tight junction Gene Set

Dataset LOCATE Curated Protein Localization Annotations
Category proteomics
Type cellular component
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link http://locate.imb.uq.edu.au/searchpages/HumanGO:0005923.shtml
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25 proteins localized to the tight junction cellular component in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.

Symbol Name
AMOT angiomotin
ARHGAP17 Rho GTPase activating protein 17
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN2 claudin 2
CLDN3 claudin 3
CLDN5 claudin 5
CLDN6 claudin 6
CLDN9 claudin 9
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
ILK integrin-linked kinase
JAM2 junctional adhesion molecule 2
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTDH metadherin
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PTPRS protein tyrosine phosphatase, receptor type, S
SYNPO synaptopodin
TJP1 tight junction protein 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WNK4 WNK lysine deficient protein kinase 4