tiletamine-6516 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the tiletamine-6516 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ARC activity-regulated cytoskeleton-associated protein
ARTN artemin
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BDKRB1 bradykinin receptor B1
C11ORF80 chromosome 11 open reading frame 80
C14ORF105 chromosome 14 open reading frame 105
C19ORF66 chromosome 19 open reading frame 66
CALD1 caldesmon 1
CARD10 caspase recruitment domain family, member 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCKAR cholecystokinin A receptor
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDRT1 CMT1A duplicated region transcript 1
CFHR4 complement factor H-related 4
COL10A1 collagen, type X, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CSHL1 chorionic somatomammotropin hormone-like 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DESI2 desumoylating isopeptidase 2
EGR1 early growth response 1
EN1 engrailed homeobox 1
ETNK2 ethanolamine kinase 2
F5 coagulation factor V (proaccelerin, labile factor)
FRMD4B FERM domain containing 4B
FRMPD1 FERM and PDZ domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GPR35 G protein-coupled receptor 35
GSTA1 glutathione S-transferase alpha 1
GYPB glycophorin B (MNS blood group)
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HHAT hedgehog acyltransferase
HIST1H3B histone cluster 1, H3b
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HP1BP3 heterochromatin protein 1, binding protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1RN interleukin 1 receptor antagonist
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KLF12 Kruppel-like factor 12
KLF13 Kruppel-like factor 13
LAMB4 laminin, beta 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRRC23 leucine rich repeat containing 23
MIER2 mesoderm induction early response 1, family member 2
MYBPC3 myosin binding protein C, cardiac
NF1 neurofibromin 1
NIPAL3 NIPA-like domain containing 3
NR2C1 nuclear receptor subfamily 2, group C, member 1
OCA2 oculocutaneous albinism II
ONECUT1 one cut homeobox 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCL2 phospholipase C-like 2
PMP2 peripheral myelin protein 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PROL1 proline rich, lacrimal 1
PTAFR platelet-activating factor receptor
REC8 REC8 meiotic recombination protein
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGCC regulator of cell cycle
RGS12 regulator of G-protein signaling 12
RGS9 regulator of G-protein signaling 9
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL35A ribosomal protein L35a
RUNX1 runt-related transcription factor 1
SAMD9 sterile alpha motif domain containing 9
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2D1A SH2 domain containing 1A
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPN small nuclear ribonucleoprotein polypeptide N
SPAG8 sperm associated antigen 8
SPTBN5 spectrin, beta, non-erythrocytic 5
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STS steroid sulfatase (microsomal), isozyme S
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDRD12 tudor domain containing 12
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLN1 talin 1
TMEM212 transmembrane protein 212
TRAK1 trafficking protein, kinesin binding 1
TTLL1 tubulin tyrosine ligase-like family member 1
VARS valyl-tRNA synthetase
WNT6 wingless-type MMTV integration site family, member 6
XDH xanthine dehydrogenase
XYLB xylulokinase homolog (H. influenzae)
ZFAND5 zinc finger, AN1-type domain 5
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
ACTL8 actin-like 8
AMDHD2 amidohydrolase domain containing 2
ANP32A-IT1 ANP32A intronic transcript 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BBC3 BCL2 binding component 3
BCAS1 breast carcinoma amplified sequence 1
BTD biotinidase
C11ORF30 chromosome 11 open reading frame 30
C22ORF29 chromosome 22 open reading frame 29
C5AR2 complement component 5a receptor 2
CCDC186 coiled-coil domain containing 186
CCND3 cyclin D3
CCP110 centriolar coiled coil protein 110kDa
CD83 CD83 molecule
CDK20 cyclin-dependent kinase 20
CDR2L cerebellar degeneration-related protein 2-like
CHML choroideremia-like (Rab escort protein 2)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNN2 calponin 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
FAAH fatty acid amide hydrolase
FAM110B family with sequence similarity 110, member B
FAM131A family with sequence similarity 131, member A
FBRS fibrosin
FBXO22 F-box protein 22
FGGY FGGY carbohydrate kinase domain containing
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H4A histone cluster 1, H4a
HMOX1 heme oxygenase 1
IDI2-AS1 IDI2 antisense RNA 1
IMPAD1 inositol monophosphatase domain containing 1
IRS2 insulin receptor substrate 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0753 KIAA0753
KLHL21 kelch-like family member 21
KREMEN2 kringle containing transmembrane protein 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP2 low density lipoprotein receptor-related protein 2
LYRM9 LYR motif containing 9
LZTR1 leucine-zipper-like transcription regulator 1
MANBA mannosidase, beta A, lysosomal
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MECR mitochondrial trans-2-enoyl-CoA reductase
MITF microphthalmia-associated transcription factor
MRPL44 mitochondrial ribosomal protein L44
MTCL1 microtubule crosslinking factor 1
MYO1E myosin IE
NECAP2 NECAP endocytosis associated 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PADI1 peptidyl arginine deiminase, type I
PCDHB8 protocadherin beta 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGAP1 post-GPI attachment to proteins 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PODXL2 podocalyxin-like 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RBM23 RNA binding motif protein 23
RLN1 relaxin 1
RNF146 ring finger protein 146
RPL10L ribosomal protein L10-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAV1 salvador family WW domain containing protein 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC12A9 solute carrier family 12, member 9
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STX2 syntaxin 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TARP TCR gamma alternate reading frame protein
THBS3 thrombospondin 3
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPST1 tyrosylprotein sulfotransferase 1
TUBGCP5 tubulin, gamma complex associated protein 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR18 WD repeat domain 18
WNT10B wingless-type MMTV integration site family, member 10B
ZNF141 zinc finger protein 141
ZNF430 zinc finger protein 430
ZNF573 zinc finger protein 573
ZNF623 zinc finger protein 623