tiaprofenic acid-4091 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the tiaprofenic acid-4091 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY10 adenylate cyclase 10 (soluble)
ADRA1A adrenoceptor alpha 1A
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
APOB apolipoprotein B
APOC4 apolipoprotein C-IV
ATXN3L ataxin 3-like
BEST1 bestrophin 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP3 bone morphogenetic protein 3
C11ORF16 chromosome 11 open reading frame 16
C8A complement component 8, alpha polypeptide
C9ORF9 chromosome 9 open reading frame 9
CCL5 chemokine (C-C motif) ligand 5
CD244 CD244 molecule, natural killer cell receptor 2B4
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CERS4 ceramide synthase 4
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
COL14A1 collagen, type XIV, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DAAM2 dishevelled associated activator of morphogenesis 2
ESR1 estrogen receptor 1
ETV3 ets variant 3
EXOSC1 exosome component 1
FGF18 fibroblast growth factor 18
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAS7 growth arrest-specific 7
GIP gastric inhibitory polypeptide
GJA8 gap junction protein, alpha 8, 50kDa
GRM8 glutamate receptor, metabotropic 8
GUCA2A guanylate cyclase activator 2A (guanylin)
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GYPC glycophorin C (Gerbich blood group)
HFE hemochromatosis
HOXD13 homeobox D13
HPR haptoglobin-related protein
HSPB3 heat shock 27kDa protein 3
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB8 integrin, beta 8
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLK2 kallikrein-related peptidase 2
KRTAP5-9 keratin associated protein 5-9
LEFTY2 left-right determination factor 2
LEP leptin
LGALS4 lectin, galactoside-binding, soluble, 4
LIMD2 LIM domain containing 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MBD2 methyl-CpG binding domain protein 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCF1C neutrophil cytosolic factor 1C pseudogene
NEURL1 neuralized E3 ubiquitin protein ligase 1
NMUR1 neuromedin U receptor 1
NOTCH4 notch 4
NOX4 NADPH oxidase 4
OLIG2 oligodendrocyte lineage transcription factor 2
OMD osteomodulin
PBX1 pre-B-cell leukemia homeobox 1
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH11Y protocadherin 11 Y-linked
PDE12 phosphodiesterase 12
PHF3 PHD finger protein 3
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PKD2L2 polycystic kidney disease 2-like 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POM121 POM121 transmembrane nucleoporin
POM121L2 POM121 transmembrane nucleoporin-like 2
PPARD peroxisome proliferator-activated receptor delta
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRTN3 proteinase 3
RDH8 retinol dehydrogenase 8 (all-trans)
RET ret proto-oncogene
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RNF126P1 ring finger protein 126 pseudogene 1
RRH retinal pigment epithelium-derived rhodopsin homolog
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC45A2 solute carrier family 45, member 2
SPANXC SPANX family, member C
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPRR2B small proline-rich protein 2B
SRPK3 SRSF protein kinase 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SUGP1 SURP and G patch domain containing 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TACR1 tachykinin receptor 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TESPA1 thymocyte expressed, positive selection associated 1
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TPP1 tripeptidyl peptidase I
TRGV5 T cell receptor gamma variable 5
TRPC4 transient receptor potential cation channel, subfamily C, member 4
WNT3 wingless-type MMTV integration site family, member 3
ZNF613 zinc finger protein 613

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADCY6 adenylate cyclase 6
AEN apoptosis enhancing nuclease
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARSJ arylsulfatase family, member J
AXIN1 axin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BICC1 BicC family RNA binding protein 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD79B CD79b molecule, immunoglobulin-associated beta
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CINP cyclin-dependent kinase 2 interacting protein
CLDN15 claudin 15
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CNN1 calponin 1, basic, smooth muscle
CSRNP3 cysteine-serine-rich nuclear protein 3
CTC1 CTS telomere maintenance complex component 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYB5R2 cytochrome b5 reductase 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNAL4 dynein, axonemal, light chain 4
ECE1 endothelin converting enzyme 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM118A family with sequence similarity 118, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF1 fibroblast growth factor 1 (acidic)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HOXA1 homeobox A1
HOXA6 homeobox A6
HSF2BP heat shock transcription factor 2 binding protein
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IPO8 importin 8
ISYNA1 inositol-3-phosphate synthase 1
KIFC3 kinesin family member C3
KRT86 keratin 86, type II
LAMA5 laminin, alpha 5
LMNB1 lamin B1
LRP4 low density lipoprotein receptor-related protein 4
MAGEF1 melanoma antigen family F1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFSD6 major facilitator superfamily domain containing 6
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTCP1 mature T-cell proliferation 1
MXD3 MAX dimerization protein 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOL12 nucleolar protein 12
NT5DC3 5'-nucleotidase domain containing 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
POLE polymerase (DNA directed), epsilon, catalytic subunit
PTK7 protein tyrosine kinase 7 (inactive)
PXMP4 peroxisomal membrane protein 4, 24kDa
RECQL4 RecQ protein-like 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNDC3B RUN domain containing 3B
RUSC2 RUN and SH3 domain containing 2
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SETDB1 SET domain, bifurcated 1
SIX1 SIX homeobox 1
SLC16A6 solute carrier family 16, member 6
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNIP1 Smad nuclear interacting protein 1
SSTR4 somatostatin receptor 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TENM4 teneurin transmembrane protein 4
TMEM209 transmembrane protein 209
TMSB15A thymosin beta 15a
TRAF2 TNF receptor-associated factor 2
TSPAN2 tetraspanin 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP18 ubiquitin specific peptidase 18
WDR4 WD repeat domain 4
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF10 zinc finger protein 10
ZNF137P zinc finger protein 137, pseudogene
ZNF280D zinc finger protein 280D
ZNF34 zinc finger protein 34
ZNF408 zinc finger protein 408
ZNF76 zinc finger protein 76