tia1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TIA1 cytotoxic granule-associated RNA binding protein|The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7072)
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Genes

21 genes co-occuring with the biological term tia1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
CD68 CD68 molecule
COL2A1 collagen, type II, alpha 1
FASTK Fas-activated serine/threonine kinase
FGFR2 fibroblast growth factor receptor 2
FOXP3 forkhead box P3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HTT huntingtin
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SMN2 survival of motor neuron 2, centromeric
SNRPC small nuclear ribonucleoprotein polypeptide C
SRSF3 serine/arginine-rich splicing factor 3
TARDBP TAR DNA binding protein
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
WT1 Wilms tumor 1