theobromine-2995 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the theobromine-2995 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANG angiogenin, ribonuclease, RNase A family, 5
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP35 Rho GTPase activating protein 35
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATXN2L ataxin 2-like
BAGE B melanoma antigen
BCAS1 breast carcinoma amplified sequence 1
BCAS3 breast carcinoma amplified sequence 3
C21ORF2 chromosome 21 open reading frame 2
C9ORF9 chromosome 9 open reading frame 9
CALD1 caldesmon 1
CCSER2 coiled-coil serine-rich protein 2
CD1E CD1e molecule
CD300C CD300c molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEMP1 cementum protein 1
CHMP6 charged multivesicular body protein 6
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
DSTYK dual serine/threonine and tyrosine protein kinase
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DZIP3 DAZ interacting zinc finger protein 3
EFNB3 ephrin-B3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF1 eukaryotic translation initiation factor 1
EMILIN2 elastin microfibril interfacer 2
ESR2 estrogen receptor 2 (ER beta)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FDPS farnesyl diphosphate synthase
GABARAPL1 GABA(A) receptor-associated protein like 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GP5 glycoprotein V (platelet)
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSG1 germ cell associated 1
GSPT1 G1 to S phase transition 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC6 histone deacetylase 6
HIST1H2BC histone cluster 1, H2bc
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1R2 interleukin 1 receptor, type II
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAM2 junctional adhesion molecule 2
KDSR 3-ketodihydrosphingosine reductase
KHK ketohexokinase (fructokinase)
KLC2 kinesin light chain 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRTAP2-4 keratin associated protein 2-4
LAMA2 laminin, alpha 2
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LIMS2 LIM and senescent cell antigen-like domains 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAP2K7 mitogen-activated protein kinase kinase 7
MED14 mediator complex subunit 14
MMP3 matrix metallopeptidase 3
MRPS12 mitochondrial ribosomal protein S12
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYOZ3 myozenin 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMT2 N-myristoyltransferase 2
NRG2 neuregulin 2
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PBX2 pre-B-cell leukemia homeobox 2
PIGR polymeric immunoglobulin receptor
PKP1 plakophilin 1
PLCL2 phospholipase C-like 2
PNPLA4 patatin-like phospholipase domain containing 4
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PVR poliovirus receptor
PXDC1 PX domain containing 1
RASAL2 RAS protein activator like 2
RBPMS RNA binding protein with multiple splicing
RPL3L ribosomal protein L3-like
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SMAD5 SMAD family member 5
SOCS2 suppressor of cytokine signaling 2
SPHK2 sphingosine kinase 2
SSBP2 single-stranded DNA binding protein 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STK3 serine/threonine kinase 3
TBX5 T-box 5
TMEM242 transmembrane protein 242
TRPS1 trichorhinophalangeal syndrome I
TSPAN2 tetraspanin 2
TUBA4B tubulin, alpha 4b
WDR59 WD repeat domain 59
WISP3 WNT1 inducible signaling pathway protein 3
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YOD1 YOD1 deubiquitinase
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ANO2 anoctamin 2, calcium activated chloride channel
ANXA2P3 annexin A2 pseudogene 3
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
AVPI1 arginine vasopressin-induced 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BTF3P11 basic transcription factor 3 pseudogene 11
C7ORF69 chromosome 7 open reading frame 69
CCDC85C coiled-coil domain containing 85C
CD79B CD79b molecule, immunoglobulin-associated beta
CD9 CD9 molecule
CDK20 cyclin-dependent kinase 20
CELP carboxyl ester lipase pseudogene
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLDN3 claudin 3
CLGN calmegin
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CYSLTR1 cysteinyl leukotriene receptor 1
DAGLA diacylglycerol lipase, alpha
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM106A family with sequence similarity 106, member A
FGF23 fibroblast growth factor 23
FKBPL FK506 binding protein like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS3 fibroblast growth factor receptor substrate 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLRA1 glycine receptor, alpha 1
GPC3 glypican 3
HHLA3 HERV-H LTR-associating 3
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA2 homeobox A2
HOXA6 homeobox A6
HOXB9 homeobox B9
HOXC10 homeobox C10
HOXC8 homeobox C8
IBSP integrin-binding sialoprotein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT140 intraflagellar transport 140
IGH immunoglobulin heavy locus
IRF7 interferon regulatory factor 7
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KRT12 keratin 12, type I
KRT20 keratin 20, type I
KRT81 keratin 81, type II
LIME1 Lck interacting transmembrane adaptor 1
LRP5 low density lipoprotein receptor-related protein 5
LTC4S leukotriene C4 synthase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED15 mediator complex subunit 15
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NAT6 N-acetyltransferase 6 (GCN5-related)
NCS1 neuronal calcium sensor 1
NLGN1 neuroligin 1
NMUR1 neuromedin U receptor 1
NT5DC3 5'-nucleotidase domain containing 3
OSBP2 oxysterol binding protein 2
PADI2 peptidyl arginine deiminase, type II
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBOV1 prostate and breast cancer overexpressed 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAT plasminogen activator, tissue
PMFBP1 polyamine modulated factor 1 binding protein 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRO2964 uncharacterized protein PRO2964
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM12B-AS1 RBM12B antisense RNA 1
RPL13P5 ribosomal protein L13 pseudogene 5
SCRT1 scratch family zinc finger 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERINC5 serine incorporator 5
SFRP5 secreted frizzled-related protein 5
SH3GLB2 SH3-domain GRB2-like endophilin B2
SKA1 spindle and kinetochore associated complex subunit 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC16A6 solute carrier family 16, member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMAD7 SMAD family member 7
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SYTL2 synaptotagmin-like 2
TAS2R10 taste receptor, type 2, member 10
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM140 transmembrane protein 140
TOM1 target of myb1 (chicken)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
ZNF282 zinc finger protein 282
ZNF385D zinc finger protein 385D