therapeutic Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

336 proteins co-occuring with the biological term therapeutic in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
ADAM17 ADAM metallopeptidase domain 17
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
APP amyloid beta (A4) precursor protein
APTX aprataxin
AQP4 aquaporin 4
AQP5 aquaporin 5
AR androgen receptor
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATXN1 ataxin 1
AURKA aurora kinase A
AURKB aurora kinase B
AXIN1 axin 1
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BANP BTG3 associated nuclear protein
BCAR1 breast cancer anti-estrogen resistance 1
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
BMX BMX non-receptor tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
C1QBP complement component 1, q subcomponent binding protein
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALY calcyon neuron-specific vesicular protein
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARD11 caspase recruitment domain family, member 11
CARD9 caspase recruitment domain family, member 9
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC6 coiled-coil domain containing 6
CCDC88A coiled-coil domain containing 88A
CCKBR cholecystokinin B receptor
CCND1 cyclin D1
CD28 CD28 molecule
CDC25C cell division cycle 25C
CDCA8 cell division cycle associated 8
CDCP1 CUB domain containing protein 1
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF1 CUGBP, Elav-like family member 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CIB1 calcium and integrin binding 1 (calmyrin)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COPS6 COP9 signalosome subunit 6
CREB1 cAMP responsive element binding protein 1
CRTC2 CREB regulated transcription coactivator 2
CRYAB crystallin, alpha B
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CUX1 cut-like homeobox 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYSLTR1 cysteinyl leukotriene receptor 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEPTOR DEP domain containing MTOR-interacting protein
DISC1 disrupted in schizophrenia 1
DLG4 discs, large homolog 4 (Drosophila)
DNM2 dynamin 2
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DOCK1 dedicator of cytokinesis 1
DUT deoxyuridine triphosphatase
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
EPHA3 EPH receptor A3
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FBXL2 F-box and leucine-rich repeat protein 2
FGFR1 fibroblast growth factor receptor 1
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GCM1 glial cells missing homolog 1 (Drosophila)
GJA1 gap junction protein, alpha 1, 43kDa
GLI1 GLI family zinc finger 1
GLRA3 glycine receptor, alpha 3
GLUL glutamate-ammonia ligase
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPHN gephyrin
GRB7 growth factor receptor-bound protein 7
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
HAVCR2 hepatitis A virus cellular receptor 2
HDAC5 histone deacetylase 5
HIST1H3A histone cluster 1, H3a
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTT huntingtin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL6ST interleukin 6 signal transducer
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
ISYNA1 inositol-3-phosphate synthase 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JUN jun proto-oncogene
KAT7 K(lysine) acetyltransferase 7
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
KLF5 Kruppel-like factor 5 (intestinal)
KRT18 keratin 18, type I
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LRP6 low density lipoprotein receptor-related protein 6
LRRK2 leucine-rich repeat kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAF1 MAF1 homolog (S. cerevisiae)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MCTS1 malignant T cell amplified sequence 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MPZL1 myelin protein zero-like 1
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NDRG1 N-myc downstream regulated 1
NEK6 NIMA-related kinase 6
NF2 neurofibromin 2 (merlin)
NFE2L1 nuclear factor, erythroid 2-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCLN occludin
ORC2 origin recognition complex, subunit 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARK2 parkin RBR E3 ubiquitin protein ligase
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEAK1 pseudopodium-enriched atypical kinase 1
PFN1 profilin 1
PGR progesterone receptor
PHB2 prohibitin 2
PINK1 PTEN induced putative kinase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PML promyelocytic leukemia
PNPLA8 patatin-like phospholipase domain containing 8
POLH polymerase (DNA directed), eta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRA protein tyrosine phosphatase, receptor type, A
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXN paxillin
RAD52 RAD52 homolog (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RGS18 regulator of G-protein signaling 18
RORA RAR-related orphan receptor A
RPA2 replication protein A2, 32kDa
RPL13A ribosomal protein L13a
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLK STE20-like kinase
SMAD2 SMAD family member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNAPIN SNAP-associated protein
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SSTR2 somatostatin receptor 2
SSTR5 somatostatin receptor 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK11 serine/threonine kinase 11
STMN1 stathmin 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SYK spleen tyrosine kinase
SYN1 synapsin I
TACC3 transforming, acidic coiled-coil containing protein 3
TARDBP TAR DNA binding protein
TCP1 t-complex 1
TEK TEK tyrosine kinase, endothelial
TH tyrosine hydroxylase
TNK2 tyrosine kinase, non-receptor, 2
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSC2 tuberous sclerosis 2
TTK TTK protein kinase
TWIST1 twist family bHLH transcription factor 1
VASP vasodilator-stimulated phosphoprotein
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF148 zinc finger protein 148