ticlopidine-4074 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ticlopidine-4074 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADD2 adducin 2 (beta)
ALDOB aldolase B, fructose-bisphosphate
APOE apolipoprotein E
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BEGAIN brain-enriched guanylate kinase-associated
C11ORF21 chromosome 11 open reading frame 21
C16ORF70 chromosome 16 open reading frame 70
C2CD2L C2CD2-like
C3 complement component 3
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCDC33 coiled-coil domain containing 33
CCKAR cholecystokinin A receptor
CD247 CD247 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEND1 cell cycle exit and neuronal differentiation 1
CIC capicua transcriptional repressor
COL10A1 collagen, type X, alpha 1
CXCR3 chemokine (C-X-C motif) receptor 3
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
ECE2 endothelin converting enzyme 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPX eosinophil peroxidase
EVX1 even-skipped homeobox 1
EXOSC1 exosome component 1
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FRK fyn-related Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GJA4 gap junction protein, alpha 4, 37kDa
GLB1L galactosidase, beta 1-like
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HBB hemoglobin, beta
HNF4A hepatocyte nuclear factor 4, alpha
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
ICOSLG inducible T-cell co-stimulator ligand
IMPG2 interphotoreceptor matrix proteoglycan 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KANK3 KN motif and ankyrin repeat domains 3
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIF25 kinesin family member 25
KRT38 keratin 38, type I
KSR1 kinase suppressor of ras 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LEP leptin
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMX1B LIM homeobox transcription factor 1, beta
LRRC61 leucine rich repeat containing 61
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSP1 lymphocyte-specific protein 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MEFV Mediterranean fever
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSR1 macrophage scavenger receptor 1
NCALD neurocalcin delta
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRXN2 neurexin 2
OSM oncostatin M
PAOX polyamine oxidase (exo-N4-amino)
PDE4DIP phosphodiesterase 4D interacting protein
PDE5A phosphodiesterase 5A, cGMP-specific
PIGR polymeric immunoglobulin receptor
PPARD peroxisome proliferator-activated receptor delta
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RHAG Rh-associated glycoprotein
RNF122 ring finger protein 122
RYR1 ryanodine receptor 1 (skeletal)
SARM1 sterile alpha and TIR motif containing 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFRP1 secreted frizzled-related protein 1
SH3PXD2A SH3 and PX domains 2A
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC22A14 solute carrier family 22, member 14
SLC39A9 solute carrier family 39, member 9
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPN sialophorin
STOML1 stomatin (EPB72)-like 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAT tyrosine aminotransferase
TBX1 T-box 1
TCF3 transcription factor 3
TLX2 T-cell leukemia homeobox 2
TMPRSS11E transmembrane protease, serine 11E
TP63 tumor protein p63
TRPM6 transient receptor potential cation channel, subfamily M, member 6
USH1C Usher syndrome 1C (autosomal recessive, severe)
VAC14 Vac14 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZNF613 zinc finger protein 613
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAD10 acyl-CoA dehydrogenase family, member 10
ACVR2B activin A receptor, type IIB
ALPK1 alpha-kinase 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BFSP1 beaded filament structural protein 1, filensin
C5ORF42 chromosome 5 open reading frame 42
CARD8 caspase recruitment domain family, member 8
CDK6 cyclin-dependent kinase 6
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHRDL1 chordin-like 1
CTC1 CTS telomere maintenance complex component 1
CTSK cathepsin K
CXORF56 chromosome X open reading frame 56
DAGLA diacylglycerol lipase, alpha
DIXDC1 DIX domain containing 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNA3 ephrin-A3
EN1 engrailed homeobox 1
EPN3 epsin 3
FAM13B family with sequence similarity 13, member B
FAM160B2 family with sequence similarity 160, member B2
FGF13 fibroblast growth factor 13
FOXC1 forkhead box C1
FURIN furin (paired basic amino acid cleaving enzyme)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H1D histone cluster 1, H1d
HYAL3 hyaluronoglucosaminidase 3
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM5C lysine (K)-specific demethylase 5C
KIF18B kinesin family member 18B
LIF leukemia inhibitory factor
LIME1 Lck interacting transmembrane adaptor 1
MCC mutated in colorectal cancers
MFGE8 milk fat globule-EGF factor 8 protein
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRSN2 neurensin 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP62CL nucleoporin 62kDa C-terminal like
NXPH4 neurexophilin 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
OSR2 odd-skipped related transciption factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PCSK7 proprotein convertase subtilisin/kexin type 7
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1 PDZ domain containing 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRR15L proline rich 15-like
PRR16 proline rich 16
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RWDD2A RWD domain containing 2A
SAYSD1 SAYSVFN motif domain containing 1
SETD1B SET domain containing 1B
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFXN3 sideroflexin 3
SIRT6 sirtuin 6
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
SOD3 superoxide dismutase 3, extracellular
STARD13 StAR-related lipid transfer (START) domain containing 13
STARD5 StAR-related lipid transfer (START) domain containing 5
STEAP4 STEAP family member 4
TBX3 T-box 3
TKFC triokinase/FMN cyclase
TMEM156 transmembrane protein 156
TMEM209 transmembrane protein 209
TMEM62 transmembrane protein 62
TRAPPC13 trafficking protein particle complex 13
TUBG2 tubulin, gamma 2
ULK1 unc-51 like autophagy activating kinase 1
USP18 ubiquitin specific peptidase 18
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF215 zinc finger protein 215
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNF623 zinc finger protein 623
ZNF702P zinc finger protein 702, pseudogene
ZNF76 zinc finger protein 76
ZW10 zw10 kinetochore protein