thrombocytosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood. (Human Disease Ontology, DOID_2228)
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Genes

187 genes co-occuring with the disease thrombocytosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
JAK2 Janus kinase 2 3.09723
THPO thrombopoietin 2.51843
MPL MPL proto-oncogene, thrombopoietin receptor 2.1967
CD177 CD177 molecule 1.83636
TET2 tet methylcytosine dioxygenase 2 1.72456
RARS arginyl-tRNA synthetase 1.53348
ASXL1 additional sex combs like transcriptional regulator 1 1.46891
IL6 interleukin 6 1.46276
CALR calreticulin 1.44562
BCR breakpoint cluster region 1.34592
CD34 CD34 molecule 1.31843
CRP C-reactive protein, pentraxin-related 1.31187
ZNF77 zinc finger protein 77 1.30314
PF4 platelet factor 4 1.27519
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.22388
VWF von Willebrand factor 1.2018
IFNA1 interferon, alpha 1 1.20007
JAK1 Janus kinase 1 1.19057
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.17035
NFE2 nuclear factor, erythroid 2 1.14687
F2 coagulation factor II (thrombin) 1.10343
IL3 interleukin 3 1.09713
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.09587
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.08789
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.06564
EPOR erythropoietin receptor 1.06354
ALPPL2 alkaline phosphatase, placental-like 2 1.02187
ALPP alkaline phosphatase, placental 1.02144
ALPL alkaline phosphatase, liver/bone/kidney 1.02102
PROS1 protein S (alpha) 1.01385
F5 coagulation factor V (proaccelerin, labile factor) 1.00372
SH2B3 SH2B adaptor protein 3 0.990222
IFNA2 interferon, alpha 2 0.964986
F8 coagulation factor VIII, procoagulant component 0.964567
F3 coagulation factor III (thromboplastin, tissue factor) 0.95996
FIP1L1 factor interacting with PAPOLA and CPSF1 0.937044
EPO erythropoietin 0.920498
RPS14 ribosomal protein S14 0.918848
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.906086
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.881062
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.852402
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.851173
TYK2 tyrosine kinase 2 0.847078
KANK1 KN motif and ankyrin repeat domains 1 0.838885
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.826589
FTH1 ferritin, heavy polypeptide 1 0.795821
FTL ferritin, light polypeptide 0.795821
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.793361
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.770027
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.76431
AGO2 argonaute RISC catalytic component 2 0.736243
FGFR1 fibroblast growth factor receptor 1 0.735027
KIAA0355 KIAA0355 0.732596
THBD thrombomodulin 0.730166
IL11 interleukin 11 0.720461
SETD2 SET domain containing 2 0.71925
SMIM3 small integral membrane protein 3 0.706351
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.6939
ELN elastin 0.676706
IL1B interleukin 1, beta 0.672722
WDR43 WD repeat domain 43 0.668345
NAAA N-acylethanolamine acid amidase 0.650508
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.644586
PLG plasminogen 0.639857
FEN1 flap structure-specific endonuclease 1 0.63907
SOCS2 suppressor of cytokine signaling 2 0.633563
MPO myeloperoxidase 0.624143
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0.617877
SOX30 SRY (sex determining region Y)-box 30 0.611229
SOCS3 suppressor of cytokine signaling 3 0.606152
GARS glycyl-tRNA synthetase 0.577716
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.571884
RABGGTA Rab geranylgeranyltransferase, alpha subunit 0.564889
SRSF2 serine/arginine-rich splicing factor 2 0.560616
ALB albumin 0.558674
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.550522
GPX8 glutathione peroxidase 8 (putative) 0.549747
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.539667
JAK3 Janus kinase 3 0.530768
PTH parathyroid hormone 0.528835
CD33 CD33 molecule 0.52343
CCDC110 coiled-coil domain containing 110 0.499997
TGFB1 transforming growth factor, beta 1 0.489691
LGALS12 lectin, galactoside-binding, soluble, 12 0.488549
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.482464
VAV1 vav 1 guanine nucleotide exchange factor 0.476772
KIAA0226L KIAA0226-like 0.472225
CARD6 caspase recruitment domain family, member 6 0.471846
FLT3 fms-related tyrosine kinase 3 0.466172
HAMP hepcidin antimicrobial peptide 0.463527
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.452962
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.450324
CD79A CD79a molecule, immunoglobulin-associated alpha 0.447311
CSRP2 cysteine and glycine-rich protein 2 0.447311
CD36 CD36 molecule (thrombospondin receptor) 0.443547
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.43753
GGT1 gamma-glutamyltransferase 1 0.433397
ENOSF1 enolase superfamily member 1 0.428891
VEGFA vascular endothelial growth factor A 0.426265
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.42289
BCL2L1 BCL2-like 1 0.412779
CD63 CD63 molecule 0.400826
IL6R interleukin 6 receptor 0.400826
TYMP thymidine phosphorylase 0.393746
DEFA4 defensin, alpha 4, corticostatin 0.389281
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.388909
ZC3H13 zinc finger CCCH-type containing 13 0.382966
PGK1 phosphoglycerate kinase 1 0.379256
NFIB nuclear factor I/B 0.371477
MYSM1 Myb-like, SWIRM and MPN domains 1 0.370368
CD7 CD7 molecule 0.36741
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.366671
SERINC5 serine incorporator 5 0.364085
RUNX1 runt-related transcription factor 1 0.361502
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.359657
MIR190A microRNA 190a 0.355235
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.354499
HP haptoglobin 0.343106
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.338707
HPR haptoglobin-related protein 0.337242
ZNF165 zinc finger protein 165 0.333949
EVPL envoplakin 0.333218
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.332487
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.3292
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.326646
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.324094
SCARB2 scavenger receptor class B, member 2 0.31029
GBP2 guanylate binding protein 2, interferon-inducible 0.30631
PLAT plasminogen activator, tissue 0.305948
ZFPM1 zinc finger protein, FOG family member 1 0.305948
ETV6 ets variant 6 0.301615
CD59 CD59 molecule, complement regulatory protein 0.301254
NF1 neurofibromin 1 0.299452
SSBP2 single-stranded DNA binding protein 2 0.294413
ANXA5 annexin A5 0.290103
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.289744
MIR145 microRNA 145 0.279011
IL1RN interleukin 1 receptor antagonist 0.277227
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.274021
AR androgen receptor 0.268332
ACHE acetylcholinesterase (Yt blood group) 0.267977
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.266203
GAS2 growth arrest-specific 2 0.263368
SCARB1 scavenger receptor class B, member 1 0.256652
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.249257
IDS iduronate 2-sulfatase 0.245396
PAWR PRKC, apoptosis, WT1, regulator 0.237706
G6PD glucose-6-phosphate dehydrogenase 0.235616
GPS2 G protein pathway suppressor 2 0.23353
ITGB5 integrin, beta 5 0.232142
CD40LG CD40 ligand 0.230755
JARID2 jumonji, AT rich interactive domain 2 0.230063
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.226952
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.22145
IL1A interleukin 1, alpha 0.220081
CAPRIN2 caprin family member 2 0.220081
HAUS3 HAUS augmin-like complex, subunit 3 0.21974
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.219057
RNF19B ring finger protein 19B 0.218715
TNF tumor necrosis factor 0.218374
CD164 CD164 molecule, sialomucin 0.217012
CXCL12 chemokine (C-X-C motif) ligand 12 0.214297
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.210925
FPR1 formyl peptide receptor 1 0.210253
TP53 tumor protein p53 0.209583
DAAM1 dishevelled associated activator of morphogenesis 1 0.205916
BMP10 bone morphogenetic protein 10 0.200982
SESN2 sestrin 2 0.200982
HDAC9 histone deacetylase 9 0.200656
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.200656
AFP alpha-fetoprotein 0.200006
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.196459
TAGAP T-cell activation RhoGTPase activating protein 0.190786
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.18621
HAGH hydroxyacylglutathione hydrolase 0.183248
CDK13 cyclin-dependent kinase 13 0.17896
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.173571
SETBP1 SET binding protein 1 0.173057
FMN2 formin 2 0.173057
LIN7A lin-7 homolog A (C. elegans) 0.172038
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.171036
TBXA2R thromboxane A2 receptor 0.167682
ETHE1 ethylmalonic encephalopathy 1 0.167682
LIN9 lin-9 DREAM MuvB core complex component 0.165655
LDHC lactate dehydrogenase C 0.163729
IL2 interleukin 2 0.161716
DLK1 delta-like 1 homolog (Drosophila) 0.159302