tiletamine-3137 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tiletamine-3137 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ACBD4 acyl-CoA binding domain containing 4
ADGRL2 adhesion G protein-coupled receptor L2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMPH amphiphysin
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARMCX4 armadillo repeat containing, X-linked 4
ARSB arylsulfatase B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF16 chromosome 11 open reading frame 16
C3ORF18 chromosome 3 open reading frame 18
C4BPA complement component 4 binding protein, alpha
CA5B carbonic anhydrase VB, mitochondrial
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCDC57 coiled-coil domain containing 57
CD300A CD300a molecule
CDON cell adhesion associated, oncogene regulated
CFAP69 cilia and flagella associated protein 69
CFAP70 cilia and flagella associated protein 70
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CNPY4 canopy FGF signaling regulator 4
COL7A1 collagen, type VII, alpha 1
COL9A3 collagen, type IX, alpha 3
CPA4 carboxypeptidase A4
CRABP2 cellular retinoic acid binding protein 2
CRTC1 CREB regulated transcription coactivator 1
CSF1 colony stimulating factor 1 (macrophage)
DAAM2 dishevelled associated activator of morphogenesis 2
DLG3 discs, large homolog 3 (Drosophila)
DOCK6 dedicator of cytokinesis 6
DOK3 docking protein 3
DPP4 dipeptidyl-peptidase 4
DTNA dystrobrevin, alpha
EDA ectodysplasin A
FAM120C family with sequence similarity 120C
FBXO31 F-box protein 31
FGB fibrinogen beta chain
FLOT1 flotillin 1
FRMD4B FERM domain containing 4B
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLB1L galactosidase, beta 1-like
GLE1 GLE1 RNA export mediator
GPR22 G protein-coupled receptor 22
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H2AJ histone cluster 1, H2aj
HSDL2 hydroxysteroid dehydrogenase like 2
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL1R2 interleukin 1 receptor, type II
KIAA0319L KIAA0319-like
KRTAP2-4 keratin associated protein 2-4
LAMC3 laminin, gamma 3
LIME1 Lck interacting transmembrane adaptor 1
LOXL3 lysyl oxidase-like 3
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC23 leucine rich repeat containing 23
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP4 microtubule-associated protein 4
MNMIP1 manchette microtubule inner protein 1
MRPL41 mitochondrial ribosomal protein L41
MUC1 mucin 1, cell surface associated
OPRL1 opiate receptor-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PEX1 peroxisomal biogenesis factor 1
PKNOX2 PBX/knotted 1 homeobox 2
PLCE1 phospholipase C, epsilon 1
PLD2 phospholipase D2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPARD peroxisome proliferator-activated receptor delta
PRPH2 peripherin 2 (retinal degeneration, slow)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBPMS RNA binding protein with multiple splicing
RGS12 regulator of G-protein signaling 12
SCG2 secretogranin II
SCIN scinderin
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
SORBS3 sorbin and SH3 domain containing 3
STAB2 stabilin 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TFR2 transferrin receptor 2
TICAM1 toll-like receptor adaptor molecule 1
TMEM63A transmembrane protein 63A
TPMT thiopurine S-methyltransferase
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZNF235 zinc finger protein 235
ZNF324 zinc finger protein 324
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACADSB acyl-CoA dehydrogenase, short/branched chain
AEN apoptosis enhancing nuclease
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AMT aminomethyltransferase
ARG1 arginase 1
ARRB1 arrestin, beta 1
ATG10 autophagy related 10
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BEND5 BEN domain containing 5
CCDC6 coiled-coil domain containing 6
CD180 CD180 molecule
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCN6 chloride channel, voltage-sensitive 6
CLEC3B C-type lectin domain family 3, member B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CXCL2 chemokine (C-X-C motif) ligand 2
CXORF56 chromosome X open reading frame 56
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNMBP dynamin binding protein
DOLK dolichol kinase
DPY19L2P2 DPY19L2 pseudogene 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FRS2 fibroblast growth factor receptor substrate 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD3 frizzled class receptor 3
GAA glucosidase, alpha; acid
GEM GTP binding protein overexpressed in skeletal muscle
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRIP2 glutamate receptor interacting protein 2
GSTA4 glutathione S-transferase alpha 4
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H2AI histone cluster 1, H2ai
HIST1H3G histone cluster 1, H3g
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL11RA interleukin 11 receptor, alpha
IL2 interleukin 2
IL3RA interleukin 3 receptor, alpha (low affinity)
JUNB jun B proto-oncogene
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF13B kinesin family member 13B
KLHL26 kelch-like family member 26
LAMP5 lysosomal-associated membrane protein family, member 5
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LIN7B lin-7 homolog B (C. elegans)
LRRC6 leucine rich repeat containing 6
LTBP3 latent transforming growth factor beta binding protein 3
LTC4S leukotriene C4 synthase
MED31 mediator complex subunit 31
MKRN3 makorin ring finger protein 3
MMP9 matrix metallopeptidase 9
MRPL44 mitochondrial ribosomal protein L44
MTHFSD methenyltetrahydrofolate synthetase domain containing
MX1 MX dynamin-like GTPase 1
NCS1 neuronal calcium sensor 1
NDRG3 NDRG family member 3
NFE2L3 nuclear factor, erythroid 2-like 3
NOL10 nucleolar protein 10
NUBP2 nucleotide binding protein 2
NXPH4 neurexophilin 4
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
PMP22 peripheral myelin protein 22
POM121L2 POM121 transmembrane nucleoporin-like 2
PRMT7 protein arginine methyltransferase 7
PYGB phosphorylase, glycogen; brain
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RASAL1 RAS protein activator like 1 (GAP1 like)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SALL2 spalt-like transcription factor 2
SFT2D2 SFT2 domain containing 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMR3A submaxillary gland androgen regulated protein 3A
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX1A syntaxin 1A (brain)
TESK1 testis-specific kinase 1
THAP10 THAP domain containing 10
TIMP2 TIMP metallopeptidase inhibitor 2
TTC23 tetratricopeptide repeat domain 23
UBTD1 ubiquitin domain containing 1
ULK1 unc-51 like autophagy activating kinase 1
USB1 U6 snRNA biogenesis 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YOD1 YOD1 deubiquitinase
ZDHHC14 zinc finger, DHHC-type containing 14
ZIM2 zinc finger, imprinted 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF528 zinc finger protein 528
ZNF862 zinc finger protein 862