tinidazole-4370 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tinidazole-4370 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAM8 ADAM metallopeptidase domain 8
ADGRA2 adhesion G protein-coupled receptor A2
AGBL2 ATP/GTP binding protein-like 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AJAP1 adherens junctions associated protein 1
ANKRD55 ankyrin repeat domain 55
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOC1 apolipoprotein C-I
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BIN1 bridging integrator 1
BTN3A1 butyrophilin, subfamily 3, member A1
C3 complement component 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC71 coiled-coil domain containing 71
CCL21 chemokine (C-C motif) ligand 21
CD53 CD53 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDHR2 cadherin-related family member 2
CFP complement factor properdin
CLEC2D C-type lectin domain family 2, member D
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
FABP7 fatty acid binding protein 7, brain
FGF16 fibroblast growth factor 16
FHL1 four and a half LIM domains 1
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GIF gastric intrinsic factor (vitamin B synthesis)
GPM6B glycoprotein M6B
GPR35 G protein-coupled receptor 35
GRIP2 glutamate receptor interacting protein 2
HAB1 B1 for mucin
HIST1H3I histone cluster 1, H3i
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICOS inducible T-cell co-stimulator
IL23A interleukin 23, alpha subunit p19
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
IVL involucrin
JAM2 junctional adhesion molecule 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KEL Kell blood group, metallo-endopeptidase
KLK13 kallikrein-related peptidase 13
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT2 keratin 2, type II
KRT75 keratin 75, type II
LAT2 linker for activation of T cells family, member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAU2 MAU2 sister chromatid cohesion factor
MBD2 methyl-CpG binding domain protein 2
MPP1 membrane protein, palmitoylated 1, 55kDa
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOX3 NADPH oxidase 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP188 nucleoporin 188kDa
NUP88 nucleoporin 88kDa
OGG1 8-oxoguanine DNA glycosylase
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PQLC2 PQ loop repeat containing 2
PRKCI protein kinase C, iota
PVT1 Pvt1 oncogene (non-protein coding)
RAD52 RAD52 homolog (S. cerevisiae)
RASIP1 Ras interacting protein 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
ROR2 receptor tyrosine kinase-like orphan receptor 2
RORA RAR-related orphan receptor A
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SOX2 SRY (sex determining region Y)-box 2
SPON1 spondin 1, extracellular matrix protein
STAB2 stabilin 2
STAC SH3 and cysteine rich domain
STMN3 stathmin-like 3
STRN3 striatin, calmodulin binding protein 3
SULT4A1 sulfotransferase family 4A, member 1
SYT11 synaptotagmin XI
THSD4 thrombospondin, type I, domain containing 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM29 tripartite motif containing 29
TSPAN32 tetraspanin 32
TTN titin
VCL vinculin
VPRBP Vpr (HIV-1) binding protein
ZFP64 ZFP64 zinc finger protein
ZNF646 zinc finger protein 646
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ANXA2P3 annexin A2 pseudogene 3
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BCL9 B-cell CLL/lymphoma 9
BIRC7 baculoviral IAP repeat containing 7
BLNK B-cell linker
C11ORF63 chromosome 11 open reading frame 63
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBX2 chromobox homolog 2
CCDC69 coiled-coil domain containing 69
CCNO cyclin O
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CORO7 coronin 7
CORT cortistatin
CRIP1 cysteine-rich protein 1 (intestinal)
CUZD1 CUB and zona pellucida-like domains 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEPDC5 DEP domain containing 5
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1L2 deoxyribonuclease I-like 2
ERCC6 excision repair cross-complementation group 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FAM169A family with sequence similarity 169, member A
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAS2 growth arrest-specific 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR157 G protein-coupled receptor 157
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSTP1 glutathione S-transferase pi 1
GTPBP6 GTP binding protein 6 (putative)
HAMP hepcidin antimicrobial peptide
HIST1H1E histone cluster 1, H1e
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IGSF6 immunoglobulin superfamily, member 6
IRF1 interferon regulatory factor 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2C integral membrane protein 2C
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF11 Kruppel-like factor 11
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KREMEN2 kringle containing transmembrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LGALS9 lectin, galactoside-binding, soluble, 9
LINC00597 long intergenic non-protein coding RNA 597
LOC390998 ribosomal protein L10 pseudogene
LRRTM2 leucine rich repeat transmembrane neuronal 2
MEFV Mediterranean fever
METTL2B methyltransferase like 2B
MMP3 matrix metallopeptidase 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPFFR1 neuropeptide FF receptor 1
NT5E 5'-nucleotidase, ecto (CD73)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
PCDHB3 protocadherin beta 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PROCR protein C receptor, endothelial
PVRL3 poliovirus receptor-related 3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS19 regulator of G-protein signaling 19
RNF208 ring finger protein 208
RPAP1 RNA polymerase II associated protein 1
S100A7 S100 calcium binding protein A7
SLC12A8 solute carrier family 12, member 8
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMIM14 small integral membrane protein 14
SOX12 SRY (sex determining region Y)-box 12
TEFM transcription elongation factor, mitochondrial
TTF2 transcription termination factor, RNA polymerase II
TUBA4B tubulin, alpha 4b
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
VIM vimentin
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX4 zinc finger homeobox 4
ZNF250 zinc finger protein 250
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41
ZNF573 zinc finger protein 573
ZSWIM1 zinc finger, SWIM-type containing 1