theophylline-3326 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the theophylline-3326 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APOLD1 apolipoprotein L domain containing 1
ARHGAP26 Rho GTPase activating protein 26
ARID1A AT rich interactive domain 1A (SWI-like)
BCORL1 BCL6 corepressor-like 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALB1 calbindin 1, 28kDa
CCL27 chemokine (C-C motif) ligand 27
CCL7 chemokine (C-C motif) ligand 7
CD6 CD6 molecule
CDRT1 CMT1A duplicated region transcript 1
CEP295 centrosomal protein 295kDa
CRH corticotropin releasing hormone
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DRD2 dopamine receptor D2
ELL elongation factor RNA polymerase II
ELL2 elongation factor, RNA polymerase II, 2
F5 coagulation factor V (proaccelerin, labile factor)
FBXO21 F-box protein 21
FBXO40 F-box protein 40
FBXO41 F-box protein 41
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
HAND1 heart and neural crest derivatives expressed 1
HFE hemochromatosis
HIST1H2BE histone cluster 1, H2be
HOXA6 homeobox A6
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL17RC interleukin 17 receptor C
IL1R2 interleukin 1 receptor, type II
IL2RG interleukin 2 receptor, gamma
INO80D INO80 complex subunit D
ITGA9 integrin, alpha 9
JAG1 jagged 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KITLG KIT ligand
KLHDC8A kelch domain containing 8A
LGALS9 lectin, galactoside-binding, soluble, 9
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDN necdin, melanoma antigen (MAGE) family member
NEUROD4 neuronal differentiation 4
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PARD6B par-6 family cell polarity regulator beta
PARG poly (ADP-ribose) glycohydrolase
PCDH1 protocadherin 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM4 PDZ and LIM domain 4
PHF20L1 PHD finger protein 20-like 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PODNL1 podocan-like 1
POMT2 protein-O-mannosyltransferase 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRB3 proline-rich protein BstNI subfamily 3
PRKCI protein kinase C, iota
PRLR prolactin receptor
PVR poliovirus receptor
PVRL3 poliovirus receptor-related 3
RGS10 regulator of G-protein signaling 10
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL10 ribosomal protein L10
RUFY3 RUN and FYVE domain containing 3
RUNDC3A RUN domain containing 3A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC39A9 solute carrier family 39, member 9
SPAG8 sperm associated antigen 8
SUGP1 SURP and G patch domain containing 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYT2 synaptotagmin II
TAOK2 TAO kinase 2
TBL2 transducin (beta)-like 2
TEX40 testis expressed 40
TMPRSS15 transmembrane protease, serine 15
TSPAN2 tetraspanin 2
TYRO3 TYRO3 protein tyrosine kinase
UBA7 ubiquitin-like modifier activating enzyme 7
UPK3A uroplakin 3A
USH1C Usher syndrome 1C (autosomal recessive, severe)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB33 zinc finger and BTB domain containing 33
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76
ZSCAN12 zinc finger and SCAN domain containing 12
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
AKIP1 A kinase (PRKA) interacting protein 1
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARL15 ADP-ribosylation factor-like 15
ASIC3 acid sensing (proton gated) ion channel 3
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAHD1 bromo adjacent homology domain containing 1
BRD9 bromodomain containing 9
BTBD2 BTB (POZ) domain containing 2
C1ORF105 chromosome 1 open reading frame 105
CA4 carbonic anhydrase IV
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCP110 centriolar coiled coil protein 110kDa
CORO7 coronin 7
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF4 DDB1 and CUL4 associated factor 4
DSCAM Down syndrome cell adhesion molecule
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO22 F-box protein 22
FER fer (fps/fes related) tyrosine kinase
GEMIN8 gem (nuclear organelle) associated protein 8
GFI1 growth factor independent 1 transcription repressor
GLB1L galactosidase, beta 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRAMD1C GRAM domain containing 1C
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HYI hydroxypyruvate isomerase (putative)
IL22 interleukin 22
IQSEC2 IQ motif and Sec7 domain 2
IRF1 interferon regulatory factor 1
IRF9 interferon regulatory factor 9
JMJD4 jumonji domain containing 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KAT2A K(lysine) acetyltransferase 2A
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA1107 KIAA1107
LHX1 LIM homeobox 1
LRP3 low density lipoprotein receptor-related protein 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP1S microtubule-associated protein 1S
MFAP2 microfibrillar-associated protein 2
MOCS3 molybdenum cofactor synthesis 3
MTCP1 mature T-cell proliferation 1
MTMR6 myotubularin related protein 6
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
NPIPB15 nuclear pore complex interacting protein family, member B15
NPTX1 neuronal pentraxin I
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB13 protocadherin beta 13
PCDHGB5 protocadherin gamma subfamily B, 5
PGPEP1 pyroglutamyl-peptidase I
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRODH proline dehydrogenase (oxidase) 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNF170 ring finger protein 170
RPL10L ribosomal protein L10-like
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SP1 Sp1 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STIM1 stromal interaction molecule 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D2 TBC1 domain family, member 2
TET3 tet methylcytosine dioxygenase 3
THRB thyroid hormone receptor, beta
TMEM121 transmembrane protein 121
TNRC6B trinucleotide repeat containing 6B
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VASH2 vasohibin 2
VPS9D1 VPS9 domain containing 1
XDH xanthine dehydrogenase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H12A zinc finger CCCH-type containing 12A
ZNF10 zinc finger protein 10
ZNF350 zinc finger protein 350
ZNF492 zinc finger protein 492