading frame 18
CCAR2 cell cycle and apoptosis regulator 2
CCSER2 coiled-coil serine-rich protein 2
CD200 CD200 molecule
CGA glycoprotein hormones, alpha polypeptide
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLEC3B C-type lectin domain family 3, member B
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DVL3 dishevelled segment polarity protein 3
DZIP3 DAZ interacting zinc finger protein 3
EML3 echinoderm microtubule associated protein like 3
ERP44 endoplasmic reticulum protein 44
FCAR Fc fragment of IgA receptor
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS6 growth arrest-specific 6
GEM GTP binding protein overexpressed in skeletal muscle
GHRHR growth hormone releasing hormone receptor
GMPR guanosine monophosphate reductase
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HDAC6 histone deacetylase 6
HEG1 heart development protein with EGF-like domains 1
HIC2 hypermethylated in cancer 2
HIPK3 homeodomain interacting protein kinase 3
HIST1H1B histone cluster 1, H1b
HIST1H3G histone cluster 1, H3g
HN1L hematological and neurological expressed 1-like
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
KIAA0485 uncharacterized LOC57235
KRIT1 KRIT1, ankyrin repeat containing
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTAP methylthioadenosine phosphorylase
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
PEG10 paternally expressed 10
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLSCR1 phospholipid scramblase 1
POFUT1 protein O-fucosyltransferase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP4R4 protein phosphatase 4, regulatory subunit 4
PPP5C protein phosphatase 5, catalytic subunit
PRAMEF11 PRAME family member 11
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCA protein kinase C, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
PVR poliovirus receptor
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
RNASE3 ribonuclease, RNase A family, 3
RND1 Rho family GTPase 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP7 ribosomal protein L23a pseudogene 7
SAFB2 scaffold attachment factor B2
SCAND2P SCAN domain containing 2 pseudogene
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC7 sialic acid binding Ig-like lectin 7
SIX2 SIX homeobox 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPHK1 sphingosine kinase 1
STS steroid sulfatase (microsomal), isozyme S
SYNJ1 synaptojanin 1
TAPBP TAP binding protein (tapasin)
TLR4 toll-like receptor 4
TMEM259 transmembrane protein 259
TP53I11 tumor protein p53 inducible protein 11
TSC2 tuberous sclerosis 2
UBE2B ubiquitin-conjugating enzyme E2B
UNC13A unc-13 homolog A (C. elegans)
VN1R1 vomeronasal 1 receptor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF205 zinc finger protein 205
ZNF446 zinc finger protein 446
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRE2 adhesion G protein-coupled receptor E2
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
AGBL5 ATP/GTP binding protein-like 5
AMT aminomethyltransferase
ANXA3 annexin A3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
BTBD7 BTB (POZ) domain containing 7
C7ORF69 chromosome 7 open reading frame 69
C9ORF114 chromosome 9 open reading frame 114
CAMKMT calmodulin-lysine N-methyltransferase
CDH10 cadherin 10, type 2 (T2-cadherin)
CDHR2 cadherin-related family member 2
CHML choroideremia-like (Rab escort protein 2)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC2D C-type lectin domain family 2, member D
COL19A1 collagen, type XIX, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DYM dymeclin
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FAM13C family with sequence similarity 13, member C
FBXL7 F-box and leucine-rich repeat protein 7
FGF23 fibroblast growth factor 23
FLJ21369 uncharacterized protein FLJ21369
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMPD1 FERM and PDZ domain containing 1
FZD2 frizzled class receptor 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GIPC1 GIPC PDZ domain containing family, member 1
GJA1 gap junction protein, alpha 1, 43kDa
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HAMP hepcidin antimicrobial peptide
HCG4 HLA complex group 4 (non-protein coding)
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFT140 intraflagellar transport 140
INO80D INO80 complex subunit D
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JMJD4 jumonji domain containing 4
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KIAA1456 KIAA1456
KPTN kaptin (actin binding protein)
KRT81 keratin 81, type II
LIMD2 LIM domain containing 2
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LPAR4 lysophosphatidic acid receptor 4
LTC4S leukotriene C4 synthase
MAGEF1 melanoma antigen family F1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
METTL2B methyltransferase like 2B
MOCS3 molybdenum cofactor synthesis 3
MON1B MON1 secretory trafficking family member B
MRAS muscle RAS oncogene homolog
MTMR12 myotubularin related protein 12
MTSS1L metastasis suppressor 1-like
MYO1E myosin IE
MYO5C myosin VC
NCS1 neuronal calcium sensor 1
NXF2 nuclear RNA export factor 2
PLA2G15 phospholipase A2, group XV
PRAF2 PRA1 domain family, member 2
RAB13 RAB13, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
RNF39 ring finger protein 39
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC16A6 solute carrier family 16, member 6
SLC38A6 solute carrier family 38, member 6
SPATA2L spermatogenesis associated 2-like
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STBD1 starch binding domain 1
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TCTA T-cell leukemia translocation altered
TESPA1 thymocyte expressed, positive selection associated 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM212 transmembrane protein 212
TNS2 tensin 2
TTLL1 tubulin tyrosine ligase-like family member 1
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
YY2 YY2 transcription factor
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF10 zinc finger protein 10
ZNF480 zinc finger protein 480
ZNF747 zinc finger protein 747
ZSCAN31 zinc finger and SCAN domain containing 31