thalidomide-5990 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the thalidomide-5990 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AHI1 Abelson helper integration site 1
AK1 adenylate kinase 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARSD arylsulfatase D
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B9D1 B9 protein domain 1
BMP1 bone morphogenetic protein 1
C14ORF1 chromosome 14 open reading frame 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CARD14 caspase recruitment domain family, member 14
CCL13 chemokine (C-C motif) ligand 13
CD79B CD79b molecule, immunoglobulin-associated beta
CDC42 cell division cycle 42
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCN decorin
DEPDC5 DEP domain containing 5
DLC1 DLC1 Rho GTPase activating protein
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DPF1 D4, zinc and double PHD fingers family 1
DRICH1 aspartate-rich 1
DSC2 desmocollin 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETNK2 ethanolamine kinase 2
EXOSC2 exosome component 2
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM155A family with sequence similarity 155, member A
FAM214B family with sequence similarity 214, member B
FRMD8 FERM domain containing 8
GAB1 GRB2-associated binding protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR135 G protein-coupled receptor 135
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HPCAL4 hippocalcin like 4
ING4 inhibitor of growth family, member 4
JAM3 junctional adhesion molecule 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LAMC2 laminin, gamma 2
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LINC00302 long intergenic non-protein coding RNA 302
LOC644450 uncharacterized LOC644450
LOC79999 uncharacterized LOC79999
LRRC6 leucine rich repeat containing 6
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK7 mitogen-activated protein kinase 7
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP3 matrix metallopeptidase 3
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTMR3 myotubularin related protein 3
MTMR7 myotubularin related protein 7
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUDCD3 NudC domain containing 3
ORM1 orosomucoid 1
PAX2 paired box 2
PCDHB12 protocadherin beta 12
PCDHB13 protocadherin beta 13
PDLIM3 PDZ and LIM domain 3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PML promyelocytic leukemia
PQLC2 PQ loop repeat containing 2
PRR5 proline rich 5 (renal)
PTAFR platelet-activating factor receptor
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB40C RAB40C, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RGCC regulator of cell cycle
RNF122 ring finger protein 122
SBF1 SET binding factor 1
SECTM1 secreted and transmembrane 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPB surfactant protein B
SNN stannin
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SP100 SP100 nuclear antigen
STAB2 stabilin 2
SUGP1 SURP and G patch domain containing 1
TBC1D2 TBC1 domain family, member 2
TJAP1 tight junction associated protein 1 (peripheral)
TPMT thiopurine S-methyltransferase
TRIM21 tripartite motif containing 21
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
UHRF1BP1L UHRF1 binding protein 1-like
USB1 U6 snRNA biogenesis 1
VNN1 vanin 1
XAB2 XPA binding protein 2
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRG2 adhesion G protein-coupled receptor G2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C5 complement component 5
CALCOCO1 calcium binding and coiled-coil domain 1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHML choroideremia-like (Rab escort protein 2)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN15 claudin 15
CRIP1 cysteine-rich protein 1 (intestinal)
CUL9 cullin 9
CXORF56 chromosome X open reading frame 56
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFHD2 EF-hand domain family, member D2
EFNA3 ephrin-A3
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM169A family with sequence similarity 169, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FLCN folliculin
FLRT3 fibronectin leucine rich transmembrane protein 3
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GMPR guanosine monophosphate reductase
GPALPP1 GPALPP motifs containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H4D histone cluster 1, H4d
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL17RA interleukin 17 receptor A
INCENP inner centromere protein antigens 135/155kDa
IQSEC2 IQ motif and Sec7 domain 2
IRF9 interferon regulatory factor 9
IRX4 iroquois homeobox 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLF3 Kruppel-like factor 3 (basic)
KLF7 Kruppel-like factor 7 (ubiquitous)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC20 leucine rich repeat containing 20
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP1S microtubule-associated protein 1S
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
METTL2B methyltransferase like 2B
MFAP2 microfibrillar-associated protein 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NCS1 neuronal calcium sensor 1
NMRK1 nicotinamide riboside kinase 1
PDE8B phosphodiesterase 8B
PHC1 polyhomeotic homolog 1 (Drosophila)
PITX2 paired-like homeodomain 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PQLC1 PQ loop repeat containing 1
PRODH proline dehydrogenase (oxidase) 1
PROS1 protein S (alpha)
RCAN3 RCAN family member 3
RNF31 ring finger protein 31
RPGR retinitis pigmentosa GTPase regulator
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SOWAHC sosondowah ankyrin repeat domain family member C
SP1 Sp1 transcription factor
SUSD4 sushi domain containing 4
TDRD1 tudor domain containing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS3 thrombospondin 3
TLN1 talin 1
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TRAF5 TNF receptor-associated factor 5
TRIM52 tripartite motif containing 52
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
WFDC2 WAP four-disulfide core domain 2
ZBED1 zinc finger, BED-type containing 1
ZBTB39 zinc finger and BTB domain containing 39
ZFP37 ZFP37 zinc finger protein
ZNF136 zinc finger protein 136
ZNF480 zinc finger protein 480
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZNF813 zinc finger protein 813