tight Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

315 genes co-occuring with the biological term tight in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACTN4 actinin, alpha 4
AGER advanced glycosylation end product-specific receptor
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMOT angiomotin
AMOTL1 angiomotin like 1
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
ATF2 activating transcription factor 2
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATR ATR serine/threonine kinase
BAAT bile acid CoA:amino acid N-acyltransferase
BAIAP2 BAI1-associated protein 2
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BORA bora, aurora kinase A activator
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASR calcium-sensing receptor
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD209 CD209 molecule
CD24 CD24 molecule
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDT1 chromatin licensing and DNA replication factor 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CGN cingulin
CGNL1 cingulin-like 1
CHMP3 charged multivesicular body protein 3
CIITA class II, major histocompatibility complex, transactivator
CKAP2 cytoskeleton associated protein 2
CLCN2 chloride channel, voltage-sensitive 2
CLDN1 claudin 1
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN2 claudin 2
CLDN3 claudin 3
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLMP CXADR-like membrane protein
CLTC clathrin, heavy chain (Hc)
CNR1 cannabinoid receptor 1 (brain)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRB3 crumbs family member 3
CSK c-src tyrosine kinase
CTAG1B cancer/testis antigen 1B
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLG1 discs, large homolog 1 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DSG2 desmoglein 2
DTNA dystrobrevin, alpha
ECT2 epithelial cell transforming 2
EFNB2 ephrin-B2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
EZR ezrin
F10 coagulation factor X
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGA fibrinogen alpha chain
FGF7 fibroblast growth factor 7
FHOD1 formin homology 2 domain containing 1
FLG filaggrin
FLNA filamin A, alpha
FOXM1 forkhead box M1
FOXO4 forkhead box O4
FTO fat mass and obesity associated
FXYD3 FXYD domain containing ion transport regulator 3
GAB1 GRB2-associated binding protein 1
GHRL ghrelin/obestatin prepropeptide
GKN1 gastrokine 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR39 G protein-coupled receptor 39
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
GUCA1A guanylate cyclase activator 1A (retina)
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2R insulin-like growth factor 2 receptor
IL18 interleukin 18
IL1B interleukin 1, beta
IL24 interleukin 24
IL4 interleukin 4
INADL InaD-like (Drosophila)
INCENP inner centromere protein antigens 135/155kDa
INSL4 insulin-like 4 (placenta)
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JAK1 Janus kinase 1
JAM3 junctional adhesion molecule 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
LHB luteinizing hormone beta polypeptide
LSR lipolysis stimulated lipoprotein receptor
LYPD3 LY6/PLAUR domain containing 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MIR122 microRNA 122
MIR21 microRNA 21
MIR302A microRNA 302a
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPDZ multiple PDZ domain protein
MPG N-methylpurine-DNA glycosylase
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTA2 metastasis associated 1 family, member 2
MTDH metadherin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
MYLK3 myosin light chain kinase 3
MYO9B myosin IXB
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NCSTN nicastrin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NXPH1 neurexophilin 1
OCLN occludin
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARD3 par-3 family cell polarity regulator
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PHF13 PHD finger protein 13
PICK1 protein interacting with PRKCA 1
PITX2 paired-like homeodomain 2
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLCG1 phospholipase C, gamma 1
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLG plasminogen
PLK1 polo-like kinase 1
POU2F1 POU class 2 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRKCZ protein kinase C, zeta
PRKD3 protein kinase D3
PRL prolactin
PRNP prion protein
PTEN phosphatase and tensin homolog
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTK2 protein tyrosine kinase 2
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB13 RAB13, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RAN RAN, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCC1 regulator of chromosome condensation 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOB ras homolog family member B
RHOU ras homolog family member U
RIMS2 regulating synaptic membrane exocytosis 2
RNASE3 ribonuclease, RNase A family, 3
RND3 Rho family GTPase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROMO1 reactive oxygen species modulator 1
RPGR retinitis pigmentosa GTPase regulator
RPL11 ribosomal protein L11
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
RYR2 ryanodine receptor 2 (cardiac)
S100A10 S100 calcium binding protein A10
SCN2A sodium channel, voltage gated, type II alpha subunit
SCRIB scribbled planar cell polarity protein
SEC61B Sec61 beta subunit
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHH sonic hedgehog
SIAH2 siah E3 ubiquitin protein ligase 2
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNAI1 snail family zinc finger 1
SORBS2 sorbin and SH3 domain containing 2
SOS1 son of sevenless homolog 1 (Drosophila)
SPDYA speedy/RINGO cell cycle regulator family member A
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPIRE1 spire-type actin nucleation factor 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SST somatostatin
SSTR3 somatostatin receptor 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM1 stromal interaction molecule 1
STIM2 stromal interaction molecule 2
SYMPK symplekin
SYNPO synaptopodin
SYT2 synaptotagmin II
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBI transforming growth factor, beta-induced, 68kDa
TGM3 transglutaminase 3
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
TLR2 toll-like receptor 2
TMPRSS2 transmembrane protease, serine 2
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TRAF4 TNF receptor-associated factor 4
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UBN1 ubinuclein 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP22 ubiquitin specific peptidase 22
VASP vasodilator-stimulated phosphoprotein
VCP valosin containing protein
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
YBX3 Y box binding protein 3
ZYX zyxin