tiotropium Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Similar Terms
Downloads & Tools

Genes

580 genes differentially expressed following the tiotropium small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 7.5597
TBXA2R thromboxane A2 receptor 6.97601
DIPK1A divergent protein kinase domain 1A 6.74399
CD40 CD40 molecule, TNF receptor superfamily member 5 5.99896
RUSF1 RUS family member 1 5.89065
NECAP1 NECAP endocytosis associated 1 5.7921
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.75503
GSTZ1 glutathione S-transferase zeta 1 5.63443
MTMR10 myotubularin related protein 10 5.61615
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 5.59116
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.40157
TMX2 thioredoxin-related transmembrane protein 2 5.31708
FAF2 Fas associated factor family member 2 5.27186
GGCX gamma-glutamyl carboxylase 5.27085
OXA1L oxidase (cytochrome c) assembly 1-like 5.19653
COBLL1 cordon-bleu WH2 repeat protein-like 1 5.1468
COPS7A COP9 signalosome subunit 7A 5.00085
KLF2 Kruppel-like factor 2 4.98477
FAIM2 Fas apoptotic inhibitory molecule 2 4.94179
PRC1 protein regulator of cytokinesis 1 4.89286
C11ORF21 chromosome 11 open reading frame 21 4.74169
ZNF669 zinc finger protein 669 4.73866
CCDC86 coiled-coil domain containing 86 4.70928
AK1 adenylate kinase 1 4.66043
OSBPL3 oxysterol binding protein-like 3 4.56141
KIF1A kinesin family member 1A 4.53261
PITX1 paired-like homeodomain 1 4.5307
IFT22 intraflagellar transport 22 4.51893
ADRB2 adrenoceptor beta 2, surface 4.47281
CKAP4 cytoskeleton-associated protein 4 4.43743
KRTAP1-3 keratin associated protein 1-3 4.40165
C1RL complement component 1, r subcomponent-like 4.38404
GPR135 G protein-coupled receptor 135 4.38294
TMED9 transmembrane emp24 protein transport domain containing 9 4.36936
EML2 echinoderm microtubule associated protein like 2 4.36786
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 4.34166
CDC37L1 cell division cycle 37-like 1 4.32272
DDB1 damage-specific DNA binding protein 1, 127kDa 4.32054
RGCC regulator of cell cycle 4.31071
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.29541
ASTN2 astrotactin 2 4.28961
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 4.28784
IL11 interleukin 11 4.23553
CCR3 chemokine (C-C motif) receptor 3 4.23047
TTC17 tetratricopeptide repeat domain 17 4.22199
NSD2 nuclear receptor binding SET domain protein 2 4.19405
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 4.17688
NFX1 nuclear transcription factor, X-box binding 1 4.15609
STOML1 stomatin (EPB72)-like 1 4.14592
MORC4 MORC family CW-type zinc finger 4 4.14581
KDM4D lysine (K)-specific demethylase 4D 4.12589
ARHGAP22 Rho GTPase activating protein 22 4.11605
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 4.0987
SCAPER S-phase cyclin A-associated protein in the ER 4.0942
CD83 CD83 molecule 4.09387
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 4.07496
TRAPPC12 trafficking protein particle complex 12 4.04248
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 4.0389
PPP1R15A protein phosphatase 1, regulatory subunit 15A 4.02917
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 4.00042
CLTB clathrin, light chain B 3.99448
DMRT1 doublesex and mab-3 related transcription factor 1 3.99424
RAB6B RAB6B, member RAS oncogene family 3.96544
PARP8 poly (ADP-ribose) polymerase family, member 8 3.96359
ELAVL2 ELAV like neuron-specific RNA binding protein 2 3.96263
QRICH1 glutamine-rich 1 3.93407
NRG2 neuregulin 2 3.93343
PRPF19 pre-mRNA processing factor 19 3.91476
ARF4 ADP-ribosylation factor 4 3.91118
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 3.90826
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 3.89206
PTGES prostaglandin E synthase 3.88853
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.88278
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 3.88225
PRPH2 peripherin 2 (retinal degeneration, slow) 3.8523
GYPE glycophorin E (MNS blood group) 3.83891
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 3.82428
TRPV1 transient receptor potential cation channel, subfamily V, member 1 3.8209
HMBS hydroxymethylbilane synthase 3.8155
PAPOLB poly(A) polymerase beta (testis specific) 3.80791
AKR1D1 aldo-keto reductase family 1, member D1 3.80724
ZNF460 zinc finger protein 460 3.80001
PRPF4 pre-mRNA processing factor 4 3.79254
ANXA10 annexin A10 3.78946
SLCO3A1 solute carrier organic anion transporter family, member 3A1 3.78492
TBX5 T-box 5 3.78164
MASP2 mannan-binding lectin serine peptidase 2 3.77115
ZNF44 zinc finger protein 44 3.75659
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.71645
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 3.70146
ZNF239 zinc finger protein 239 3.70102
TARBP1 TAR (HIV-1) RNA binding protein 1 3.69837
ZNF394 zinc finger protein 394 3.69096
IL1RN interleukin 1 receptor antagonist 3.68841
DHRS7B dehydrogenase/reductase (SDR family) member 7B 3.67912
DEGS1 delta(4)-desaturase, sphingolipid 1 3.67808
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 3.67616
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.66918
MAP7D3 MAP7 domain containing 3 3.66264
ACAA1 acetyl-CoA acyltransferase 1 3.66105
VPS33B vacuolar protein sorting 33 homolog B (yeast) 3.66056
NRAP nebulin-related anchoring protein 3.65943
PRR15L proline rich 15-like 3.65632
GFI1B growth factor independent 1B transcription repressor 3.64355
EIPR1 EARP complex and GARP complex interacting protein 1 3.64344
NAT10 N-acetyltransferase 10 (GCN5-related) 3.64191
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 3.63677
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 3.63051
ECHDC2 enoyl CoA hydratase domain containing 2 3.62571
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 3.62355
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.61274
PRPS1 phosphoribosyl pyrophosphate synthetase 1 3.59759
RAD23B RAD23 homolog B (S. cerevisiae) 3.58429
LRRC8E leucine rich repeat containing 8 family, member E 3.57282
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 3.57142
NSUN6 NOP2/Sun domain family, member 6 3.55748
BRCA1 breast cancer 1, early onset 3.5548
ZCWPW1 zinc finger, CW type with PWWP domain 1 3.55349
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 3.55232
GAS6 growth arrest-specific 6 3.55026
TMEM156 transmembrane protein 156 3.53885
ULK4 unc-51 like kinase 4 3.53647
TCL1A T-cell leukemia/lymphoma 1A 3.53275
LYST lysosomal trafficking regulator 3.53087
USP3 ubiquitin specific peptidase 3 3.52681
FOXJ2 forkhead box J2 3.52663
PAMR1 peptidase domain containing associated with muscle regeneration 1 3.52537
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 3.52515
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.51978
ADAM30 ADAM metallopeptidase domain 30 3.51346
ZNF331 zinc finger protein 331 3.50565
ISL1 ISL LIM homeobox 1 3.50545
ETV3 ets variant 3 3.50465
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 3.50431
DTX4 deltex 4, E3 ubiquitin ligase 3.49887
PRSS16 protease, serine, 16 (thymus) 3.49874
TMEM8B transmembrane protein 8B 3.49251
PRG4 proteoglycan 4 3.4901
SIRT4 sirtuin 4 3.48163
GLRX5 glutaredoxin 5 3.47911
ARSL arylsulfatase L 3.47818
NRXN2 neurexin 2 3.47409
WDR55 WD repeat domain 55 3.46166
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.46046
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.45866
AKAP6 A kinase (PRKA) anchor protein 6 3.45559
SCGB1D1 secretoglobin, family 1D, member 1 3.45319
CADPS Ca++-dependent secretion activator 3.45274
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.44312
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 3.43507
NLRP1 NLR family, pyrin domain containing 1 3.43419
TAPT1 transmembrane anterior posterior transformation 1 3.42878
FAM110B family with sequence similarity 110, member B 3.42493
FRMPD1 FERM and PDZ domain containing 1 3.42414
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.416
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 3.41196
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.40602
MYNN myoneurin 3.39475
TOX4 TOX high mobility group box family member 4 3.3938
PEX16 peroxisomal biogenesis factor 16 3.38687
MED13L mediator complex subunit 13-like 3.38654
STYXL1 serine/threonine/tyrosine interacting-like 1 3.38005
ORM1 orosomucoid 1 3.36915
OAZ3 ornithine decarboxylase antizyme 3 3.36781
GANAB glucosidase, alpha; neutral AB 3.36331
TMEM9B TMEM9 domain family, member B 3.35867
GIP gastric inhibitory polypeptide 3.35619
TBRG4 transforming growth factor beta regulator 4 3.35213
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.35123
WNT3 wingless-type MMTV integration site family, member 3 3.34857
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 3.34629
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 3.34617
THBD thrombomodulin 3.34527
PTP4A2 protein tyrosine phosphatase type IVA, member 2 3.33622
MST1 macrophage stimulating 1 3.33538
CYB561D2 cytochrome b561 family, member D2 3.33177
IL18R1 interleukin 18 receptor 1 3.32804
APOA1 apolipoprotein A-I 3.32551
FMO4 flavin containing monooxygenase 4 3.31896
PPIF peptidylprolyl isomerase F 3.31772
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 3.31586
FNDC3A fibronectin type III domain containing 3A 3.3158
STIM1 stromal interaction molecule 1 3.30093
PSD3 pleckstrin and Sec7 domain containing 3 3.29932
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 3.2982
CD5L CD5 molecule-like 3.28139
GPR12 G protein-coupled receptor 12 3.27739
SLC48A1 solute carrier family 48 (heme transporter), member 1 3.27465
PMS2P4 postmeiotic segregation increased 2 pseudogene 4 3.26965
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 3.26471
BTBD1 BTB (POZ) domain containing 1 3.26329
GPRC5C G protein-coupled receptor, class C, group 5, member C 3.25888
RDH16 retinol dehydrogenase 16 (all-trans) 3.25474
HIGD2A HIG1 hypoxia inducible domain family, member 2A 3.25258
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 3.25237
FOSL2 FOS-like antigen 2 3.2361
CCDC68 coiled-coil domain containing 68 3.23563
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 3.23549
SLC30A10 solute carrier family 30, member 10 3.23512
VGLL3 vestigial-like family member 3 3.23358
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.23347
R3HDM2 R3H domain containing 2 3.23042
ZNF668 zinc finger protein 668 3.22576
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 3.22301
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.22128
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.21906
EPYC epiphycan 3.21287
HLX H2.0-like homeobox 3.21107
MAPKBP1 mitogen-activated protein kinase binding protein 1 3.20984
KPTN kaptin (actin binding protein) 3.20892
ZNF204P zinc finger protein 204, pseudogene 3.20066
CNGB1 cyclic nucleotide gated channel beta 1 3.19952
NCSTN nicastrin 3.19762
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 3.19704
UBIAD1 UbiA prenyltransferase domain containing 1 3.19589
UST uronyl-2-sulfotransferase 3.19141
RCAN2 regulator of calcineurin 2 3.18994
TFB2M transcription factor B2, mitochondrial 3.18886
MAPT microtubule-associated protein tau 3.18247
CCL4 chemokine (C-C motif) ligand 4 3.16619
ADCY3 adenylate cyclase 3 3.15036
MAGEB1 melanoma antigen family B1 3.14907
RHOD ras homolog family member D 3.14546
CORIN corin, serine peptidase 3.14454
GINS4 GINS complex subunit 4 (Sld5 homolog) 3.14417
ZNF586 zinc finger protein 586 3.13959
PEX5L peroxisomal biogenesis factor 5-like 3.13889
PADI4 peptidyl arginine deiminase, type IV 3.13534
NAGA N-acetylgalactosaminidase, alpha- 3.13359
NIBAN1 niban apoptosis regulator 1 3.13053
TMED3 transmembrane emp24 protein transport domain containing 3 3.12992
TTC13 tetratricopeptide repeat domain 13 3.11209
NLRP2 NLR family, pyrin domain containing 2 3.11065
DDT D-dopachrome tautomerase 3.10547
ZPR1 ZPR1 zinc finger 3.09964
INTS5 integrator complex subunit 5 3.09143
TUBB2A tubulin, beta 2A class IIa 3.08952
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 3.0894
PHB2 prohibitin 2 3.08481
ZNF614 zinc finger protein 614 3.08212
SAR1A secretion associated, Ras related GTPase 1A 3.08205
LRRC75B leucine rich repeat containing 75B 3.07838
COX4I1 cytochrome c oxidase subunit IV isoform 1 3.07575
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 3.07303
MPZL2 myelin protein zero-like 2 3.07289
ENO3 enolase 3 (beta, muscle) 3.07279
BNC2 basonuclin 2 3.07139
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 3.0701
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 3.06938
HABP2 hyaluronan binding protein 2 3.06876
ISOC2 isochorismatase domain containing 2 3.0676
MGST3 microsomal glutathione S-transferase 3 3.06751
EVI5 ecotropic viral integration site 5 3.06316
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.06165
TMEM223 transmembrane protein 223 3.05631
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 3.04915
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 3.04725
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.04709
SHOX short stature homeobox 3.04458
GPR4 G protein-coupled receptor 4 3.04228
ODF1 outer dense fiber of sperm tails 1 3.04113
HRK harakiri, BCL2 interacting protein 3.03965
ACVR2A activin A receptor, type IIA 3.03759
USP24 ubiquitin specific peptidase 24 3.03659
FH fumarate hydratase 3.03653
METTL25B methyltransferase like 25B 3.03054
MAEA macrophage erythroblast attacher 3.02385
DHFR dihydrofolate reductase 3.0236
MOCOS molybdenum cofactor sulfurase 3.02276
LMBR1L limb development membrane protein 1-like 3.02167
ZNF136 zinc finger protein 136 3.01951
MAMLD1 mastermind-like domain containing 1 3.01896
OSR2 odd-skipped related transciption factor 2 3.01267
DISC1 disrupted in schizophrenia 1 3.00919
LRRC36 leucine rich repeat containing 36 3.0054
NUSAP1 nucleolar and spindle associated protein 1 3.00423
HHLA3 HERV-H LTR-associating 3 3.00338
PER3 period circadian clock 3 3.00191

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -12.5706
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.23597
NPY1R neuropeptide Y receptor Y1 -7.08172
EGF epidermal growth factor -7.03246
HMG20B high mobility group 20B -6.89791
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -6.84965
CYBC1 cytochrome b-245 chaperone 1 -6.84527
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -6.30012
IKZF1 IKAROS family zinc finger 1 (Ikaros) -5.93147
DYNLT3 dynein, light chain, Tctex-type 3 -5.90605
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) -5.64345
BPTF bromodomain PHD finger transcription factor -5.53727
AGR2 anterior gradient 2 -5.53179
NPY5R neuropeptide Y receptor Y5 -5.52148
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -5.41945
SIRT7 sirtuin 7 -5.33437
DPEP1 dipeptidase 1 (renal) -5.2822
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -5.1635
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -5.02859
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -5.02857
ZMPSTE24 zinc metallopeptidase STE24 -5.02748
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -5.02736
CTSA cathepsin A -4.98223
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.95403
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -4.89679
SIGLEC15 sialic acid binding Ig-like lectin 15 -4.84174
CRNKL1 crooked neck pre-mRNA splicing factor 1 -4.82118
ACAT2 acetyl-CoA acetyltransferase 2 -4.80878
TCN2 transcobalamin II -4.75527
SEC14L1 SEC14-like 1 (S. cerevisiae) -4.64028
REN renin -4.6393
CALB1 calbindin 1, 28kDa -4.6323
MFSD12 major facilitator superfamily domain containing 12 -4.62192
NQO2 NAD(P)H dehydrogenase, quinone 2 -4.58703
KL klotho -4.56723
CUBN cubilin (intrinsic factor-cobalamin receptor) -4.55552
VWF von Willebrand factor -4.54003
MED13 mediator complex subunit 13 -4.52173
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -4.51744
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -4.50166
SWAP70 SWAP switching B-cell complex 70kDa subunit -4.48262
UBE2I ubiquitin-conjugating enzyme E2I -4.46799
GASK1B golgi associated kinase 1B -4.43431
PCDHGB5 protocadherin gamma subfamily B, 5 -4.43309
PCDHB13 protocadherin beta 13 -4.41347
TFEC transcription factor EC -4.41327
MYO15B myosin XVB -4.38733
SCD stearoyl-CoA desaturase (delta-9-desaturase) -4.34081
ACAA2 acetyl-CoA acyltransferase 2 -4.29487
APOD apolipoprotein D -4.28388
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -4.27392
HRH3 histamine receptor H3 -4.26072
PLSCR3 phospholipid scramblase 3 -4.24255
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 -4.22874
ACOX1 acyl-CoA oxidase 1, palmitoyl -4.20033
UTP11 UTP11 small subunit processome component -4.19612
HP1BP3 heterochromatin protein 1, binding protein 3 -4.19534
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -4.19356
CRLF1 cytokine receptor-like factor 1 -4.18932
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -4.17314
PAOX polyamine oxidase (exo-N4-amino) -4.16829
PEPD peptidase D -4.14627
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -4.14341
ANKRD40 ankyrin repeat domain 40 -4.14203
CLCN7 chloride channel, voltage-sensitive 7 -4.12151
BRME1 break repair meiotic recombinase recruitment factor 1 -4.10885
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -4.10585
PPARA peroxisome proliferator-activated receptor alpha -4.0988
RIT1 Ras-like without CAAX 1 -4.08633
FXYD3 FXYD domain containing ion transport regulator 3 -4.08056
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -4.06002
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 -4.05662
ECE2 endothelin converting enzyme 2 -4.03163
CASP10 caspase 10, apoptosis-related cysteine peptidase -4.02543
BMP6 bone morphogenetic protein 6 -3.99212
AQP7 aquaporin 7 -3.98693
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -3.98247
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.98099
SP100 SP100 nuclear antigen -3.97467
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -3.97006
DIXDC1 DIX domain containing 1 -3.96224
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -3.9535
HLA-DMA major histocompatibility complex, class II, DM alpha -3.95112
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -3.93757
DDO D-aspartate oxidase -3.93594
NIPSNAP3B nipsnap homolog 3B (C. elegans) -3.92369
CCNP cyclin P -3.91374
ADM2 adrenomedullin 2 -3.90576
GNS glucosamine (N-acetyl)-6-sulfatase -3.90549
MFGE8 milk fat globule-EGF factor 8 protein -3.89743
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.88662
SP110 SP110 nuclear body protein -3.87486
PACC1 proton activated chloride channel 1 -3.86681
AKR1C3 aldo-keto reductase family 1, member C3 -3.86571
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -3.86507
PCNA proliferating cell nuclear antigen -3.81695
CHGB chromogranin B -3.81492
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -3.80737
TEK TEK tyrosine kinase, endothelial -3.80396
MRTFB myocardin related transcription factor B -3.79451
CLIC5 chloride intracellular channel 5 -3.79295
KRT20 keratin 20, type I -3.78511
DNM1L dynamin 1-like -3.77841
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.77607
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -3.77341
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.76705
LHX1 LIM homeobox 1 -3.76516
AMIGO2 adhesion molecule with Ig-like domain 2 -3.76494
FTSJ3 FtsJ homolog 3 (E. coli) -3.7415
TRIM48 tripartite motif containing 48 -3.74034
PCDHB6 protocadherin beta 6 -3.73829
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -3.73375
PCDHGA9 protocadherin gamma subfamily A, 9 -3.72999
JADE3 jade family PHD finger 3 -3.72151
PGM5 phosphoglucomutase 5 -3.71912
BLK BLK proto-oncogene, Src family tyrosine kinase -3.71236
UMOD uromodulin -3.69764
SUMO4 small ubiquitin-like modifier 4 -3.68082
KDM3A lysine (K)-specific demethylase 3A -3.67527
IPO8 importin 8 -3.66945
PCDHA9 protocadherin alpha 9 -3.66723
PCDHB3 protocadherin beta 3 -3.66655
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -3.66599
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -3.66458
ARFIP1 ADP-ribosylation factor interacting protein 1 -3.66113
RERGL RERG/RAS-like -3.65985
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -3.65769
SEPTIN2 septin 2 -3.65432
HLA-DMB major histocompatibility complex, class II, DM beta -3.64637
H3-3B H3.3 histone B -3.64551
LIG3 ligase III, DNA, ATP-dependent -3.64237
GSTCD glutathione S-transferase, C-terminal domain containing -3.63442
IRS1 insulin receptor substrate 1 -3.63435
PLPP2 phospholipid phosphatase 2 -3.62617
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -3.62548
BST2 bone marrow stromal cell antigen 2 -3.61692
TMEM131 transmembrane protein 131 -3.60585
GIPC2 GIPC PDZ domain containing family, member 2 -3.59879
GPATCH2L G patch domain containing 2-like -3.58057
ABHD6 abhydrolase domain containing 6 -3.57827
VEGFD vascular endothelial growth factor D -3.57729
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) -3.57275
FBP1 fructose-1,6-bisphosphatase 1 -3.5677
PDZD3 PDZ domain containing 3 -3.55949
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -3.5381
GVINP1 GTPase, very large interferon inducible pseudogene 1 -3.53803
DCC DCC netrin 1 receptor -3.53096
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -3.52852
IFNA6 interferon, alpha 6 -3.52646
MAU2 MAU2 sister chromatid cohesion factor -3.5183
CCKAR cholecystokinin A receptor -3.51321
SALL1 spalt-like transcription factor 1 -3.50556
MYH11 myosin, heavy chain 11, smooth muscle -3.50451
TRIM10 tripartite motif containing 10 -3.5002
DUS2 dihydrouridine synthase 2 -3.49873
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -3.49812
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.496
WHRN whirlin -3.49503
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -3.49425
TAS2R1 taste receptor, type 2, member 1 -3.48291
JAM2 junctional adhesion molecule 2 -3.47135
PPIEL peptidylprolyl isomerase E-like pseudogene -3.46963
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -3.46536
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -3.46345
LUC7L LUC7-like (S. cerevisiae) -3.46047
KANSL1L KAT8 regulatory NSL complex subunit 1-like -3.45863
TCF3 transcription factor 3 -3.45584
TMEM186 transmembrane protein 186 -3.4541
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -3.44463
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -3.43788
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -3.42751
DIDO1 death inducer-obliterator 1 -3.42086
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -3.42085
NPTX1 neuronal pentraxin I -3.41947
INVS inversin -3.41871
CLIP3 CAP-GLY domain containing linker protein 3 -3.40881
PARM1 prostate androgen-regulated mucin-like protein 1 -3.40518
RALBP1 ralA binding protein 1 -3.39491
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.39344
COL2A1 collagen, type II, alpha 1 -3.39182
IGFBP5 insulin-like growth factor binding protein 5 -3.39101
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -3.38662
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -3.38413
GFOD2 glucose-fructose oxidoreductase domain containing 2 -3.38071
USH1C Usher syndrome 1C (autosomal recessive, severe) -3.3692
PLCG1 phospholipase C, gamma 1 -3.36738
KIAA1614 KIAA1614 -3.36486
PQBP1 polyglutamine binding protein 1 -3.36278
LUC7L3 LUC7-like 3 (S. cerevisiae) -3.36212
AGPS alkylglycerone phosphate synthase -3.36039
GSDMD gasdermin D -3.3561
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 -3.35395
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -3.35221
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -3.34219
FSD1 fibronectin type III and SPRY domain containing 1 -3.32986
MCUB mitochondrial calcium uniporter dominant negative subunit beta -3.32703
PPP4R2 protein phosphatase 4, regulatory subunit 2 -3.31926
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -3.31555
PLA2R1 phospholipase A2 receptor 1, 180kDa -3.31463
LY86 lymphocyte antigen 86 -3.3116
WIF1 WNT inhibitory factor 1 -3.3056
HCLS1 hematopoietic cell-specific Lyn substrate 1 -3.30146
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -3.29948
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -3.29385
RGS13 regulator of G-protein signaling 13 -3.28868
BAHCC1 BAH domain and coiled-coil containing 1 -3.28136
CFAP70 cilia and flagella associated protein 70 -3.2779
TUBD1 tubulin, delta 1 -3.27403
BCL2L11 BCL2-like 11 (apoptosis facilitator) -3.27251
PDCD1 programmed cell death 1 -3.27152
CIDEA cell death-inducing DFFA-like effector a -3.27121
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -3.26781
QPCT glutaminyl-peptide cyclotransferase -3.2674
ELSPBP1 epididymal sperm binding protein 1 -3.26628
METTL9 methyltransferase like 9 -3.25338
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -3.25063
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -3.24998
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -3.24868
SP140 SP140 nuclear body protein -3.24863
FGF1 fibroblast growth factor 1 (acidic) -3.24591
HACD2 3-hydroxyacyl-CoA dehydratase 2 -3.24468
KHK ketohexokinase (fructokinase) -3.237
GPR6 G protein-coupled receptor 6 -3.2344
SH3GL1 SH3-domain GRB2-like 1 -3.23305
ETNK1 ethanolamine kinase 1 -3.22919
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -3.22755
CDK20 cyclin-dependent kinase 20 -3.22568
PCDH11X protocadherin 11 X-linked -3.22266
PRDM12 PR domain containing 12 -3.22068
JADE1 jade family PHD finger 1 -3.21159
THAP11 THAP domain containing 11 -3.2092
CASKIN2 CASK interacting protein 2 -3.20688
FAHD2A fumarylacetoacetate hydrolase domain containing 2A -3.2066
NRIP2 nuclear receptor interacting protein 2 -3.20518
FABP4 fatty acid binding protein 4, adipocyte -3.20003
NEURL1 neuralized E3 ubiquitin protein ligase 1 -3.19681
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -3.19655
AQP2 aquaporin 2 (collecting duct) -3.19521
HPS1 Hermansky-Pudlak syndrome 1 -3.19435
ADAM9 ADAM metallopeptidase domain 9 -3.19365
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -3.18516
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 -3.18453
CALCR calcitonin receptor -3.17662
ZFP36L2 ZFP36 ring finger protein-like 2 -3.17657
RECQL RecQ helicase-like -3.17614
TRIP12 thyroid hormone receptor interactor 12 -3.1738
SLC39A9 solute carrier family 39, member 9 -3.17147
RHOBTB1 Rho-related BTB domain containing 1 -3.16495
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -3.1645
CRTC1 CREB regulated transcription coactivator 1 -3.16228
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -3.16063
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -3.16056
TFF3 trefoil factor 3 (intestinal) -3.15235
SINHCAF SIN3-HDAC complex associated factor -3.14411
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -3.13825
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -3.13653
ARID4B AT rich interactive domain 4B (RBP1-like) -3.1352
TREML2 triggering receptor expressed on myeloid cells-like 2 -3.12393
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -3.12305
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma -3.11916
LINC01260 long intergenic non-protein coding RNA 1260 -3.11249
NASP nuclear autoantigenic sperm protein (histone-binding) -3.10741
DOK3 docking protein 3 -3.10394
RPS5 ribosomal protein S5 -3.10319
PCDHGA10 protocadherin gamma subfamily A, 10 -3.10182
HCG9 HLA complex group 9 (non-protein coding) -3.09643
KIF17 kinesin family member 17 -3.09641
ZFHX2 zinc finger homeobox 2 -3.092
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.09176
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -3.0832
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -3.08184
BACE2 beta-site APP-cleaving enzyme 2 -3.08129
TRIM38 tripartite motif containing 38 -3.08021
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -3.08002
U2SURP U2 snRNP-associated SURP domain containing -3.07614
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -3.06981
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -3.06808
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.06745
JAK3 Janus kinase 3 -3.06607
AOC3 amine oxidase, copper containing 3 -3.06448
ZSCAN16 zinc finger and SCAN domain containing 16 -3.06352
SH3GL3 SH3-domain GRB2-like 3 -3.062
CARMIL1 capping protein regulator and myosin 1 linker 1 -3.05498
LMOD1 leiomodin 1 (smooth muscle) -3.054
LUC7L2 LUC7-like 2 (S. cerevisiae) -3.05282
C7 complement component 7 -3.04972
LINC00574 long intergenic non-protein coding RNA 574 -3.04731
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -3.04675
MILR1 mast cell immunoglobulin-like receptor 1 -3.04452
SCGB1D2 secretoglobin, family 1D, member 2 -3.04188
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene) -3.04024
NOTCH4 notch 4 -3.03726
MACROH2A1 macroH2A.1 histone -3.03027
IL21 interleukin 21 -3.02979
NRTN neurturin -3.02655
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -3.02499
GRIK5 glutamate receptor, ionotropic, kainate 5 -3.02461
ZNRF4 zinc and ring finger 4 -3.01907
FGF3 fibroblast growth factor 3 -3.01632
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) -3.00507
ETV4 ets variant 4 -3.00481
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -3.00235