thyrotoxicosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that is characterized by excess thyroid hormone. (Human Disease Ontology, DOID_7997)
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Genes

107 genes co-occuring with the disease thyrotoxicosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TRH thyrotropin-releasing hormone 2.15199
TG thyroglobulin 1.98575
TSHR thyroid stimulating hormone receptor 1.98156
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.85319
THRB thyroid hormone receptor, beta 1.5943
TXNRD2 thioredoxin reductase 2 1.59028
TPO thyroid peroxidase 1.45968
INS insulin 1.16136
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.10048
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.07236
SHBG sex hormone-binding globulin 1.0606
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.05807
PTH parathyroid hormone 0.987693
GPHB5 glycoprotein hormone beta 5 0.960378
IYD iodotyrosine deiodinase 0.950352
ALPPL2 alkaline phosphatase, placental-like 2 0.948269
ALPP alkaline phosphatase, placental 0.947852
ALPL alkaline phosphatase, liver/bone/kidney 0.947019
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.94577
DIO3 deiodinase, iodothyronine, type III 0.908965
BGLAP bone gamma-carboxyglutamate (gla) protein 0.897051
ALB albumin 0.886389
PCDHA1 protocadherin alpha 1 0.883111
CALCA calcitonin-related polypeptide alpha 0.872053
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.869596
IFNA1 interferon, alpha 1 0.860999
TTR transthyretin 0.859771
PRELID1 PRELI domain containing 1 0.834378
SST somatostatin 0.829459
POMC proopiomelanocortin 0.791311
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.781479
DIO2 deiodinase, iodothyronine, type II 0.745172
GCG glucagon 0.736649
DNAH8 dynein, axonemal, heavy chain 8 0.732596
AMD1 adenosylmethionine decarboxylase 1 0.699116
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.66199
DIO1 deiodinase, iodothyronine, type I 0.66199
THRSP thyroid hormone responsive 0.635921
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.616703
GPHA2 glycoprotein hormone alpha 2 0.614747
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.613574
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.610448
ABR active BCR-related 0.572662
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 0.566831
ACSM2A acyl-CoA synthetase medium-chain family member 2A 0.560227
IL6 interleukin 6 0.552075
GHRL ghrelin/obestatin prepropeptide 0.549359
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.518805
GHRH growth hormone releasing hormone 0.506507
GNAS GNAS complex locus 0.499231
PRL prolactin 0.477909
LXN latexin 0.469197
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.465794
CA1 carbonic anhydrase I 0.460129
COL1A2 collagen, type I, alpha 2 0.458996
IGF1 insulin-like growth factor 1 (somatomedin C) 0.456732
REN renin 0.452208
CRP C-reactive protein, pentraxin-related 0.444676
NODAL nodal growth differentiation factor 0.427765
NUCB2 nucleobindin 2 0.42664
LEP leptin 0.419142
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.409787
PROP1 PROP paired-like homeobox 1 0.402505
TOX thymocyte selection-associated high mobility group box 0.384822
AKTIP AKT interacting protein 0.384451
TSHB thyroid stimulating hormone, beta 0.365562
CS citrate synthase 0.348614
TBCA tubulin folding cofactor A 0.341272
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.339806
NPPA natriuretic peptide A 0.328469
ASMT acetylserotonin O-methyltransferase 0.325916
HLA-A major histocompatibility complex, class I, A 0.275445
LIPE lipase, hormone-sensitive 0.268687
TLK2 tousled-like kinase 2 0.267977
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.265849
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.265494
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.264785
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.261952
PCDH11Y protocadherin 11 Y-linked 0.259124
LCT lactase 0.256122
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.255594
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.251366
LHX3 LIM homeobox 3 0.250311
LPO lactoperoxidase 0.247501
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.242595
ADM adrenomedullin 0.233183
IL2 interleukin 2 0.232836
F2 coagulation factor II (thrombin) 0.231102
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.229716
HECA headcase homolog (Drosophila) 0.21974
PCDH11X protocadherin 11 X-linked 0.218034
SIX6 SIX homeobox 6 0.210925
CLCN6 chloride channel, voltage-sensitive 6 0.210589
MYBPC1 myosin binding protein C, slow type 0.202618
MGP matrix Gla protein 0.199356
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.199033
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.197099
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.191719
ACHE acetylcholinesterase (Yt blood group) 0.181222
CTRL chymotrypsin-like 0.176485
RSPO1 R-spondin 1 0.172799
CAPNS1 calpain, small subunit 1 0.170054
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.165001
GH1 growth hormone 1 0.164571
PAX8 paired box 8 0.162707
YME1L1 YME1-like 1 ATPase 0.158951
CTSD cathepsin D 0.158434