thrombin Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Thrombin is a trypsin-like serine protease protein that in humans is encoded by the F2 gene.[2][3] Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. (Experimental Factor Ontology, EFO_0003183)
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Genes

87 proteins co-occuring with the biological term thrombin in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACVR1B activin A receptor, type IB
ADD1 adducin 1 (alpha)
ADK adenosine kinase
ADRA2A adrenoceptor alpha 2A
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA2 annexin A2
AQP4 aquaporin 4
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
C6ORF25 chromosome 6 open reading frame 25
CALD1 caldesmon 1
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAV1 caveolin 1, caveolae protein, 22kDa
CFL1 cofilin 1 (non-muscle)
CHUK conserved helix-loop-helix ubiquitous kinase
CREB1 cAMP responsive element binding protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EZR ezrin
F11R F11 receptor
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FGB fibrinogen beta chain
FHOD1 formin homology 2 domain containing 1
FLNA filamin A, alpha
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H1C histone cluster 1, H1c
HSPB1 heat shock 27kDa protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LIMK1 LIM domain kinase 1
LY6G6F lymphocyte antigen 6 complex, locus G6F
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MGMT O-6-methylguanine-DNA methyltransferase
MSN moesin
MYL12B myosin, light chain 12B, regulatory
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NAGK N-acetylglucosamine kinase
NCF4 neutrophil cytosolic factor 4, 40kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG1 phospholipase C, gamma 1
PLEK pleckstrin
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PTK2 protein tyrosine kinase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1GAP2 RAP1 GTPase activating protein 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS18 regulator of G-protein signaling 18
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAP23 synaptosomal-associated protein, 23kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
VASP vasodilator-stimulated phosphoprotein
VTN vitronectin
WNK2 WNK lysine deficient protein kinase 2
YES1 YES proto-oncogene 1, Src family tyrosine kinase