timolol-5645 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the timolol-5645 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ARNT aryl hydrocarbon receptor nuclear translocator
ATN1 atrophin 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BARX2 BARX homeobox 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1ORF54 chromosome 1 open reading frame 54
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CADM4 cell adhesion molecule 4
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL22 chemokine (C-C motif) ligand 22
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
COL13A1 collagen, type XIII, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CTAG2 cancer/testis antigen 2
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCTN1 dynactin 1
DMP1 dentin matrix acidic phosphoprotein 1
DOCK10 dedicator of cytokinesis 10
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFNB3 ephrin-B3
EPHA5 EPH receptor A5
EXOC7 exocyst complex component 7
EYA4 EYA transcriptional coactivator and phosphatase 4
FASLG Fas ligand (TNF superfamily, member 6)
FCMR Fc fragment of IgM receptor
FGF22 fibroblast growth factor 22
FPR2 formyl peptide receptor 2
FRZB frizzled-related protein
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GGT1 gamma-glutamyltransferase 1
GIMAP5 GTPase, IMAP family member 5
GLIPR1 GLI pathogenesis-related 1
GRIP2 glutamate receptor interacting protein 2
GRM7 glutamate receptor, metabotropic 7
GSK3A glycogen synthase kinase 3 alpha
HAND1 heart and neural crest derivatives expressed 1
HHLA1 HERV-H LTR-associating 1
ITGB8 integrin, beta 8
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIF25 kinesin family member 25
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLHL25 kelch-like family member 25
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KSR1 kinase suppressor of ras 1
LAMB4 laminin, beta 4
LATS1 large tumor suppressor kinase 1
MAOA monoamine oxidase A
MTCP1 mature T-cell proliferation 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOZ1 myozenin 1
NAG18 NAG18 mRNA
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PCDH12 protocadherin 12
PDAP1 PDGFA associated protein 1
PEG10 paternally expressed 10
PIAS2 protein inhibitor of activated STAT, 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PRPH2 peripherin 2 (retinal degeneration, slow)
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTAFR platelet-activating factor receptor
RFPL1S RFPL1 antisense RNA 1
RPS3A ribosomal protein S3A
SCARF1 scavenger receptor class F, member 1
SCRT1 scratch family zinc finger 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPAG6 sperm associated antigen 6
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRSF5 serine/arginine-rich splicing factor 5
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAPBP TAP binding protein (tapasin)
THRB thyroid hormone receptor, beta
TRIM15 tripartite motif containing 15
TRPM8 transient receptor potential cation channel, subfamily M, member 8
UBOX5 U-box domain containing 5
VWA5A von Willebrand factor A domain containing 5A
WDFY3 WD repeat and FYVE domain containing 3
WIPF1 WAS/WASL interacting protein family, member 1
WSCD1 WSC domain containing 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZNF280A zinc finger protein 280A
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
APOLD1 apolipoprotein L domain containing 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARR3 arrestin 3, retinal (X-arrestin)
BMP15 bone morphogenetic protein 15
C17ORF80 chromosome 17 open reading frame 80
CA11 carbonic anhydrase XI
CABP2 calcium binding protein 2
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CEP97 centrosomal protein 97kDa
CFAP45 cilia and flagella associated protein 45
CLGN calmegin
CLIC2 chloride intracellular channel 2
CLIP4 CAP-GLY domain containing linker protein family, member 4
CORT cortistatin
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CSTA cystatin A (stefin A)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DSPP dentin sialophosphoprotein
EDAR ectodysplasin A receptor
ELOVL4 ELOVL fatty acid elongase 4
EPN1 epsin 1
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
EXTL3 exostosin-like glycosyltransferase 3
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLJ22184
FRMD1 FERM domain containing 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GEMIN8 gem (nuclear organelle) associated protein 8
GFI1 growth factor independent 1 transcription repressor
GMPR guanosine monophosphate reductase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H1E histone cluster 1, H1e
HIST1H4E histone cluster 1, H4e
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HYAL3 hyaluronoglucosaminidase 3
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD17 potassium channel tetramerization domain containing 17
KIAA0319L KIAA0319-like
KLF7 Kruppel-like factor 7 (ubiquitous)
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KREMEN2 kringle containing transmembrane protein 2
LINC00597 long intergenic non-protein coding RNA 597
LONRF3 LON peptidase N-terminal domain and ring finger 3
LOXL3 lysyl oxidase-like 3
LPPR1 lipid phosphate phosphatase-related protein type 1
LRP5L low density lipoprotein receptor-related protein 5-like
MALL mal, T-cell differentiation protein-like
N4BP3 NEDD4 binding protein 3
NCALD neurocalcin delta
OGFRL1 opioid growth factor receptor-like 1
OVOL1 ovo-like zinc finger 1
OXCT2 3-oxoacid CoA transferase 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PODNL1 podocan-like 1
POLM polymerase (DNA directed), mu
PPT2 palmitoyl-protein thioesterase 2
PRF1 perforin 1 (pore forming protein)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIN2 Ras and Rab interactor 2
RNF2 ring finger protein 2
RNF43 ring finger protein 43
RPH3A rabphilin 3A
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RUNDC3B RUN domain containing 3B
S100A7 S100 calcium binding protein A7
SAG S-antigen; retina and pineal gland (arrestin)
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SDS serine dehydratase
SLC12A8 solute carrier family 12, member 8
SLC17A2 solute carrier family 17, member 2
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SSTR5 somatostatin receptor 5
STAB2 stabilin 2
TMEM19 transmembrane protein 19
VAV1 vav 1 guanine nucleotide exchange factor
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
YY2 YY2 transcription factor
ZNF134 zinc finger protein 134
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF37BP zinc finger protein 37B, pseudogene
ZNF551 zinc finger protein 551
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862