thiostrepton Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent. (Chemical Entities of Biological Interest Ontology, CHEBI_29693)
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Genes

2 genes differentially expressed following the thiostrepton small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 4.1971
HSPA1A heat shock 70kDa protein 1A 3.60775