ticlopidine-1895 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ticlopidine-1895 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACVR2B activin A receptor, type IIB
AKAP13 A kinase (PRKA) anchor protein 13
ALPK1 alpha-kinase 1
BCL2 B-cell CLL/lymphoma 2
BMP2 bone morphogenetic protein 2
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C6 complement component 6
C7ORF43 chromosome 7 open reading frame 43
CD53 CD53 molecule
CDK12 cyclin-dependent kinase 12
CHPF2 chondroitin polymerizing factor 2
CNGB3 cyclic nucleotide gated channel beta 3
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNPY3 canopy FGF signaling regulator 3
COL5A3 collagen, type V, alpha 3
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DRD5 dopamine receptor D5
EGR4 early growth response 4
EIF1 eukaryotic translation initiation factor 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FGFR4 fibroblast growth factor receptor 4
FSCN1 fascin actin-bundling protein 1
FSD1 fibronectin type III and SPRY domain containing 1
FZD8 frizzled class receptor 8
GJB1 gap junction protein, beta 1, 32kDa
GJD2 gap junction protein, delta 2, 36kDa
GNL1 guanine nucleotide binding protein-like 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
HOXB7 homeobox B7
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFI16 interferon, gamma-inducible protein 16
IFIH1 interferon induced with helicase C domain 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLHL18 kelch-like family member 18
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LYPD3 LY6/PLAUR domain containing 3
MASP2 mannan-binding lectin serine peptidase 2
MICALL2 MICAL-like 2
MPDZ multiple PDZ domain protein
MX1 MX dynamin-like GTPase 1
MYO1E myosin IE
N4BP2L1 NEDD4 binding protein 2-like 1
NADK NAD kinase
NPPA natriuretic peptide A
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT2 nuclear transport factor 2-like export factor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGFR opioid growth factor receptor
OLFML2A olfactomedin-like 2A
OR6A2 olfactory receptor, family 6, subfamily A, member 2
PDCL phosducin-like
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLK3 polo-like kinase 3
PNISR PNN-interacting serine/arginine-rich protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRDM11 PR domain containing 11
PRDX2 peroxiredoxin 2
PSD4 pleckstrin and Sec7 domain containing 4
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RGS12 regulator of G-protein signaling 12
RNF121 ring finger protein 121
RPL14 ribosomal protein L14
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SQSTM1 sequestosome 1
STARD8 StAR-related lipid transfer (START) domain containing 8
SYT13 synaptotagmin XIII
TAOK1 TAO kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRB thyroid hormone receptor, beta
TMEM70 transmembrane protein 70
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAPPC11 trafficking protein particle complex 11
TRAPPC2 trafficking protein particle complex 2
TRIM45 tripartite motif containing 45
TSHZ2 teashirt zinc finger homeobox 2
TSN translin
TSPAN15 tetraspanin 15
USF2 upstream transcription factor 2, c-fos interacting
USP48 ubiquitin specific peptidase 48
WNT5A wingless-type MMTV integration site family, member 5A
ZC3H7B zinc finger CCCH-type containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF688 zinc finger protein 688
ZNF710 zinc finger protein 710
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APH1A APH1A gamma secretase subunit
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASB6 ankyrin repeat and SOCS box containing 6
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
BARD1 BRCA1 associated RING domain 1
BCL2A1 BCL2-related protein A1
C1ORF35 chromosome 1 open reading frame 35
C21ORF59 chromosome 21 open reading frame 59
C9ORF3 chromosome 9 open reading frame 3
CLK3 CDC-like kinase 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COMMD8 COMM domain containing 8
CPOX coproporphyrinogen oxidase
DDA1 DET1 and DDB1 associated 1
DPP3 dipeptidyl-peptidase 3
DUSP12 dual specificity phosphatase 12
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ECHDC1 ethylmalonyl-CoA decarboxylase 1
ERCC3 excision repair cross-complementation group 3
ETV4 ets variant 4
EXOC5 exocyst complex component 5
FAF1 Fas (TNFRSF6) associated factor 1
FAM127B family with sequence similarity 127, member B
FAM188A family with sequence similarity 188, member A
FAM222B family with sequence similarity 222, member B
FKBP2 FK506 binding protein 2, 13kDa
FNBP4 formin binding protein 4
GEMIN4 gem (nuclear organelle) associated protein 4
GLMN glomulin, FKBP associated protein
GOLGA7 golgin A7
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
H2BFS H2B histone family, member S (pseudogene)
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-J major histocompatibility complex, class I, J (pseudogene)
IL15RA interleukin 15 receptor, alpha
IL24 interleukin 24
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITM2C integral membrane protein 2C
JUNB jun B proto-oncogene
KRT34 keratin 34, type I
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LHX6 LIM homeobox 6
MAD2L1BP MAD2L1 binding protein
MARC1 mitochondrial amidoxime reducing component 1
MCM10 minichromosome maintenance complex component 10
MICA MHC class I polypeptide-related sequence A
MYL12B myosin, light chain 12B, regulatory
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDE1 nudE neurodevelopment protein 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NFE2L2 nuclear factor, erythroid 2-like 2
NINJ1 ninjurin 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NXPH4 neurexophilin 4
PEPD peptidase D
PES1 pescadillo ribosomal biogenesis factor 1
PFDN1 prefoldin subunit 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
POGLUT1 protein O-glucosyltransferase 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
RAB36 RAB36, member RAS oncogene family
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL11 ribosomal protein L11
SAV1 salvador family WW domain containing protein 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SPDL1 spindle apparatus coiled-coil protein 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SUN2 Sad1 and UNC84 domain containing 2
TCTN1 tectonic family member 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP11 THAP domain containing 11
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TRAIP TRAF interacting protein
TSG101 tumor susceptibility 101
TULP4 tubby like protein 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WDR5B WD repeat domain 5B
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF263 zinc finger protein 263
ZNF394 zinc finger protein 394
ZNF532 zinc finger protein 532
ZNF552 zinc finger protein 552
ZNHIT2 zinc finger, HIT-type containing 2