Pentalogy of Cantrell (POC) is a lethal multiple congenital anomalies syndrome, characterized by the presence of 5 major malformations: midline supraumbilical abdominal wall defect, lower sternal defect, diaphragmatic pericardial defect, anterior diaphragmatic defect and various congenital heart malformation (see this term). Ectopia cordis, (EC) dyspnea, cyanosis and lung infections are frequent. (Orphanet Rare Disease Ontology, Orphanet_1335)
