thapsigargin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. (Chemical Entities of Biological Interest Ontology, CHEBI_9516)
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Genes

21 genes co-occuring with the biological term thapsigargin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBC3 BCL2 binding component 3
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
EGF epidermal growth factor
F2RL1 coagulation factor II (thrombin) receptor-like 1
GSK3B glycogen synthase kinase 3 beta
LMAN1 lectin, mannose-binding, 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G5 phospholipase A2, group V
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
STIM1 stromal interaction molecule 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3