tight junction Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link http://amigo.geneontology.org/amigo/term/GO:0070160
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Genes

97 proteins localized to the tight junction cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
AFDN afadin, adherens junction formation factor
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AOC1 amine oxidase, copper containing 1
BVES blood vessel epicardial substance
CDH5 cadherin 5, type 2 (vascular endothelium)
CGN cingulin
CGNL1 cingulin-like 1
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN24 claudin 24
CLDN25 claudin 25
CLDN3 claudin 3
CLDN34 claudin 34
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CLMP CXADR-like membrane protein
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
CYTH3 cytohesin 3
DLG1 discs, large homolog 1 (Drosophila)
DSG3 desmoglein 3
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EPPK1 epiplakin 1
F11R F11 receptor
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
FRMPD2 FERM and PDZ domain containing 2
GJA1 gap junction protein, alpha 1, 43kDa
IGSF5 immunoglobulin superfamily, member 5
ILDR1 immunoglobulin-like domain containing receptor 1
ILDR2 immunoglobulin-like domain containing receptor 2
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
JAML junction adhesion molecule like
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LSR lipolysis stimulated lipoprotein receptor
LUZP1 leucine zipper protein 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MICALL2 MICAL-like 2
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MTDH metadherin
OCEL1 occludin/ELL domain containing 1
OCLN occludin
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PATJ PATJ crumbs cell polarity complex component
POF1B premature ovarian failure, 1B
POTEF POTE ankyrin domain family, member F
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RAB13 RAB13, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIGI RNA sensor RIG-I
SH3BP1 SH3-domain binding protein 1
SHROOM2 shroom family member 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
STRN striatin, calmodulin binding protein
TBCD tubulin folding cofactor D
TGFBR1 transforming growth factor, beta receptor 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
UBN1 ubinuclein 1
USP53 ubiquitin specific peptidase 53
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WNK3 WNK lysine deficient protein kinase 3
WNK4 WNK lysine deficient protein kinase 4
YBX3 Y box binding protein 3