thioproperazine-5791 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the thioproperazine-5791 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTN2 actinin, alpha 2
ADAMDEC1 ADAM-like, decysin 1
AGFG2 ArfGAP with FG repeats 2
AKAP5 A kinase (PRKA) anchor protein 5
ALOX5 arachidonate 5-lipoxygenase
ALOXE3 arachidonate lipoxygenase 3
APOE apolipoprotein E
APOF apolipoprotein F
ARID5A AT rich interactive domain 5A (MRF1-like)
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF7IP activating transcription factor 7 interacting protein
ATXN2L ataxin 2-like
BBC3 BCL2 binding component 3
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BMP7 bone morphogenetic protein 7
C1QL1 complement component 1, q subcomponent-like 1
C2ORF27A chromosome 2 open reading frame 27A
CCDC28B coiled-coil domain containing 28B
CCNO cyclin O
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPA3 carboxypeptidase A3 (mast cell)
CPNE7 copine VII
CRHR2 corticotropin releasing hormone receptor 2
CTSZ cathepsin Z
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DFNB31 deafness, autosomal recessive 31
DHRS12 dehydrogenase/reductase (SDR family) member 12
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FBXO2 F-box protein 2
FOXF1 forkhead box F1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR85 G protein-coupled receptor 85
GPRC5D G protein-coupled receptor, class C, group 5, member D
HIST1H2BM histone cluster 1, H2bm
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
INSIG1 insulin induced gene 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUND jun D proto-oncogene
KCNIP1 Kv channel interacting protein 1
KIAA0391 KIAA0391
KIAA1456 KIAA1456
KIF1C kinesin family member 1C
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
LDAH lipid droplet associated hydrolase
MAP3K7CL MAP3K7 C-terminal like
MCF2L MCF.2 cell line derived transforming sequence-like
MEOX1 mesenchyme homeobox 1
MFAP3 microfibrillar-associated protein 3
MMP25 matrix metallopeptidase 25
MST1 macrophage stimulating 1
MTRF1L mitochondrial translational release factor 1-like
MYRF myelin regulatory factor
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NAV3 neuron navigator 3
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME5 NME/NM23 family member 5
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR2W1 olfactory receptor, family 2, subfamily W, member 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIDD1 p53-induced death domain protein 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POU3F1 POU class 3 homeobox 1
POU3F4 POU class 3 homeobox 4
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PSD4 pleckstrin and Sec7 domain containing 4
PTPRR protein tyrosine phosphatase, receptor type, R
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB27B RAB27B, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RHO rhodopsin
RIMS3 regulating synaptic membrane exocytosis 3
RPL18 ribosomal protein L18
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SBNO2 strawberry notch homolog 2 (Drosophila)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SIRPB1 signal-regulatory protein beta 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPN sialophorin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TYMS thymidylate synthetase
USP29 ubiquitin specific peptidase 29
ZC3H7B zinc finger CCCH-type containing 7B
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF224 zinc finger protein 224
ZNF639 zinc finger protein 639
ZP2 zona pellucida glycoprotein 2 (sperm receptor)

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP10 Rho GTPase activating protein 10
ART1 ADP-ribosyltransferase 1
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
BAK1 BCL2-antagonist/killer 1
BICC1 BicC family RNA binding protein 1
BTBD2 BTB (POZ) domain containing 2
C11ORF63 chromosome 11 open reading frame 63
CCDC71 coiled-coil domain containing 71
CFAP44 cilia and flagella associated protein 44
CFAP45 cilia and flagella associated protein 45
CLCA1 chloride channel accessory 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CXORF56 chromosome X open reading frame 56
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DNAL4 dynein, axonemal, light chain 4
EGF epidermal growth factor
EGR2 early growth response 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM184A family with sequence similarity 184, member A
FKBP10 FK506 binding protein 10, 65 kDa
FMO4 flavin containing monooxygenase 4
GDAP2 ganglioside induced differentiation associated protein 2
GLB1L galactosidase, beta 1-like
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
HCG4 HLA complex group 4 (non-protein coding)
HIST1H1D histone cluster 1, H1d
HIST1H4D histone cluster 1, H4d
HOXA2 homeobox A2
HOXC11 homeobox C11
IL17RB interleukin 17 receptor B
IL2 interleukin 2
IRF2 interferon regulatory factor 2
ITGA10 integrin, alpha 10
KIAA0754 KIAA0754
KRT86 keratin 86, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LNPEP leucyl/cystinyl aminopeptidase
LOC100287590 uncharacterized LOC100287590
LRRC6 leucine rich repeat containing 6
LRRK1 leucine-rich repeat kinase 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MANBA mannosidase, beta A, lysosomal
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEIS1 Meis homeobox 1
MMP3 matrix metallopeptidase 3
MOCS3 molybdenum cofactor synthesis 3
MYO1D myosin ID
NABP1 nucleic acid binding protein 1
NFS1 NFS1 cysteine desulfurase
NKX3-2 NK3 homeobox 2
NUP62CL nucleoporin 62kDa C-terminal like
OGFRL1 opioid growth factor receptor-like 1
OSMR oncostatin M receptor
PCDH17 protocadherin 17
PDE12 phosphodiesterase 12
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PODXL2 podocalyxin-like 2
POMT2 protein-O-mannosyltransferase 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRR4 proline rich 4 (lacrimal)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS17 regulator of G-protein signaling 17
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCAI suppressor of cancer cell invasion
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLITRK5 SLIT and NTRK-like family, member 5
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STK16 serine/threonine kinase 16
TMEM132A transmembrane protein 132A
TMEM159 transmembrane protein 159
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
TXK TXK tyrosine kinase
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VASH1 vasohibin 1
WDR4 WD repeat domain 4
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF428 zinc finger protein 428
ZNF510 zinc finger protein 510
ZNF671 zinc finger protein 671
ZNF702P zinc finger protein 702, pseudogene
ZNF778 zinc finger protein 778