tetroquinone-4078 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tetroquinone-4078 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCK2 aarF domain containing kinase 2
ADGRA2 adhesion G protein-coupled receptor A2
APOC4 apolipoprotein C-IV
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASCL1 achaete-scute family bHLH transcription factor 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCHE butyrylcholinesterase
CA1 carbonic anhydrase I
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CAMP cathelicidin antimicrobial peptide
CAPN9 calpain 9
CASP8 caspase 8, apoptosis-related cysteine peptidase
CIITA class II, major histocompatibility complex, transactivator
COL21A1 collagen, type XXI, alpha 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGKA diacylglycerol kinase, alpha 80kDa
DPF1 D4, zinc and double PHD fingers family 1
DSCC1 DNA replication and sister chromatid cohesion 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
FGA fibrinogen alpha chain
FGF4 fibroblast growth factor 4
FKBP10 FK506 binding protein 10, 65 kDa
FSCN3 fascin actin-bundling protein 3, testicular
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GH1 growth hormone 1
GIF gastric intrinsic factor (vitamin B synthesis)
GLB1L galactosidase, beta 1-like
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HHLA1 HERV-H LTR-associating 1
HIST3H3 histone cluster 3, H3
HOXC11 homeobox C11
HRASLS2 HRAS-like suppressor 2
IFT27 intraflagellar transport 27
INHBC inhibin, beta C
IRX5 iroquois homeobox 5
IZUMO4 IZUMO family member 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDSR 3-ketodihydrosphingosine reductase
KMT2A lysine (K)-specific methyltransferase 2A
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK11 mitogen-activated protein kinase 11
MIER2 mesoderm induction early response 1, family member 2
MST1 macrophage stimulating 1
MTMR3 myotubularin related protein 3
MYO1B myosin IB
NPY2R neuropeptide Y receptor Y2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTNG1 netrin G1
OGFR opioid growth factor receptor
OSGIN2 oxidative stress induced growth inhibitor family member 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBX1 pre-B-cell leukemia homeobox 1
PCDHGA1 protocadherin gamma subfamily A, 1
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGLYRP1 peptidoglycan recognition protein 1
PHF7 PHD finger protein 7
PICK1 protein interacting with PRKCA 1
PNLIPRP2 pancreatic lipase-related protein 2
PPARD peroxisome proliferator-activated receptor delta
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKCA protein kinase C, alpha
PSG11 pregnancy specific beta-1-glycoprotein 11
RAB33A RAB33A, member RAS oncogene family
RB1 retinoblastoma 1
RECQL5 RecQ protein-like 5
RGS6 regulator of G-protein signaling 6
RIMS1 regulating synaptic membrane exocytosis 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A9 solute carrier family 39, member 9
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMO smoothened, frizzled class receptor
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOS2 son of sevenless homolog 2 (Drosophila)
SPAG6 sperm associated antigen 6
SPRED2 sprouty-related, EVH1 domain containing 2
SRSF5 serine/arginine-rich splicing factor 5
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFCP2L1 transcription factor CP2-like 1
TXK TXK tyrosine kinase
ZNF516 zinc finger protein 516

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACE angiotensin I converting enzyme
AFAP1 actin filament associated protein 1
AGO4 argonaute RISC catalytic component 4
ALPK1 alpha-kinase 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARMCX4 armadillo repeat containing, X-linked 4
ARR3 arrestin 3, retinal (X-arrestin)
ASTN1 astrotactin 1
BAGE B melanoma antigen
BMP10 bone morphogenetic protein 10
BTC betacellulin
BTF3P11 basic transcription factor 3 pseudogene 11
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF105 chromosome 1 open reading frame 105
C4ORF29 chromosome 4 open reading frame 29
CA11 carbonic anhydrase XI
CAMKMT calmodulin-lysine N-methyltransferase
CAPN15 calpain 15
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CD68 CD68 molecule
CFAP45 cilia and flagella associated protein 45
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN1 claudin 1
CLIC3 chloride intracellular channel 3
CNN1 calponin 1, basic, smooth muscle
CPPED1 calcineurin-like phosphoesterase domain containing 1
DNM3 dynamin 3
DTX2 deltex 2, E3 ubiquitin ligase
ERO1LB ERO1-like beta (S. cerevisiae)
EVPL envoplakin
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM184A family with sequence similarity 184, member A
FBXO2 F-box protein 2
FBXO22 F-box protein 22
FGL1 fibrinogen-like 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMPR guanosine monophosphate reductase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HHAT hedgehog acyltransferase
HIST1H3F histone cluster 1, H3f
HOXA4 homeobox A4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
INF2 inverted formin, FH2 and WH2 domain containing
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRT86 keratin 86, type II
LIME1 Lck interacting transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
LRP3 low density lipoprotein receptor-related protein 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LUM lumican
MAP3K7CL MAP3K7 C-terminal like
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD12 major facilitator superfamily domain containing 12
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
MYL5 myosin, light chain 5, regulatory
MYO1D myosin ID
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NPVF neuropeptide VF precursor
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDH12 protocadherin 12
PCDHGA10 protocadherin gamma subfamily A, 10
POMT2 protein-O-mannosyltransferase 2
RAB27B RAB27B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RPGR retinitis pigmentosa GTPase regulator
RPL23AP32 ribosomal protein L23a pseudogene 32
SELL selectin L
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STEAP4 STEAP family member 4
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
THBS3 thrombospondin 3
THRB thyroid hormone receptor, beta
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF2 TNF receptor-associated factor 2
TUBA4B tubulin, alpha 4b
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
ZNF426 zinc finger protein 426
ZNF549 zinc finger protein 549