thiostrepton-4385 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the thiostrepton-4385 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADM adrenomedullin
AMACR alpha-methylacyl-CoA racemase
APAF1 apoptotic peptidase activating factor 1
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ATF3 activating transcription factor 3
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BIN1 bridging integrator 1
C21ORF2 chromosome 21 open reading frame 2
CALB2 calbindin 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
COL7A1 collagen, type VII, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CSF1 colony stimulating factor 1 (macrophage)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ERO1LB ERO1-like beta (S. cerevisiae)
EXPH5 exophilin 5
F13B coagulation factor XIII, B polypeptide
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45G growth arrest and DNA-damage-inducible, gamma
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
GRPR gastrin-releasing peptide receptor
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HMOX1 heme oxygenase 1
HPCAL4 hippocalcin like 4
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF2-AS IGF2 antisense RNA
IL21R interleukin 21 receptor
INHBE inhibin, beta E
JAG1 jagged 1
KIAA0040 KIAA0040
KIF21B kinesin family member 21B
KRT16 keratin 16, type I
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100286895 cell division cycle 27 homolog pseudogene
LPIN1 lipin 1
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBD2 methyl-CpG binding domain protein 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MEF2D myocyte enhancer factor 2D
MIR22HG MIR22 host gene
MT3 metallothionein 3
NCOR2 nuclear receptor corepressor 2
NOD2 nucleotide-binding oligomerization domain containing 2
NRL neural retina leucine zipper
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
PALM paralemmin
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RHOBTB3 Rho-related BTB domain containing 3
RND1 Rho family GTPase 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX3 runt-related transcription factor 3
SEC24D SEC24 family member D
SH3BP2 SH3-domain binding protein 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS7 suppressor of cytokine signaling 7
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPTB spectrin, beta, erythrocytic
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX1 synovial sarcoma, X breakpoint 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYT11 synaptotagmin XI
SYT2 synaptotagmin II
TAOK2 TAO kinase 2
TBX10 T-box 10
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TREX1 three prime repair exonuclease 1
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
VWA5A von Willebrand factor A domain containing 5A
ZNF165 zinc finger protein 165
ZNF222 zinc finger protein 222
ZNF235 zinc finger protein 235
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
AMT aminomethyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMT1 acidic residue methyltransferase 1
ARPIN actin-related protein 2/3 complex inhibitor
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BHLHE41 basic helix-loop-helix family, member e41
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C19ORF73 chromosome 19 open reading frame 73
C1ORF159 chromosome 1 open reading frame 159
C7ORF43 chromosome 7 open reading frame 43
CCP110 centriolar coiled coil protein 110kDa
CFAP44 cilia and flagella associated protein 44
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CRIP1 cysteine-rich protein 1 (intestinal)
CUZD1 CUB and zona pellucida-like domains 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP2 dual specificity phosphatase 2
E2F8 E2F transcription factor 8
EGR3 early growth response 3
ELMO3 engulfment and cell motility 3
EPHA4 EPH receptor A4
FBXO5 F-box protein 5
FJX1 four jointed box 1 (Drosophila)
FRS2 fibroblast growth factor receptor substrate 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA4 GATA binding protein 4
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GUSBP3 glucuronidase, beta pseudogene 3
HDAC4 histone deacetylase 4
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HOXB2 homeobox B2
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IRF6 interferon regulatory factor 6
IRS1 insulin receptor substrate 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLHL25 kelch-like family member 25
LIN7A lin-7 homolog A (C. elegans)
LMNB1 lamin B1
LRRC37A3 leucine rich repeat containing 37, member A3
MOCS3 molybdenum cofactor synthesis 3
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NPY1R neuropeptide Y receptor Y1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
PCDHA6 protocadherin alpha 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK2 polo-like kinase 2
PTK6 protein tyrosine kinase 6
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RFTN1 raftlin, lipid raft linker 1
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPAP1 RNA polymerase II associated protein 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC12A9 solute carrier family 12, member 9
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYTL2 synaptotagmin-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TLR5 toll-like receptor 5
TOP3B topoisomerase (DNA) III beta
TPK1 thiamin pyrophosphokinase 1
TPSG1 tryptase gamma 1
TRIM21 tripartite motif containing 21
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC23 tetratricopeptide repeat domain 23
VASH2 vasohibin 2
VAV3 vav 3 guanine nucleotide exchange factor
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
WLS wntless Wnt ligand secretion mediator
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF350 zinc finger protein 350
ZNF480 zinc finger protein 480
ZNF696 zinc finger protein 696