tgfbr2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description transforming growth factor, beta receptor II (70/80kDa)|This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7048)
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Genes

24 genes co-occuring with the biological term tgfbr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR2A activin A receptor, type IIA
ACVRL1 activin A receptor type II-like 1
AR androgen receptor
ASTE1 asteroid homolog 1 (Drosophila)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
FBN1 fibrillin 1
IGFBP3 insulin-like growth factor binding protein 3
IQGAP1 IQ motif containing GTPase activating protein 1
MIR106A microRNA 106a
MIR20A microRNA 20a
MIR21 microRNA 21
MIR655 microRNA 655
MIR93 microRNA 93
PTH1R parathyroid hormone 1 receptor
SPP1 secreted phosphoprotein 1
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZEB1 zinc finger E-box binding homeobox 1